Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007611090> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2007611090 endingPage "961" @default.
- W2007611090 startingPage "959" @default.
- W2007611090 abstract "The therapeutic approach to recurrent well-differentiated thyroid cancer is based on the detection of active disease. While a measured increase of thyroglobulin level in an ablated patient is highly suggestive of recurrence, localization of the tumour is necessary for adequate treatment planning. A whole body scan with 131I yields false negative results in the presence of non-iodophyllic foci of disease. Hypermetabolic foci of differentiated thyroid carcinoma can be detected by gamma PET with 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG). This study retrospectively evaluated the therapeutic impact of the 18F-FDG scan in patients with suspected recurrent thyroid carcinoma in whom the iodine scan was negative. Twenty patients (five male, 15 female) aged 19-77 years, were suspected of having recurrent thyroid carcinoma due to elevated thyroglobulin levels and/or palpable neck findings. All whole body iodine scans obtained with diagnostic doses (74-148 MBq (2-4 mCi) of 131I), were reported normal, i.e., no iodophyllic foci were detected. Whole body gamma positron emission tomography (PET) imaging was performed in fasting patients following i.v. administration of 370 MBq (10 mCi) 18F-FDG, with a strict 1 h immobilization post-injection. Gamma PET results were validated either by anatomical imaging, repeat iodine scanning after administration of a therapeutic dose (at least 3,700 MBq (100 mCi) of 131I) or surgery. The impact of the FDG scan on patient management was evaluated by the referring physicians. Positive gamma PET results confirmed the presence of active disease in 14/15 patients. One false positive finding (fibrosis) and one false negative (carcinoid) were reported. Localization of hypermetabolic foci supported treatment decisions in 10 patients, and significantly altered therapeutic management in six others. Treatment was withheld in four patients with negative findings. The clinical impact of the scan in this patient group is similar to that reported in the literature and justifies its future implementation." @default.
- W2007611090 created "2016-06-24" @default.
- W2007611090 creator A5031383176 @default.
- W2007611090 creator A5057224158 @default.
- W2007611090 creator A5065305289 @default.
- W2007611090 creator A5076179064 @default.
- W2007611090 creator A5080058125 @default.
- W2007611090 creator A5080240981 @default.
- W2007611090 date "2003-09-01" @default.
- W2007611090 modified "2023-09-27" @default.
- W2007611090 title "The clinical impact of 18F-FDG gamma PET in patients with recurrent well differentiated thyroid carcinoma" @default.
- W2007611090 cites W1977401191 @default.
- W2007611090 cites W2012567249 @default.
- W2007611090 cites W2023286707 @default.
- W2007611090 cites W2061471040 @default.
- W2007611090 cites W2553456895 @default.
- W2007611090 doi "https://doi.org/10.1097/00006231-200309000-00003" @default.
- W2007611090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12960594" @default.
- W2007611090 hasPublicationYear "2003" @default.
- W2007611090 type Work @default.
- W2007611090 sameAs 2007611090 @default.
- W2007611090 citedByCount "19" @default.
- W2007611090 countsByYear W20076110902012 @default.
- W2007611090 countsByYear W20076110902015 @default.
- W2007611090 countsByYear W20076110902016 @default.
- W2007611090 countsByYear W20076110902020 @default.
- W2007611090 crossrefType "journal-article" @default.
- W2007611090 hasAuthorship W2007611090A5031383176 @default.
- W2007611090 hasAuthorship W2007611090A5057224158 @default.
- W2007611090 hasAuthorship W2007611090A5065305289 @default.
- W2007611090 hasAuthorship W2007611090A5076179064 @default.
- W2007611090 hasAuthorship W2007611090A5080058125 @default.
- W2007611090 hasAuthorship W2007611090A5080240981 @default.
- W2007611090 hasConcept C126322002 @default.
- W2007611090 hasConcept C126838900 @default.
- W2007611090 hasConcept C191897082 @default.
- W2007611090 hasConcept C192562407 @default.
- W2007611090 hasConcept C2775842073 @default.
- W2007611090 hasConcept C2777546739 @default.
- W2007611090 hasConcept C2778835679 @default.
- W2007611090 hasConcept C2779761222 @default.
- W2007611090 hasConcept C2989005 @default.
- W2007611090 hasConcept C2993294228 @default.
- W2007611090 hasConcept C526584372 @default.
- W2007611090 hasConcept C539932907 @default.
- W2007611090 hasConcept C71924100 @default.
- W2007611090 hasConceptScore W2007611090C126322002 @default.
- W2007611090 hasConceptScore W2007611090C126838900 @default.
- W2007611090 hasConceptScore W2007611090C191897082 @default.
- W2007611090 hasConceptScore W2007611090C192562407 @default.
- W2007611090 hasConceptScore W2007611090C2775842073 @default.
- W2007611090 hasConceptScore W2007611090C2777546739 @default.
- W2007611090 hasConceptScore W2007611090C2778835679 @default.
- W2007611090 hasConceptScore W2007611090C2779761222 @default.
- W2007611090 hasConceptScore W2007611090C2989005 @default.
- W2007611090 hasConceptScore W2007611090C2993294228 @default.
- W2007611090 hasConceptScore W2007611090C526584372 @default.
- W2007611090 hasConceptScore W2007611090C539932907 @default.
- W2007611090 hasConceptScore W2007611090C71924100 @default.
- W2007611090 hasIssue "9" @default.
- W2007611090 hasLocation W20076110901 @default.
- W2007611090 hasLocation W20076110902 @default.
- W2007611090 hasOpenAccess W2007611090 @default.
- W2007611090 hasPrimaryLocation W20076110901 @default.
- W2007611090 hasRelatedWork W1929014698 @default.
- W2007611090 hasRelatedWork W1983199845 @default.
- W2007611090 hasRelatedWork W2015146751 @default.
- W2007611090 hasRelatedWork W2034067364 @default.
- W2007611090 hasRelatedWork W2079915737 @default.
- W2007611090 hasRelatedWork W2084564460 @default.
- W2007611090 hasRelatedWork W2085144152 @default.
- W2007611090 hasRelatedWork W2418369749 @default.
- W2007611090 hasRelatedWork W77645468 @default.
- W2007611090 hasRelatedWork W2124952821 @default.
- W2007611090 hasVolume "24" @default.
- W2007611090 isParatext "false" @default.
- W2007611090 isRetracted "false" @default.
- W2007611090 magId "2007611090" @default.
- W2007611090 workType "article" @default.