FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007608533> ?p ?o ?g. }

• W2007608533 endingPage "271" @default.
• W2007608533 startingPage "262" @default.
• W2007608533 abstract "Nitroxyl (HNO/NO−) is a molecule which results from one-electron reduction of nitric oxide (NO). It is considered to be a pharmacologically important particle because of its cardiovascular effects and potential anticancer activity. Due to molecule instability studies on nitroxyl biological activity require the use of donor compounds. In the present study Angeli’s salt (Na2N2O3) was used as the nitroxyl donor and cytotoxicity of HNO/NO− against human lymphocytes and A549 and HT29 cancer cells was examined. The studies were performed under different pH conditions (pH 6.2 and 7.4) because it was suggested that formation of HNO and its toxicological effects may be stronger in tissues subjected to acidosis such as cancerous ones. It was shown that nitroxyl exerted cytotoxic effect against all three types of cells. Nitroxyl induced both apoptotic and necrotic cell death. The cytotoxic effect analyzed directly after cell treatment was stronger than that observed 24 h later. Differences in cell sensitivity to nitroxyl were observed – proliferating lymphocytes were the most sensitive cells. It was also shown that pro-oxidant activity of nitroxyl was stronger under slightly acidic conditions as compared to physiological pH but this difference was not always reflected in the observed cytotoxic effect, especially when the effect was measured 24 h after cell treatment. Thus, relatively high toxicity of nitroxyl against normal cells and its ability to induce not only apoptotic but also necrotic cell death make use of this molecule in cancer therapy questionable." @default.
• W2007608533 created "2016-06-24" @default.
• W2007608533 creator A5014108054 @default.
• W2007608533 creator A5041686448 @default.
• W2007608533 creator A5090986369 @default.
• W2007608533 date "2013-11-01" @default.
• W2007608533 modified "2023-10-14" @default.
• W2007608533 title "Cytotoxicity of nitroxyl (HNO/NO−) against normal and cancer human cells" @default.
• W2007608533 cites W1515031425 @default.
• W2007608533 cites W1541649582 @default.
• W2007608533 cites W1857559494 @default.
• W2007608533 cites W1964058023 @default.
• W2007608533 cites W1966607772 @default.
• W2007608533 cites W1966971174 @default.
• W2007608533 cites W1972624254 @default.
• W2007608533 cites W1977167080 @default.
• W2007608533 cites W1978100205 @default.
• W2007608533 cites W1983886923 @default.
• W2007608533 cites W1986183443 @default.
• W2007608533 cites W1987862298 @default.
• W2007608533 cites W1988666366 @default.
• W2007608533 cites W2001657345 @default.
• W2007608533 cites W2005205544 @default.
• W2007608533 cites W2006172842 @default.
• W2007608533 cites W2008757142 @default.
• W2007608533 cites W2010586937 @default.
• W2007608533 cites W2012810666 @default.
• W2007608533 cites W2015791471 @default.
• W2007608533 cites W2015979353 @default.
• W2007608533 cites W2026864649 @default.
• W2007608533 cites W2034334015 @default.
• W2007608533 cites W2034592170 @default.
• W2007608533 cites W2036551340 @default.
• W2007608533 cites W2036585283 @default.
• W2007608533 cites W2037053134 @default.
• W2007608533 cites W2041177052 @default.
• W2007608533 cites W2044113006 @default.
• W2007608533 cites W2045429393 @default.
• W2007608533 cites W2047279058 @default.
• W2007608533 cites W2048673047 @default.
• W2007608533 cites W2053686180 @default.
• W2007608533 cites W2062802606 @default.
• W2007608533 cites W2065281025 @default.
• W2007608533 cites W2077073945 @default.
• W2007608533 cites W2083354474 @default.
• W2007608533 cites W2091130738 @default.
• W2007608533 cites W2092145002 @default.
• W2007608533 cites W2095269702 @default.
• W2007608533 cites W2115080847 @default.
• W2007608533 cites W2126280238 @default.
• W2007608533 cites W2147004705 @default.
• W2007608533 cites W2157532432 @default.
• W2007608533 cites W2165332541 @default.
• W2007608533 cites W2169182236 @default.
• W2007608533 cites W2169232518 @default.
• W2007608533 cites W2182655233 @default.
• W2007608533 doi "https://doi.org/10.1016/j.cbi.2013.09.019" @default.
• W2007608533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24121186" @default.
• W2007608533 hasPublicationYear "2013" @default.
• W2007608533 type Work @default.
• W2007608533 sameAs 2007608533 @default.
• W2007608533 citedByCount "11" @default.
• W2007608533 countsByYear W20076085332014 @default.
• W2007608533 countsByYear W20076085332015 @default.
• W2007608533 countsByYear W20076085332016 @default.
• W2007608533 countsByYear W20076085332017 @default.
• W2007608533 countsByYear W20076085332019 @default.
• W2007608533 countsByYear W20076085332020 @default.
• W2007608533 countsByYear W20076085332021 @default.
• W2007608533 countsByYear W20076085332022 @default.
• W2007608533 crossrefType "journal-article" @default.
• W2007608533 hasAuthorship W2007608533A5014108054 @default.
• W2007608533 hasAuthorship W2007608533A5041686448 @default.
• W2007608533 hasAuthorship W2007608533A5090986369 @default.
• W2007608533 hasConcept C109316439 @default.
• W2007608533 hasConcept C121608353 @default.
• W2007608533 hasConcept C126322002 @default.
• W2007608533 hasConcept C1491633281 @default.
• W2007608533 hasConcept C154317977 @default.
• W2007608533 hasConcept C178790620 @default.
• W2007608533 hasConcept C185592680 @default.
• W2007608533 hasConcept C190283241 @default.
• W2007608533 hasConcept C202751555 @default.
• W2007608533 hasConcept C2776142628 @default.
• W2007608533 hasConcept C31573885 @default.
• W2007608533 hasConcept C519581460 @default.
• W2007608533 hasConcept C55493867 @default.
• W2007608533 hasConcept C71924100 @default.
• W2007608533 hasConcept C86803240 @default.
• W2007608533 hasConcept C96232424 @default.
• W2007608533 hasConcept C98274493 @default.
• W2007608533 hasConceptScore W2007608533C109316439 @default.
• W2007608533 hasConceptScore W2007608533C121608353 @default.
• W2007608533 hasConceptScore W2007608533C126322002 @default.
• W2007608533 hasConceptScore W2007608533C1491633281 @default.
• W2007608533 hasConceptScore W2007608533C154317977 @default.
• W2007608533 hasConceptScore W2007608533C178790620 @default.
• W2007608533 hasConceptScore W2007608533C185592680 @default.

• next