Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007624219> ?p ?o ?g. }
- W2007624219 endingPage "193" @default.
- W2007624219 startingPage "185" @default.
- W2007624219 abstract "Silymarin, which is extracted from the milk thistle (Silybum marianum), has been used for centuries for treating hepatic disorders and its hepatoprotective effects have been known for hundreds of years. Silymarin is a mixture of polyphenoic flavonoids, which include silibinin (silybin A and silybin B), isosilyin A and B, silychristin A and B, silydianin and other phenol compounds. The pharmacokinetics of silibinin shows fast absorption and elimination. Silymarin undergoes phase I and phase II metabolism, especially phase II conjugation reactions, it undergoes multiple conjugation reactions, and is primarily excreted into bile and urine. Silymarin has a good safety profile, but little is known regarding its potential for drug interaction. Silymarin has limited effect on the pharmacokinetics of several drugs in vivo; despite silymarin decreasing the activity of cytochrome P-450 (CYPs) enzymes, UDP-glucuronosyltransferase (UGT) enzyme, and reducing P-glycoprotein (P-gp) transport. Health-care practitioners should caution patients against co-administration of silymarin and pharmaceutical drugs." @default.
- W2007624219 created "2016-06-24" @default.
- W2007624219 creator A5007804443 @default.
- W2007624219 creator A5013341045 @default.
- W2007624219 creator A5065687527 @default.
- W2007624219 date "2009-01-01" @default.
- W2007624219 modified "2023-10-18" @default.
- W2007624219 title "Drug–drug interactions of silymarin on the perspective of pharmacokinetics" @default.
- W2007624219 cites W1487737439 @default.
- W2007624219 cites W1499850422 @default.
- W2007624219 cites W1532205533 @default.
- W2007624219 cites W1534042983 @default.
- W2007624219 cites W1748908920 @default.
- W2007624219 cites W1785872465 @default.
- W2007624219 cites W1963957404 @default.
- W2007624219 cites W1971041530 @default.
- W2007624219 cites W1972901261 @default.
- W2007624219 cites W1973062059 @default.
- W2007624219 cites W1975872727 @default.
- W2007624219 cites W1976498055 @default.
- W2007624219 cites W1979215811 @default.
- W2007624219 cites W1980297252 @default.
- W2007624219 cites W1981609637 @default.
- W2007624219 cites W1983080992 @default.
- W2007624219 cites W1983573880 @default.
- W2007624219 cites W1984173811 @default.
- W2007624219 cites W1984802375 @default.
- W2007624219 cites W1988223087 @default.
- W2007624219 cites W1989005300 @default.
- W2007624219 cites W1990598218 @default.
- W2007624219 cites W1996122715 @default.
- W2007624219 cites W1999481211 @default.
- W2007624219 cites W2001737389 @default.
- W2007624219 cites W2002884027 @default.
- W2007624219 cites W2003227142 @default.
- W2007624219 cites W2003808348 @default.
- W2007624219 cites W2009952114 @default.
- W2007624219 cites W2018752930 @default.
- W2007624219 cites W2020168919 @default.
- W2007624219 cites W2020245539 @default.
- W2007624219 cites W2020778508 @default.
- W2007624219 cites W2024587809 @default.
- W2007624219 cites W2024832107 @default.
- W2007624219 cites W2025663121 @default.
- W2007624219 cites W2026375486 @default.
- W2007624219 cites W2027131031 @default.
- W2007624219 cites W2037176332 @default.
- W2007624219 cites W2038261200 @default.
- W2007624219 cites W2043692942 @default.
- W2007624219 cites W2043703023 @default.
- W2007624219 cites W2045831232 @default.
- W2007624219 cites W2047062023 @default.
- W2007624219 cites W2047393168 @default.
- W2007624219 cites W2050049694 @default.
- W2007624219 cites W2052328885 @default.
- W2007624219 cites W2054992160 @default.
- W2007624219 cites W2057228175 @default.
- W2007624219 cites W2058928933 @default.
- W2007624219 cites W2060317640 @default.
- W2007624219 cites W2063528348 @default.
- W2007624219 cites W2064777755 @default.
- W2007624219 cites W2066504688 @default.
- W2007624219 cites W2067383107 @default.
- W2007624219 cites W2067644270 @default.
- W2007624219 cites W2070410120 @default.
- W2007624219 cites W2071092830 @default.
- W2007624219 cites W2073965718 @default.
- W2007624219 cites W2074514207 @default.
- W2007624219 cites W2076491064 @default.
- W2007624219 cites W2076708571 @default.
- W2007624219 cites W2078917293 @default.
- W2007624219 cites W2080835467 @default.
- W2007624219 cites W2082601604 @default.
- W2007624219 cites W2084450801 @default.
- W2007624219 cites W2085527615 @default.
- W2007624219 cites W2088392423 @default.
- W2007624219 cites W2090910729 @default.
- W2007624219 cites W2092204341 @default.
- W2007624219 cites W2104806386 @default.
- W2007624219 cites W2107473674 @default.
- W2007624219 cites W2108026241 @default.
- W2007624219 cites W2109028417 @default.
- W2007624219 cites W2110790042 @default.
- W2007624219 cites W2129658335 @default.
- W2007624219 cites W2131080175 @default.
- W2007624219 cites W2133531210 @default.
- W2007624219 cites W2133876246 @default.
- W2007624219 cites W2136564762 @default.
- W2007624219 cites W2139497313 @default.
- W2007624219 cites W2142154255 @default.
- W2007624219 cites W2144111899 @default.
- W2007624219 cites W2151680183 @default.
- W2007624219 cites W2152948824 @default.
- W2007624219 cites W2153712534 @default.
- W2007624219 cites W2154105843 @default.
- W2007624219 cites W2154766450 @default.
- W2007624219 cites W2157946922 @default.
- W2007624219 cites W2169214237 @default.