Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007607304> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2007607304 abstract "Pancreatic lesions that are not clearly benign are often treated as malignant despite uncertainty in the true diagnosis due to the nearly universally fatal nature of pancreatic carcinoma (PC). Nuclear morphometry is a technique to quantify nuclear features too complex for the human eye to discern. We hypothesized that nuclear atypia can be quantified with morphometry in order to distinguish between chronic pancreatitis, IPMN, and PC. We retrospectively analyzed 14 specimens of chronic pancreatitis, 16 IPMN lesions, and 19 PC lesions. Clinicopathologic data were obtained. Nuclear morphometry determined overall atypia based on the average nuclear abnormality of 95 distinct nuclear features (a nuclear signature). For PC lesions, 5 nuclear features defined a classification score (CS) representing the proportion of aggressive nuclei in a given PC lesion. Statistical significance was determined with ANOVA and the Kruskal-Wallis test. The average age for all patients was 63 ± 15 years while 62% were male; there were no differences between the 3 groups. The follow up was approximately 4 years in all groups as well. The average nuclear atypia of chronic pancreatitis was 0.80, 0.99 for IPMN, and 1.08 for PC (P = 0.02). Importantly, based on 5 nuclear features, the CS for PC lesions that recurred was 87% while it was only 56% for those PC lesions that did recur (P = 0.04). The research describes a precise, accurate, and objective method to distinguish IPMN from PC. The CS and overall atypia score provides a method to not only objectively describe a given lesion, but it importantly describes where in the progression from benign to malignant lesion an unknown lesion exists. Clinically, this may be of great utility in risk stratifying unknown pancreatic lesions at the time of diagnosis or tissue biopsy. Citation Format: Evan S. Glazer, Kimberly A. Hill, Hao (Helen) Zhang, Peter Bartels, Joseph Watkins, David S. Alberts, Robert S. Krouse. Nuclear morphometry measures progressive atypia in the development of pancreatic carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1362. doi:10.1158/1538-7445.AM2014-1362" @default.
- W2007607304 created "2016-06-24" @default.
- W2007607304 creator A5000617102 @default.
- W2007607304 creator A5029541691 @default.
- W2007607304 creator A5042564531 @default.
- W2007607304 creator A5045022530 @default.
- W2007607304 creator A5049341927 @default.
- W2007607304 creator A5076190364 @default.
- W2007607304 creator A5088291412 @default.
- W2007607304 date "2014-09-30" @default.
- W2007607304 modified "2023-09-25" @default.
- W2007607304 title "Abstract 1362: Nuclear morphometry measures progressive atypia in the development of pancreatic carcinoma" @default.
- W2007607304 doi "https://doi.org/10.1158/1538-7445.am2014-1362" @default.
- W2007607304 hasPublicationYear "2014" @default.
- W2007607304 type Work @default.
- W2007607304 sameAs 2007607304 @default.
- W2007607304 citedByCount "0" @default.
- W2007607304 crossrefType "proceedings-article" @default.
- W2007607304 hasAuthorship W2007607304A5000617102 @default.
- W2007607304 hasAuthorship W2007607304A5029541691 @default.
- W2007607304 hasAuthorship W2007607304A5042564531 @default.
- W2007607304 hasAuthorship W2007607304A5045022530 @default.
- W2007607304 hasAuthorship W2007607304A5049341927 @default.
- W2007607304 hasAuthorship W2007607304A5076190364 @default.
- W2007607304 hasAuthorship W2007607304A5088291412 @default.
- W2007607304 hasConcept C118552586 @default.
- W2007607304 hasConcept C121608353 @default.
- W2007607304 hasConcept C126322002 @default.
- W2007607304 hasConcept C142724271 @default.
- W2007607304 hasConcept C204232928 @default.
- W2007607304 hasConcept C2775967933 @default.
- W2007607304 hasConcept C2777546739 @default.
- W2007607304 hasConcept C2780210213 @default.
- W2007607304 hasConcept C2781156865 @default.
- W2007607304 hasConcept C2781283455 @default.
- W2007607304 hasConcept C2781289014 @default.
- W2007607304 hasConcept C2989005 @default.
- W2007607304 hasConcept C3020076753 @default.
- W2007607304 hasConcept C50965678 @default.
- W2007607304 hasConcept C71924100 @default.
- W2007607304 hasConceptScore W2007607304C118552586 @default.
- W2007607304 hasConceptScore W2007607304C121608353 @default.
- W2007607304 hasConceptScore W2007607304C126322002 @default.
- W2007607304 hasConceptScore W2007607304C142724271 @default.
- W2007607304 hasConceptScore W2007607304C204232928 @default.
- W2007607304 hasConceptScore W2007607304C2775967933 @default.
- W2007607304 hasConceptScore W2007607304C2777546739 @default.
- W2007607304 hasConceptScore W2007607304C2780210213 @default.
- W2007607304 hasConceptScore W2007607304C2781156865 @default.
- W2007607304 hasConceptScore W2007607304C2781283455 @default.
- W2007607304 hasConceptScore W2007607304C2781289014 @default.
- W2007607304 hasConceptScore W2007607304C2989005 @default.
- W2007607304 hasConceptScore W2007607304C3020076753 @default.
- W2007607304 hasConceptScore W2007607304C50965678 @default.
- W2007607304 hasConceptScore W2007607304C71924100 @default.
- W2007607304 hasLocation W20076073041 @default.
- W2007607304 hasOpenAccess W2007607304 @default.
- W2007607304 hasPrimaryLocation W20076073041 @default.
- W2007607304 hasRelatedWork W1592307055 @default.
- W2007607304 hasRelatedWork W1936914174 @default.
- W2007607304 hasRelatedWork W1964560778 @default.
- W2007607304 hasRelatedWork W2001765783 @default.
- W2007607304 hasRelatedWork W2043474347 @default.
- W2007607304 hasRelatedWork W2073251443 @default.
- W2007607304 hasRelatedWork W2086432417 @default.
- W2007607304 hasRelatedWork W2087227224 @default.
- W2007607304 hasRelatedWork W2088464476 @default.
- W2007607304 hasRelatedWork W2094290949 @default.
- W2007607304 hasRelatedWork W2102447473 @default.
- W2007607304 hasRelatedWork W2155915237 @default.
- W2007607304 hasRelatedWork W2165478648 @default.
- W2007607304 hasRelatedWork W2312537442 @default.
- W2007607304 hasRelatedWork W2400625822 @default.
- W2007607304 hasRelatedWork W2401667154 @default.
- W2007607304 hasRelatedWork W2411038369 @default.
- W2007607304 hasRelatedWork W2414846683 @default.
- W2007607304 hasRelatedWork W2552766449 @default.
- W2007607304 hasRelatedWork W3119754472 @default.
- W2007607304 isParatext "false" @default.
- W2007607304 isRetracted "false" @default.
- W2007607304 magId "2007607304" @default.
- W2007607304 workType "article" @default.