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• W2007584648 abstract "LC-1 (also known as DMAPT or dimethylamino-parthenolide), a prodrug of parthenolide, was tested for anti-proliferative activity against glioma. LC-1 was found to have low micromolar cytotoxic activity against three glioma cell lines and was also found to be brain penetrant in healthy mice (2.1-3.0 brain-to-plasma ratio). In a syngeneic GL261 murine glioma model, LC-1 slowed tumor growth kinetics and extended the survival time of tumor-bearing mice in comparison to the vehicle control. Consequently, LC-1 represents a promising lead compound for further development as a glioma therapy." @default.
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• W2007584648 date "2015-06-01" @default.
• W2007584648 modified "2023-10-18" @default.
• W2007584648 title "Parthenolide prodrug LC-1 slows growth of intracranial glioma" @default.
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• W2007584648 doi "https://doi.org/10.1016/j.bmcl.2015.04.058" @default.
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