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- W2007582777 abstract "<i>Background:</i> Respiratory disability induced by dust exposure in coal workers is assessed by pulmonary function tests and radiological evidence of pneumoconiosis. High-resolution computed tomography (HR-CT) improves the visibility of tissue changes, but the value of the findings for the clinical evaluation is controversial. <i>Objectives:</i> It was the aim of this study to evaluate the correlation between the International Labour Office (ILO) classification and the degree of emphysema in HR-CT with self-reported dyspnea and pulmonary function tests including diffusion capacity for CO (D<sub>L,CO</sub>). <i>Methods:</i> We investigated 87 coal miners (aged 67 ± 6 years), having worked underground for 26 ± 9 years, with pulmonary function tests and HR-CT. Univariate associations were tested with correlation coefficients, and multivariable analyses used a stepwise forward regression model. <i>Results:</i> No aspect of the ILO classification showed a univariate correlation with dyspnea or forced expiratory flow in 1 s (FEV<sub>1</sub>). Emphysema CT score was strongly associated with D<sub>L,CO</sub> (r<sub>s</sub> = –0.40; p < 0.001) and FEV<sub>1</sub>/maximal vital capacity (r = –0.38; p < 0.001) in univariate analysis, but not with the clinical grade of dyspnea (r = –0.14; p = 0.256). CT emphysema score but not ILO classification was associated with FEV<sub>1</sub> in multivariable analyses (r<sub>s</sub> = –0.37; p < 0.001). Dyspnea was best approximated by D<sub>L,CO</sub> (r = –0.312; p = 0.008). <i>Conclusion:</i> The clinical grade of breathlessness was best approximated by D<sub>L,CO</sub>. HR-CT showed a good association with expiratory flow limitation. ILO classification of the chest radiograph may be a marker of exposure but conveys little information about the degree of respiratory impairment." @default.
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- W2007582777 date "2005-12-08" @default.
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- W2007582777 title "Radiological Findings, Pulmonary Function and Dyspnea in Underground Coal Miners" @default.
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- W2007582777 doi "https://doi.org/10.1159/000090200" @default.
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