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• W2007643457 abstract "GABAergic (γ-aminobutyric acid) transmission in the substantia nigra pars reticulata is critical for seizure control. We tested the hypothesis that there is a differential regional distribution and functionality of nigral GABAA receptor sites that is developmentally regulated. In adult rats, we determined the effects on flurothyl seizures of (Z)-3-[(aminoiminomethyl)thio]prop-2-enoic acid (ZAPA, a presumed agonist of the low-affinity GABAA receptor site), bicuculline (an antagonist of the low-affinity GABAA receptor site) and γ-vinyl-GABA (a GABA-transaminase inhibitor), infused bilaterally in anterior or posterior substantia nigra pars reticulata. ZAPA infusions (8 μg) were anticonvulsant in anterior substantia nigra but proconvulsant in posterior substantia nigra. Bicuculline infusions (100 ng) were proconvulsant in anterior substantia nigra but ineffective in posterior substantia nigra. An anticonvulsant dose of γ-vinyl-GABA, when infused in anterior substantia nigra, was proconvulsant when infused in posterior substantia nigra. In 15 day old rats, the effects of ZAPA were biphasic: 2 μg was anticonvulsant while 8 μg was proconvulsant. There was no regional specificity. The data suggest that with maturation there is functional regional segregation of specific GABAA receptor subtypes involved in substantia nigra-mediated seizure control." @default.
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• W2007643457 date "1996-08-01" @default.
• W2007643457 modified "2023-10-11" @default.
• W2007643457 title "Developmental regulation of regional functionality of substantia nigra GABAA receptors involved in seizures" @default.
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• W2007643457 doi "https://doi.org/10.1016/0014-2999(96)00341-x" @default.
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