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- W2007575182 abstract "Cell-to-cell communications in bacteria mediated by small diffusible molecules termed as autoinducers (AI) are known to influence gene expression and pathogenicity. Oligopeptides and N-acylhomoserine lactones (AHL) are major AI molecules involved in intra-specific communication in Gram-positive and Gram-negative bacteria respectively, whereas boronated-diester molecules (AI-2) are involved in inter-specific communication among both Gram-positive and Gram-negative bacteria. Naturally occurring furocoumarins from grapefruit showed > 95% inhibition of AI-1 and AI-2 activities based on the Vibrio harveyi based autoinducer bioassay. Grapefruit juice and furocoumarins also inhibited biofilm formation by Escherichia coli O157:H7, Salmonella typhimurium and Pseudomonas aeruginosa. These results suggest that grape fruit juice and furocoumarins could serve as a source to develop bacterial intervention strategies targeting microbial cell signaling processes." @default.
- W2007575182 created "2016-06-24" @default.
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- W2007575182 date "2008-07-01" @default.
- W2007575182 modified "2023-10-03" @default.
- W2007575182 title "Grapefruit juice and its furocoumarins inhibits autoinducer signaling and biofilm formation in bacteria" @default.
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- W2007575182 doi "https://doi.org/10.1016/j.ijfoodmicro.2008.03.028" @default.
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