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- W2007584802 abstract "Significance Aging is accompanied by disruptive alterations in large-scale brain systems, such as the default mode network (DMN) and the associated hippocampus (HC) subsystem, which support higher cognitive functions. However, the exact form of DMN–HC alterations and concomitant memory deficits is largely unknown. We identified age-related decrements in resting-state functional connectivity of the cortical DMN, whereas elevated connectivity between the bilateral HC was found along with attenuated HC–cortical connectivity. Critically, elevated HC at rest restricts the degree to which HC interacts with other brain regions during memory tasks, and thus results in memory deficits. This study provides empirical evidence of how the relationship between the DMN and HC breaks down in aging and how such alterations underlie deficient mnemonic processing." @default.
- W2007584802 created "2016-06-24" @default.
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- W2007584802 date "2014-11-24" @default.
- W2007584802 modified "2023-10-12" @default.
- W2007584802 title "Elevated hippocampal resting-state connectivity underlies deficient neurocognitive function in aging" @default.
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- W2007584802 doi "https://doi.org/10.1073/pnas.1410233111" @default.
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