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- W200761912 abstract "Initiation oftranscription fromthegenomeofaviansarcomavirusbyRNAdirected DNA polymerase invitro requires tRNA' asaprimer. ThetRNAis boundtotheviral genomebyasequence of16contiguous nucleotides (U-C-A-CG-U-C-G-G-G-G-U-C-A-C-Cp), beginning withthepenultimate baseatthe3' terminus oftheprimer andextending through theacceptor stemintoloop IVof thetRNA.Consequently, thenative conformation ofthetRNA mustbedisrupted bythebinding ofprimer totheviral genome. Thebinding sequence does notinclude twoadjacent residues ofpseudouridine inloop IV,whichdistinguish theprimer frommanyothertRNAs,andthe3'terminal adenosine ofprimer mayalsobeexcluded frombasepairing withtheviral genome." @default.
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- W200761912 date "1976-01-01" @default.
- W200761912 modified "2023-09-24" @default.
- W200761912 title "Nucleotide Sequence ThatBindsPrimerforDNA Synthesis totheAvianSarcoma VirusGenome" @default.
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