FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007618665> ?p ?o ?g. }

• W2007618665 endingPage "190" @default.
• W2007618665 startingPage "183" @default.
• W2007618665 abstract "In an electrophysiological study designed to examine the negative feedback effects of glucocorticoid hormones, we have recorded the electrical activity of 147 neurones in the paraventricular nucleus of the rat hypothalamus. 37 (25%) of the neurones were antidromically identified as projecting to the median eminence and were located at a mean depth of 2.35 ± 0.08 mm from the base of the brain, corresponding with the corticotropin-releasing factor-rich region of the nucleus. The mean firing rate of the identified cells was 4.7 ± 0.6 Hz which was not significantly different from that of adjacent, unidentified cells (5.6 ± 0.6 Hz). Most (1718, 94%) of these cells tested responded to painful somatosensory stimuli and 26 (74%) of the identified cells were inhibited by iontophoretic application of corticosterone and/or hydrocortisone, whereas only one cell was excited and 8 unaffected. Of the identified cells, only 18 (20%) were inhibited, 36 (41%) were excited and 34 (39%) were non-responsive. The proportion of inhibitory responses was thus greater for the identified cells (P < 0.005; χ2-test). For the identified cells, whose spontaneous activity was unaffected by glucocorticoid application, glutamate-evoked responses could usually be depressed by the application. The time course of all responses usually showed an immediate onset, increasing in magnitude and continuinng for extended periods following cessation of iontophoresis. Electrophysiologically identified magnocellular neurones were also tested and the majority (712, 58%) of vasopressin-secreting neurons were also found to be inhibited, whilst all (88, 100%) of the oxytocin-secreting neurones were excited by the glucocorticoid application. These results may represent an electrophysiological correlate of the negative feedback control of adrenocortical secretion and are discussed within this context." @default.
• W2007618665 created "2016-06-24" @default.
• W2007618665 creator A5051622981 @default.
• W2007618665 creator A5085727840 @default.
• W2007618665 date "1988-06-01" @default.
• W2007618665 modified "2023-10-10" @default.
• W2007618665 title "Iontophoretic application of glucocorticoids inhibits identified neurones in the rat paraventricular nucleus" @default.
• W2007618665 cites W1035983268 @default.
• W2007618665 cites W1964015085 @default.
• W2007618665 cites W1964767284 @default.
• W2007618665 cites W1965783991 @default.
• W2007618665 cites W1967477278 @default.
• W2007618665 cites W1967931773 @default.
• W2007618665 cites W1980828545 @default.
• W2007618665 cites W1993269415 @default.
• W2007618665 cites W2000645202 @default.
• W2007618665 cites W2001233532 @default.
• W2007618665 cites W2009064702 @default.
• W2007618665 cites W2015806134 @default.
• W2007618665 cites W2016008039 @default.
• W2007618665 cites W2016560944 @default.
• W2007618665 cites W2017946277 @default.
• W2007618665 cites W2027148563 @default.
• W2007618665 cites W2032462319 @default.
• W2007618665 cites W2032751475 @default.
• W2007618665 cites W2033336980 @default.
• W2007618665 cites W2036068946 @default.
• W2007618665 cites W2041736210 @default.
• W2007618665 cites W2056506502 @default.
• W2007618665 cites W2057776485 @default.
• W2007618665 cites W2067467155 @default.
• W2007618665 cites W2067901880 @default.
• W2007618665 cites W2068709061 @default.
• W2007618665 cites W2069784578 @default.
• W2007618665 cites W2082041220 @default.
• W2007618665 cites W2083178182 @default.
• W2007618665 cites W2084532301 @default.
• W2007618665 cites W2084576709 @default.
• W2007618665 cites W2095127814 @default.
• W2007618665 cites W2129340317 @default.
• W2007618665 doi "https://doi.org/10.1016/0006-8993(88)90157-6" @default.
• W2007618665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3401757" @default.
• W2007618665 hasPublicationYear "1988" @default.
• W2007618665 type Work @default.
• W2007618665 sameAs 2007618665 @default.
• W2007618665 citedByCount "71" @default.
• W2007618665 countsByYear W20076186652012 @default.
• W2007618665 countsByYear W20076186652013 @default.
• W2007618665 countsByYear W20076186652014 @default.
• W2007618665 countsByYear W20076186652015 @default.
• W2007618665 countsByYear W20076186652019 @default.
• W2007618665 countsByYear W20076186652020 @default.
• W2007618665 countsByYear W20076186652021 @default.
• W2007618665 countsByYear W20076186652022 @default.
• W2007618665 crossrefType "journal-article" @default.
• W2007618665 hasAuthorship W2007618665A5051622981 @default.
• W2007618665 hasAuthorship W2007618665A5085727840 @default.
• W2007618665 hasConcept C121731113 @default.
• W2007618665 hasConcept C126322002 @default.
• W2007618665 hasConcept C134018914 @default.
• W2007618665 hasConcept C169760540 @default.
• W2007618665 hasConcept C170493617 @default.
• W2007618665 hasConcept C17077164 @default.
• W2007618665 hasConcept C183529106 @default.
• W2007618665 hasConcept C185263204 @default.
• W2007618665 hasConcept C185592680 @default.
• W2007618665 hasConcept C2776176026 @default.
• W2007618665 hasConcept C2776370428 @default.
• W2007618665 hasConcept C2777003273 @default.
• W2007618665 hasConcept C2779067335 @default.
• W2007618665 hasConcept C2780352252 @default.
• W2007618665 hasConcept C2780723820 @default.
• W2007618665 hasConcept C2780841215 @default.
• W2007618665 hasConcept C29694410 @default.
• W2007618665 hasConcept C61174792 @default.
• W2007618665 hasConcept C71315377 @default.
• W2007618665 hasConcept C71924100 @default.
• W2007618665 hasConcept C86803240 @default.
• W2007618665 hasConceptScore W2007618665C121731113 @default.
• W2007618665 hasConceptScore W2007618665C126322002 @default.
• W2007618665 hasConceptScore W2007618665C134018914 @default.
• W2007618665 hasConceptScore W2007618665C169760540 @default.
• W2007618665 hasConceptScore W2007618665C170493617 @default.
• W2007618665 hasConceptScore W2007618665C17077164 @default.
• W2007618665 hasConceptScore W2007618665C183529106 @default.
• W2007618665 hasConceptScore W2007618665C185263204 @default.
• W2007618665 hasConceptScore W2007618665C185592680 @default.
• W2007618665 hasConceptScore W2007618665C2776176026 @default.
• W2007618665 hasConceptScore W2007618665C2776370428 @default.
• W2007618665 hasConceptScore W2007618665C2777003273 @default.
• W2007618665 hasConceptScore W2007618665C2779067335 @default.
• W2007618665 hasConceptScore W2007618665C2780352252 @default.
• W2007618665 hasConceptScore W2007618665C2780723820 @default.
• W2007618665 hasConceptScore W2007618665C2780841215 @default.
• W2007618665 hasConceptScore W2007618665C29694410 @default.
• W2007618665 hasConceptScore W2007618665C61174792 @default.
• W2007618665 hasConceptScore W2007618665C71315377 @default.
• W2007618665 hasConceptScore W2007618665C71924100 @default.

• next