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• W2007604850 abstract "Computational analysis of environmental DNA and RNA sequences from material extracted from seawater samples has revealed the presence of abundant bacterial noncoding RNAs that resemble large ribozymes in size and complexity. Of particular interest are two new-found RNAs, called GOLLD and HEARO, that are amongst the largest and most complex RNAs discovered to date. These findings suggest that there are many more RNAs with extraordinary size, structural complexity, or other exceptional characteristics, waiting to be discovered in waters, soils and other environments yet to be explored. Existing DNA sequence databases carry only a tiny fraction of the total amount of DNA sequence space from bacterial species. Bioinformatics searches of genomic DNA from bacteria commonly identify new noncoding RNAs (ncRNAs) such as riboswitches. Here, an updated computational pipeline is used to discover ncRNAs that rival the known large ribozymes in size and structural complexity; other such RNAs probably remain to be discovered. Estimates of the total number of bacterial species1,2,3 indicate that existing DNA sequence databases carry only a tiny fraction of the total amount of DNA sequence space represented by this division of life. Indeed, environmental DNA samples have been shown to encode many previously unknown classes of proteins4 and RNAs5. Bioinformatics searches6,7,8,9,10 of genomic DNA from bacteria commonly identify new noncoding RNAs (ncRNAs)10,11,12 such as riboswitches13,14. In rare instances, RNAs that exhibit more extensive sequence and structural conservation across a wide range of bacteria are encountered15,16. Given that large structured RNAs are known to carry out complex biochemical functions such as protein synthesis and RNA processing reactions, identifying more RNAs of great size and intricate structure is likely to reveal additional biochemical functions that can be achieved by RNA. We applied an updated computational pipeline17 to discover ncRNAs that rival the known large ribozymes in size and structural complexity or that are among the most abundant RNAs in bacteria that encode them. These RNAs would have been difficult or impossible to detect without examining environmental DNA sequences, indicating that numerous RNAs with extraordinary size, structural complexity, or other exceptional characteristics remain to be discovered in unexplored sequence space." @default.
• W2007604850 created "2016-06-24" @default.
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• W2007604850 date "2009-12-01" @default.
• W2007604850 modified "2023-10-16" @default.
• W2007604850 title "Exceptional structured noncoding RNAs revealed by bacterial metagenome analysis" @default.
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• W2007604850 doi "https://doi.org/10.1038/nature08586" @default.
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