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- W2007596663 abstract "The influence of estrin upon the development of spontaneous mammary gland carcinoma in susceptible mice is now well established. The explanation of the mechanism is still controversial, there being three theories: a), that estrin is absorbed by the mammary gland where it exerts a carcinogenic effect similar to that exerted by the carcinogenic hydrocarbons; b), that estrin merely causes hypertrophy of the mammary gland and in so doing increases the number of cancer-susceptible cells; c), that estrin has no immediate effect upon the mammary gland, its action being solely through stimulation of the pituitary to produce hormonal substances which incite mammary gland changes. In the current strin exper imentation (1, 2), the estrin has always been of exogenous origin, and it has appeared pertinent to the writers, for the following reasons, that the influence of estrin of endogenous origin should be studied, a), There is good reason to suppose that the estrins in the body are in a combined form, not as the free..." @default.
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- W2007596663 date "1938-09-01" @default.
- W2007596663 modified "2023-09-27" @default.
- W2007596663 title "ENDOCRINE FACTORS INFLUENCING TUMOR DEVELOPMENT1THE EFFECT OF PROLAN UPON THE MARSH-BUFFALO ADENOCARCINOMA" @default.
- W2007596663 doi "https://doi.org/10.1210/endo-23-3-327" @default.
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