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• W2007585217 abstract "Lung cancer is the leading cause of cancer death worldwide in part due to our inability to identify which smokers are at highest risk and the lack of effective tools to detect the disease at its earliest and potentially curable stage. Recent results from the National Lung Screening Trial have shown that annual screening of high-risk smokers with low-dose helical computed tomography of the chest can reduce lung cancer mortality. However, molecular biomarkers are needed to identify which current and former smokers would benefit most from annual computed tomography scan screening in order to reduce the costs and morbidity associated with this procedure. Additionally, there is an urgent clinical need to develop biomarkers that can distinguish benign from malignant lesions found on computed tomography of the chest given its very high false positive rate. This review highlights recent genetic, transcriptomic and epigenomic biomarkers that are emerging as tools for the early detection of lung cancer both in the diagnostic and screening setting." @default.
• W2007585217 created "2016-06-24" @default.
• W2007585217 creator A5012002845 @default.
• W2007585217 creator A5012357319 @default.
• W2007585217 creator A5025012859 @default.
• W2007585217 creator A5072296816 @default.
• W2007585217 creator A5082536523 @default.
• W2007585217 date "2013-07-19" @default.
• W2007585217 modified "2023-10-09" @default.
• W2007585217 title "Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era" @default.
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