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• W2007614114 abstract "A scalable and enantioselective synthesis of a potent S1P 1 agonist containing two stereogenic centers on a cyclopentane ring is described. Control of the absolute chirality of an amino alcohol precursor, generated via a robust phase-transfer catalyzed alkylation protocol, allows for substrate directed hydrogenation to install the second stereogenic center providing access to gram-quantities of compound 2 ." @default.
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• W2007614114 date "2009-07-01" @default.
• W2007614114 modified "2023-09-27" @default.
• W2007614114 title "A stereoselective and scalable synthesis of a conformationally constrained S1P1 agonist" @default.
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• W2007614114 doi "https://doi.org/10.1016/j.tetlet.2009.04.099" @default.
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