Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007608980> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2007608980 abstract "Microarray technology allows the measurement of expression levels of a large number of genes simultaneously. There are inherent biases in microarray data generated from an experiment. Various statistical methods have been proposed for data normalization and data analysis. This paper proposes a generalized additive model for the analysis of gene expression data. This model consists of two sub-models: a non-linear model and a linear model. We propose a two-step normalization algorithm to fit the two sub-models sequentially. The first step involves a non-parametric regression using lowess fits to adjust for non-linear systematic biases. The second step uses a linear ANOVA model to estimate the remaining effects including the interaction effect of genes and treatments, the effect of interest in a study. The proposed model is a generalization of the ANOVA model for microarray data analysis. We show correspondences between the lowess fit and the ANOVA model methods. The normalization procedure does not assume the majority of genes do not change their expression levels, and neither does it assume two channel intensities from the same spot are independent. The procedure can be applied to either one channel or two channel data from the experiments with multiple treatments or multiple nuisance factors. Two toxicogenomic experiment data sets and a simulated data set are used to contrast the proposed method with the commonly known lowess fit and ANOVA methods." @default.
- W2007608980 created "2016-06-24" @default.
- W2007608980 creator A5041574564 @default.
- W2007608980 creator A5049314583 @default.
- W2007608980 creator A5051461953 @default.
- W2007608980 date "2004-12-29" @default.
- W2007608980 modified "2023-09-27" @default.
- W2007608980 title "A Generalized Additive Model For Microarray Gene Expression Data Analysis" @default.
- W2007608980 cites W1570354362 @default.
- W2007608980 cites W1975971707 @default.
- W2007608980 cites W2002810210 @default.
- W2007608980 cites W2093017030 @default.
- W2007608980 cites W2100668965 @default.
- W2007608980 cites W2131097599 @default.
- W2007608980 cites W2158188865 @default.
- W2007608980 cites W2162169788 @default.
- W2007608980 cites W2170989872 @default.
- W2007608980 cites W2172240858 @default.
- W2007608980 cites W4253016408 @default.
- W2007608980 doi "https://doi.org/10.1081/bip-200025648" @default.
- W2007608980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15468752" @default.
- W2007608980 hasPublicationYear "2004" @default.
- W2007608980 type Work @default.
- W2007608980 sameAs 2007608980 @default.
- W2007608980 citedByCount "7" @default.
- W2007608980 countsByYear W20076089802018 @default.
- W2007608980 crossrefType "journal-article" @default.
- W2007608980 hasAuthorship W2007608980A5041574564 @default.
- W2007608980 hasAuthorship W2007608980A5049314583 @default.
- W2007608980 hasAuthorship W2007608980A5051461953 @default.
- W2007608980 hasConcept C104317684 @default.
- W2007608980 hasConcept C105795698 @default.
- W2007608980 hasConcept C114289077 @default.
- W2007608980 hasConcept C117251300 @default.
- W2007608980 hasConcept C124101348 @default.
- W2007608980 hasConcept C136886441 @default.
- W2007608980 hasConcept C144024400 @default.
- W2007608980 hasConcept C150194340 @default.
- W2007608980 hasConcept C16012445 @default.
- W2007608980 hasConcept C163175372 @default.
- W2007608980 hasConcept C19165224 @default.
- W2007608980 hasConcept C203223496 @default.
- W2007608980 hasConcept C24361400 @default.
- W2007608980 hasConcept C33923547 @default.
- W2007608980 hasConcept C41008148 @default.
- W2007608980 hasConcept C48921125 @default.
- W2007608980 hasConcept C54355233 @default.
- W2007608980 hasConcept C8415881 @default.
- W2007608980 hasConcept C86803240 @default.
- W2007608980 hasConcept C95371953 @default.
- W2007608980 hasConcept C99476002 @default.
- W2007608980 hasConceptScore W2007608980C104317684 @default.
- W2007608980 hasConceptScore W2007608980C105795698 @default.
- W2007608980 hasConceptScore W2007608980C114289077 @default.
- W2007608980 hasConceptScore W2007608980C117251300 @default.
- W2007608980 hasConceptScore W2007608980C124101348 @default.
- W2007608980 hasConceptScore W2007608980C136886441 @default.
- W2007608980 hasConceptScore W2007608980C144024400 @default.
- W2007608980 hasConceptScore W2007608980C150194340 @default.
- W2007608980 hasConceptScore W2007608980C16012445 @default.
- W2007608980 hasConceptScore W2007608980C163175372 @default.
- W2007608980 hasConceptScore W2007608980C19165224 @default.
- W2007608980 hasConceptScore W2007608980C203223496 @default.
- W2007608980 hasConceptScore W2007608980C24361400 @default.
- W2007608980 hasConceptScore W2007608980C33923547 @default.
- W2007608980 hasConceptScore W2007608980C41008148 @default.
- W2007608980 hasConceptScore W2007608980C48921125 @default.
- W2007608980 hasConceptScore W2007608980C54355233 @default.
- W2007608980 hasConceptScore W2007608980C8415881 @default.
- W2007608980 hasConceptScore W2007608980C86803240 @default.
- W2007608980 hasConceptScore W2007608980C95371953 @default.
- W2007608980 hasConceptScore W2007608980C99476002 @default.
- W2007608980 hasLocation W20076089801 @default.
- W2007608980 hasLocation W20076089802 @default.
- W2007608980 hasOpenAccess W2007608980 @default.
- W2007608980 hasPrimaryLocation W20076089801 @default.
- W2007608980 hasRelatedWork W1982208048 @default.
- W2007608980 hasRelatedWork W2007608980 @default.
- W2007608980 hasRelatedWork W2045301693 @default.
- W2007608980 hasRelatedWork W2124416866 @default.
- W2007608980 hasRelatedWork W2169910187 @default.
- W2007608980 hasRelatedWork W2562359147 @default.
- W2007608980 hasRelatedWork W2624501724 @default.
- W2007608980 hasRelatedWork W2738261032 @default.
- W2007608980 hasRelatedWork W4232833750 @default.
- W2007608980 hasRelatedWork W575332321 @default.
- W2007608980 isParatext "false" @default.
- W2007608980 isRetracted "false" @default.
- W2007608980 magId "2007608980" @default.
- W2007608980 workType "article" @default.