Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007639259> ?p ?o ?g. }
- W2007639259 abstract "To investigate the events involved in regulation of the secretogranin II (SgII) gene, luciferase reporter constructs were transfected into gonadotrope-derived, alphaT3-1 cells. DNA between -91 and -60 relative to the transcription start site was found to be required for GnRH induced SgII reporter gene activation. This region contains a consensus cAMP response element (CRE) and disruption of this CRE reduced GnRH responsiveness of the SgII promoter. CREB was shown to bind to the SgII CRE and transfection studies with a dominant-negative CREB mutant provided evidence that CREB is required for GnRH responsiveness of the SgII promoter. An expression vector for an inhibitor of the cAMP-dependent protein kinase was found to reduce the ability of cAMP or GnRH to activate the SgII-luciferase reporter gene. These studies offer evidence that GnRH-induced activation of the SgII promoter in the alphaT3-1 cell line requires cAMP-dependent protein kinase activity and a functional CRE within the 5'-flanking region of the gene." @default.
- W2007639259 created "2016-06-24" @default.
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- W2007639259 date "2003-01-01" @default.
- W2007639259 modified "2023-10-18" @default.
- W2007639259 title "Gonadotropin-releasing hormone-induced stimulation of the rat secretogranin II promoter involves activation of CREB" @default.
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- W2007639259 doi "https://doi.org/10.1016/s0303-7207(02)00334-9" @default.
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