Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007644443> ?p ?o ?g. }
- W2007644443 endingPage "504" @default.
- W2007644443 startingPage "489" @default.
- W2007644443 abstract "In this paper, we address the problem of discovering novel non-coding RNA (ncRNA) using primary sequence, and secondary structure conservation, focusing on ncRNA families with pseudoknotted structures. Our main technical result is an efficient algorithm for computing an optimum structural alignment of an RNA sequence against a genomic substring. This algorithm has two applications. First, by scanning a genome, we can identify novel (homologous) pseudoknotted ncRNA, and second, we can infer the secondary structure of the target aligned sequence. We test an implementation of our algorithm (PAL) and show that it has near-perfect behavior for predicting the structure of many known pseudoknots. Additionally, it can detect the true homologs with high sensitivity and specificity in controlled tests. We also use PAL to search entire viral genome and mouse genome for novel homologs of some viral and eukaryotic pseudoknots, respectively. In each case, we have found strong support for novel homologs." @default.
- W2007644443 created "2016-06-24" @default.
- W2007644443 creator A5028801735 @default.
- W2007644443 creator A5051872325 @default.
- W2007644443 creator A5073542996 @default.
- W2007644443 creator A5083185181 @default.
- W2007644443 date "2008-06-01" @default.
- W2007644443 modified "2023-09-25" @default.
- W2007644443 title "Structural Alignment of Pseudoknotted RNA" @default.
- W2007644443 cites W1513047926 @default.
- W2007644443 cites W1542426682 @default.
- W2007644443 cites W175036826 @default.
- W2007644443 cites W1950410402 @default.
- W2007644443 cites W1990549640 @default.
- W2007644443 cites W1995403172 @default.
- W2007644443 cites W1999410197 @default.
- W2007644443 cites W2004812096 @default.
- W2007644443 cites W2007550449 @default.
- W2007644443 cites W2008288996 @default.
- W2007644443 cites W2013195357 @default.
- W2007644443 cites W2037722828 @default.
- W2007644443 cites W2042881722 @default.
- W2007644443 cites W2061158331 @default.
- W2007644443 cites W2065225159 @default.
- W2007644443 cites W2073865971 @default.
- W2007644443 cites W2088938573 @default.
- W2007644443 cites W2104141342 @default.
- W2007644443 cites W2109297587 @default.
- W2007644443 cites W2120523244 @default.
- W2007644443 cites W2123241418 @default.
- W2007644443 cites W2130978693 @default.
- W2007644443 cites W2137677639 @default.
- W2007644443 cites W2138452362 @default.
- W2007644443 cites W2139993947 @default.
- W2007644443 cites W2155058605 @default.
- W2007644443 cites W2169751581 @default.
- W2007644443 doi "https://doi.org/10.1089/cmb.2007.0214" @default.
- W2007644443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18549303" @default.
- W2007644443 hasPublicationYear "2008" @default.
- W2007644443 type Work @default.
- W2007644443 sameAs 2007644443 @default.
- W2007644443 citedByCount "33" @default.
- W2007644443 countsByYear W20076444432012 @default.
- W2007644443 countsByYear W20076444432013 @default.
- W2007644443 countsByYear W20076444432014 @default.
- W2007644443 countsByYear W20076444432015 @default.
- W2007644443 countsByYear W20076444432016 @default.
- W2007644443 countsByYear W20076444432017 @default.
- W2007644443 countsByYear W20076444432018 @default.
- W2007644443 countsByYear W20076444432019 @default.
- W2007644443 countsByYear W20076444432020 @default.
- W2007644443 countsByYear W20076444432021 @default.
- W2007644443 countsByYear W20076444432022 @default.
- W2007644443 crossrefType "journal-article" @default.
- W2007644443 hasAuthorship W2007644443A5028801735 @default.
- W2007644443 hasAuthorship W2007644443A5051872325 @default.
- W2007644443 hasAuthorship W2007644443A5073542996 @default.
- W2007644443 hasAuthorship W2007644443A5083185181 @default.
- W2007644443 hasConcept C104317684 @default.
- W2007644443 hasConcept C126142528 @default.
- W2007644443 hasConcept C141231307 @default.
- W2007644443 hasConcept C162319229 @default.
- W2007644443 hasConcept C167625842 @default.
- W2007644443 hasConcept C182407805 @default.
- W2007644443 hasConcept C194993378 @default.
- W2007644443 hasConcept C199360897 @default.
- W2007644443 hasConcept C2778112365 @default.
- W2007644443 hasConcept C41008148 @default.
- W2007644443 hasConcept C45484198 @default.
- W2007644443 hasConcept C54355233 @default.
- W2007644443 hasConcept C64894306 @default.
- W2007644443 hasConcept C67705224 @default.
- W2007644443 hasConcept C70721500 @default.
- W2007644443 hasConcept C85468374 @default.
- W2007644443 hasConcept C86803240 @default.
- W2007644443 hasConcept C88031987 @default.
- W2007644443 hasConceptScore W2007644443C104317684 @default.
- W2007644443 hasConceptScore W2007644443C126142528 @default.
- W2007644443 hasConceptScore W2007644443C141231307 @default.
- W2007644443 hasConceptScore W2007644443C162319229 @default.
- W2007644443 hasConceptScore W2007644443C167625842 @default.
- W2007644443 hasConceptScore W2007644443C182407805 @default.
- W2007644443 hasConceptScore W2007644443C194993378 @default.
- W2007644443 hasConceptScore W2007644443C199360897 @default.
- W2007644443 hasConceptScore W2007644443C2778112365 @default.
- W2007644443 hasConceptScore W2007644443C41008148 @default.
- W2007644443 hasConceptScore W2007644443C45484198 @default.
- W2007644443 hasConceptScore W2007644443C54355233 @default.
- W2007644443 hasConceptScore W2007644443C64894306 @default.
- W2007644443 hasConceptScore W2007644443C67705224 @default.
- W2007644443 hasConceptScore W2007644443C70721500 @default.
- W2007644443 hasConceptScore W2007644443C85468374 @default.
- W2007644443 hasConceptScore W2007644443C86803240 @default.
- W2007644443 hasConceptScore W2007644443C88031987 @default.
- W2007644443 hasIssue "5" @default.
- W2007644443 hasLocation W20076444431 @default.
- W2007644443 hasLocation W20076444432 @default.
- W2007644443 hasOpenAccess W2007644443 @default.