FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007624518> ?p ?o ?g. }

• W2007624518 endingPage "676" @default.
• W2007624518 startingPage "667" @default.
• W2007624518 abstract "Tissue engineering utilizing periodontal ligament stem cells (PDLSCs) has recently been proposed for the development of new periodontal regenerative therapies. Although the use of autologous PDLSC transplantation eliminates the potential of a significant host immune response against the donor cells, it is often difficult to generate enough PDLSCs from one donor source due to the variation of stem cell potential between donors and disease state of each patient. In this study, we examined the immunomodulatory properties of PDLSCs as candidates for new allogeneic stem cell-based therapies. Human PDLSCs displayed cell surface marker characteristics and differentiation potential similar to bone marrow stromal stem cells (BMSSCs) and dental pulp stem cells (DPSCs). PDLSCs, BMSSCs, and DPSCs inhibited peripheral blood mononuclear cell (PBMNC) proliferation stimulated with mitogen or in an allogeneic mixed lymphocyte reaction (MLR). Interestingly, gingival fibroblasts (GFs) also suppressed allogeneic PBMNC proliferation under both assay conditions. PDLSCs, BMSSCs, DPSCs, and GFs exhibited non-cell contact dependent suppression of PBMNC proliferation in co-cultures using transwells. Furthermore, conditioned media (CM) derived from each cell type pretreated with IFN-γ partially suppressed PBMNC proliferation when compared to CMs without IFN-γ stimulation. In all of these mesenchymal cell types cultured with activated PBMNCs, the expression of TGF-β1, hepatocyte growth factor (HGF) and indoleamine 2, 3-dioxygenase (IDO) was upregulated while IDO expression was upregulated following stimulation with IFN-γ. These results suggest that PDLSCs, BMSSCs, DPSCs, and GFs possess immunosuppressive properties mediated, in part, by soluble factors, produced by activated PBMNCs. J. Cell. Physiol. 219: 667–676, 2009. © 2009 Wiley-Liss, Inc." @default.
• W2007624518 created "2016-06-24" @default.
• W2007624518 creator A5011924224 @default.
• W2007624518 creator A5012947925 @default.
• W2007624518 creator A5062097448 @default.
• W2007624518 creator A5073460357 @default.
• W2007624518 creator A5087190367 @default.
• W2007624518 date "2009-06-01" @default.
• W2007624518 modified "2023-10-07" @default.
• W2007624518 title "Immunomodulatory properties of human periodontal ligament stem cells" @default.
• W2007624518 cites W1968442155 @default.
• W2007624518 cites W1969696192 @default.
• W2007624518 cites W1975087479 @default.
• W2007624518 cites W1981787940 @default.
• W2007624518 cites W1982408656 @default.
• W2007624518 cites W1993910454 @default.
• W2007624518 cites W2011653132 @default.
• W2007624518 cites W2012366026 @default.
• W2007624518 cites W2015260577 @default.
• W2007624518 cites W2016038850 @default.
• W2007624518 cites W2016695470 @default.
• W2007624518 cites W2020114480 @default.
• W2007624518 cites W2022430924 @default.
• W2007624518 cites W2026810826 @default.
• W2007624518 cites W2027012204 @default.
• W2007624518 cites W2028239901 @default.
• W2007624518 cites W2029399853 @default.
• W2007624518 cites W2033284503 @default.
• W2007624518 cites W2035976926 @default.
• W2007624518 cites W2039665103 @default.
• W2007624518 cites W2039742699 @default.
• W2007624518 cites W2039751388 @default.
• W2007624518 cites W2044113526 @default.
• W2007624518 cites W2044810442 @default.
• W2007624518 cites W2045699513 @default.
• W2007624518 cites W2047003816 @default.
• W2007624518 cites W2051789537 @default.
• W2007624518 cites W2056725513 @default.
• W2007624518 cites W2058834701 @default.
• W2007624518 cites W2058839233 @default.
• W2007624518 cites W2061981400 @default.
• W2007624518 cites W2064524784 @default.
• W2007624518 cites W2066273674 @default.
• W2007624518 cites W2071864824 @default.
• W2007624518 cites W2074624875 @default.
• W2007624518 cites W2074860865 @default.
• W2007624518 cites W2078344741 @default.
• W2007624518 cites W2087353148 @default.
• W2007624518 cites W2089663997 @default.
• W2007624518 cites W2091298885 @default.
• W2007624518 cites W2091526175 @default.
• W2007624518 cites W2091610929 @default.
• W2007624518 cites W2094796303 @default.
• W2007624518 cites W2095666785 @default.
• W2007624518 cites W2106117542 @default.
• W2007624518 cites W2110374090 @default.
• W2007624518 cites W2119939110 @default.
• W2007624518 cites W2122414869 @default.
• W2007624518 cites W2130516299 @default.
• W2007624518 cites W2132536379 @default.
• W2007624518 cites W2143237736 @default.
• W2007624518 cites W2144224215 @default.
• W2007624518 cites W2148562877 @default.
• W2007624518 cites W2150024150 @default.
• W2007624518 cites W2152857351 @default.
• W2007624518 cites W2157428877 @default.
• W2007624518 cites W2159341392 @default.
• W2007624518 cites W2159358845 @default.
• W2007624518 cites W2168639074 @default.
• W2007624518 cites W2170515238 @default.
• W2007624518 cites W2417524245 @default.
• W2007624518 cites W4210956735 @default.
• W2007624518 cites W4210991094 @default.
• W2007624518 cites W4247786673 @default.
• W2007624518 doi "https://doi.org/10.1002/jcp.21710" @default.
• W2007624518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19160415" @default.
• W2007624518 hasPublicationYear "2009" @default.
• W2007624518 type Work @default.
• W2007624518 sameAs 2007624518 @default.
• W2007624518 citedByCount "355" @default.
• W2007624518 countsByYear W20076245182012 @default.
• W2007624518 countsByYear W20076245182013 @default.
• W2007624518 countsByYear W20076245182014 @default.
• W2007624518 countsByYear W20076245182015 @default.
• W2007624518 countsByYear W20076245182016 @default.
• W2007624518 countsByYear W20076245182017 @default.
• W2007624518 countsByYear W20076245182018 @default.
• W2007624518 countsByYear W20076245182019 @default.
• W2007624518 countsByYear W20076245182020 @default.
• W2007624518 countsByYear W20076245182021 @default.
• W2007624518 countsByYear W20076245182022 @default.
• W2007624518 countsByYear W20076245182023 @default.
• W2007624518 crossrefType "journal-article" @default.
• W2007624518 hasAuthorship W2007624518A5011924224 @default.
• W2007624518 hasAuthorship W2007624518A5012947925 @default.
• W2007624518 hasAuthorship W2007624518A5062097448 @default.
• W2007624518 hasAuthorship W2007624518A5073460357 @default.
• W2007624518 hasAuthorship W2007624518A5087190367 @default.

• next