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- W2007644596 abstract "A wealth of evidence indicates a fundamental role for inflammation in the pathogenesis of cardiovascular disease (CVD), contributing to the development and progression of atherosclerotic lesion formation, plaque rupture, and thrombosis. An increasing body of evidence supports a functional role for complement activation in the pathogenesis of CVD through pleiotropic effects on endothelial and haematopoietic cell function and haemostasis. Prospective and case control studies have reported strong relationships between several complement components and cardiovascular outcomes, and in vitro studies and animal models support a functional effect. Complement activation, in particular, generation of C5a and C5b-9, influences many processes involved in the development and progression of atherosclerosis, including promotion of endothelial cell activation, leukocyte infiltration into the extracellular matrix, stimulation of cytokine release from vascular smooth muscle cells, and promotion of plaque rupture. Complement activation also influences thrombosis, involving components of the mannose-binding lectin pathway, and C5b-9 in particular, through activation of platelets, promotion of fibrin formation, and impairment of fibrinolysis. The participation of the complement system in inflammation and thrombosis is consistent with the physiological role of the complement system as a rapid effector system conferring protection following vessel injury. However, in the context of CVD, these same processes contribute to development of atherosclerosis, plaque rupture, and thrombosis." @default.
- W2007644596 created "2016-06-24" @default.
- W2007644596 creator A5039319154 @default.
- W2007644596 date "2012-01-01" @default.
- W2007644596 modified "2023-10-11" @default.
- W2007644596 title "Complement Activation: An Emerging Player in the Pathogenesis of Cardiovascular Disease" @default.
- W2007644596 cites W121687570 @default.
- W2007644596 cites W146872388 @default.
- W2007644596 cites W1493824599 @default.
- W2007644596 cites W1501653583 @default.
- W2007644596 cites W1516140460 @default.
- W2007644596 cites W1526824133 @default.
- W2007644596 cites W1541349172 @default.
- W2007644596 cites W1545877367 @default.
- W2007644596 cites W1547722704 @default.
- W2007644596 cites W1588757304 @default.
- W2007644596 cites W1590131239 @default.
- W2007644596 cites W1590398299 @default.
- W2007644596 cites W1606956077 @default.
- W2007644596 cites W1812416290 @default.
- W2007644596 cites W1849785625 @default.
- W2007644596 cites W1939603229 @default.
- W2007644596 cites W1963973203 @default.
- W2007644596 cites W1970811013 @default.
- W2007644596 cites W1972644731 @default.
- W2007644596 cites W1974987486 @default.
- W2007644596 cites W1975593747 @default.
- W2007644596 cites W1976764697 @default.
- W2007644596 cites W1976824777 @default.
- W2007644596 cites W1979008403 @default.
- W2007644596 cites W1980470187 @default.
- W2007644596 cites W1980493655 @default.
- W2007644596 cites W1980895202 @default.
- W2007644596 cites W1981585558 @default.
- W2007644596 cites W1984433766 @default.
- W2007644596 cites W1985261073 @default.
- W2007644596 cites W1987074209 @default.
- W2007644596 cites W1990525122 @default.
- W2007644596 cites W1992005236 @default.
- W2007644596 cites W1992363798 @default.
- W2007644596 cites W1992576448 @default.
- W2007644596 cites W1992868764 @default.
- W2007644596 cites W1993060519 @default.
- W2007644596 cites W1993580673 @default.
- W2007644596 cites W1996863870 @default.
- W2007644596 cites W1996868603 @default.
- W2007644596 cites W1999336423 @default.
- W2007644596 cites W1999899896 @default.
- W2007644596 cites W2000045462 @default.
- W2007644596 cites W2000314257 @default.
- W2007644596 cites W2000512590 @default.
- W2007644596 cites W2002815598 @default.
- W2007644596 cites W2005646886 @default.
- W2007644596 cites W2007717046 @default.
- W2007644596 cites W2010121557 @default.
- W2007644596 cites W2011498518 @default.
- W2007644596 cites W2012178618 @default.
- W2007644596 cites W2012936598 @default.
- W2007644596 cites W2013976776 @default.
- W2007644596 cites W2014117331 @default.
- W2007644596 cites W2014216780 @default.
- W2007644596 cites W2014889564 @default.
- W2007644596 cites W2024786751 @default.
- W2007644596 cites W2025462550 @default.
- W2007644596 cites W2026724360 @default.
- W2007644596 cites W2027986001 @default.
- W2007644596 cites W2030750609 @default.
- W2007644596 cites W2032055408 @default.
- W2007644596 cites W2036080352 @default.
- W2007644596 cites W2036209716 @default.
- W2007644596 cites W2037699290 @default.
- W2007644596 cites W2038416229 @default.
- W2007644596 cites W2039646348 @default.
- W2007644596 cites W2041448730 @default.
- W2007644596 cites W2042391364 @default.
- W2007644596 cites W2042425014 @default.
- W2007644596 cites W2043922211 @default.
- W2007644596 cites W2044204097 @default.
- W2007644596 cites W2044723660 @default.
- W2007644596 cites W2048005561 @default.
- W2007644596 cites W2050217807 @default.
- W2007644596 cites W2051885018 @default.
- W2007644596 cites W2053137788 @default.
- W2007644596 cites W2054804035 @default.
- W2007644596 cites W2055412588 @default.
- W2007644596 cites W2055877361 @default.
- W2007644596 cites W2056355507 @default.
- W2007644596 cites W2057682008 @default.
- W2007644596 cites W2059141220 @default.
- W2007644596 cites W2060414966 @default.
- W2007644596 cites W2061716605 @default.
- W2007644596 cites W2062987984 @default.
- W2007644596 cites W2064791519 @default.
- W2007644596 cites W2065908828 @default.
- W2007644596 cites W2066092834 @default.
- W2007644596 cites W2067742571 @default.
- W2007644596 cites W2069976366 @default.
- W2007644596 cites W2070225439 @default.