FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007641004> ?p ?o ?g. }

• W2007641004 endingPage "8772" @default.
• W2007641004 startingPage "8764" @default.
• W2007641004 abstract "The surface protein internalin A (InlA) contributes to the invasion of human intestinal epithelial cells by Listeria monocytogenes. Screening of L. monocytogenes strains isolated from human clinical cases (n=46), foods (n=118), and healthy animals (n=58) in the United States revealed mutations in inlA leading to premature stop codons (PMSCs) in L. monocytogenes ribotypes DUP-1052A and DUP-16635A (PMSC mutation type 1), DUP-1025A and DUP-1031A (PMSC mutation type 2), and DUP-1046B and DUP-1062A (PMSC mutation type 3). While all DUP-1046B, DUP-1062A, DUP-16635A, and DUP-1031A isolates (n=76) contained inlA PMSCs, ribotypes DUP-1052A and DUP-1025A (n=72) contained isolates with and without inlA PMSCs. Western immunoblotting showed that all three inlA PMSCs result in the production of truncated and secreted InlA. Searches of the Pathogen Tracker database, which contains subtype and source information for more than 5,000 L. monocytogenes isolates, revealed that the six ribotypes shown to contain isolates with inlA PMSCs were overall more commonly isolated from foods than from human listeriosis cases. L. monocytogenes strains carrying inlA PMSCs also showed significantly (P=0.0004) reduced invasion of Caco-2 cells compared to isolates with homologous 3' inlA sequences without PMSCs. Invasion assays with an isogenic PMSC mutant further supported the observation that inlA PMSCs lead to reduced invasion of Caco-2 cells. Our data show that specific L. monocytogenes subtypes which are common among U.S. food isolates but rare among human listeriosis isolates carry inlA mutations that are associated with, and possibly at least partially responsible for, an attenuated invasion phenotype." @default.
• W2007641004 created "2016-06-24" @default.
• W2007641004 creator A5022305013 @default.
• W2007641004 creator A5060712325 @default.
• W2007641004 creator A5081537609 @default.
• W2007641004 creator A5082217142 @default.
• W2007641004 creator A5087036578 @default.
• W2007641004 date "2005-12-01" @default.
• W2007641004 modified "2023-10-17" @default.
• W2007641004 title "Select<i>Listeria monocytogenes</i>Subtypes Commonly Found in Foods Carry Distinct Nonsense Mutations in<i>inlA</i>, Leading to Expression of Truncated and Secreted Internalin A, and Are Associated with a Reduced Invasion Phenotype for Human Intestinal Epithelial Cells" @default.
• W2007641004 cites W1462775415 @default.
• W2007641004 cites W1532591676 @default.
• W2007641004 cites W1580898002 @default.
• W2007641004 cites W1899458988 @default.
• W2007641004 cites W1947263708 @default.
• W2007641004 cites W1969612992 @default.
• W2007641004 cites W1977141229 @default.
• W2007641004 cites W1996535143 @default.
• W2007641004 cites W2001553481 @default.
• W2007641004 cites W2021525641 @default.
• W2007641004 cites W205228075 @default.
• W2007641004 cites W2060913542 @default.
• W2007641004 cites W2076198022 @default.
• W2007641004 cites W2082928585 @default.
• W2007641004 cites W2087908626 @default.
• W2007641004 cites W2095655760 @default.
• W2007641004 cites W2098231290 @default.
• W2007641004 cites W2101793321 @default.
• W2007641004 cites W2102234847 @default.
• W2007641004 cites W2109448478 @default.
• W2007641004 cites W2115048893 @default.
• W2007641004 cites W2115896695 @default.
• W2007641004 cites W2116401204 @default.
• W2007641004 cites W2117776146 @default.
• W2007641004 cites W2121860020 @default.
• W2007641004 cites W2122842914 @default.
• W2007641004 cites W2124712142 @default.
• W2007641004 cites W2124874453 @default.
• W2007641004 cites W2125614837 @default.
• W2007641004 cites W2128569759 @default.
• W2007641004 cites W2133746705 @default.
• W2007641004 cites W2136913694 @default.
• W2007641004 cites W2154895476 @default.
• W2007641004 cites W2158721827 @default.
• W2007641004 cites W2161966014 @default.
• W2007641004 cites W2162243177 @default.
• W2007641004 cites W2236777032 @default.
• W2007641004 cites W4212861730 @default.
• W2007641004 doi "https://doi.org/10.1128/aem.71.12.8764-8772.2005" @default.
• W2007641004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1317312" @default.
• W2007641004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16332872" @default.
• W2007641004 hasPublicationYear "2005" @default.
• W2007641004 type Work @default.
• W2007641004 sameAs 2007641004 @default.
• W2007641004 citedByCount "166" @default.
• W2007641004 countsByYear W20076410042012 @default.
• W2007641004 countsByYear W20076410042013 @default.
• W2007641004 countsByYear W20076410042014 @default.
• W2007641004 countsByYear W20076410042015 @default.
• W2007641004 countsByYear W20076410042016 @default.
• W2007641004 countsByYear W20076410042017 @default.
• W2007641004 countsByYear W20076410042018 @default.
• W2007641004 countsByYear W20076410042019 @default.
• W2007641004 countsByYear W20076410042020 @default.
• W2007641004 countsByYear W20076410042021 @default.
• W2007641004 countsByYear W20076410042022 @default.
• W2007641004 countsByYear W20076410042023 @default.
• W2007641004 crossrefType "journal-article" @default.
• W2007641004 hasAuthorship W2007641004A5022305013 @default.
• W2007641004 hasAuthorship W2007641004A5060712325 @default.
• W2007641004 hasAuthorship W2007641004A5081537609 @default.
• W2007641004 hasAuthorship W2007641004A5082217142 @default.
• W2007641004 hasAuthorship W2007641004A5087036578 @default.
• W2007641004 hasBestOaLocation W20076410042 @default.
• W2007641004 hasConcept C104317684 @default.
• W2007641004 hasConcept C127716648 @default.
• W2007641004 hasConcept C2781350384 @default.
• W2007641004 hasConcept C48737797 @default.
• W2007641004 hasConcept C523546767 @default.
• W2007641004 hasConcept C54355233 @default.
• W2007641004 hasConcept C7602840 @default.
• W2007641004 hasConcept C86803240 @default.
• W2007641004 hasConcept C89423630 @default.
• W2007641004 hasConceptScore W2007641004C104317684 @default.
• W2007641004 hasConceptScore W2007641004C127716648 @default.
• W2007641004 hasConceptScore W2007641004C2781350384 @default.
• W2007641004 hasConceptScore W2007641004C48737797 @default.
• W2007641004 hasConceptScore W2007641004C523546767 @default.
• W2007641004 hasConceptScore W2007641004C54355233 @default.
• W2007641004 hasConceptScore W2007641004C7602840 @default.
• W2007641004 hasConceptScore W2007641004C86803240 @default.
• W2007641004 hasConceptScore W2007641004C89423630 @default.
• W2007641004 hasIssue "12" @default.
• W2007641004 hasLocation W20076410041 @default.
• W2007641004 hasLocation W20076410042 @default.
• W2007641004 hasLocation W20076410043 @default.
• W2007641004 hasLocation W20076410044 @default.
• W2007641004 hasLocation W20076410045 @default.

• next