Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007647006> ?p ?o ?g. }
- W2007647006 endingPage "302" @default.
- W2007647006 startingPage "290" @default.
- W2007647006 abstract "Lesion-specific enzymes repair different forms of DNA damage, yet all lesions elicit the same checkpoint response. The common intermediate required to mount a checkpoint response is thought to be single-stranded DNA (ssDNA), coated by replication protein A (RPA) and containing a primer-template junction. To identify factors important for initiating the checkpoint response, we screened for genes that, when overexpressed, could amplify a checkpoint signal to a weak allele of chk1 in fission yeast. We identified Ast1, a novel member of the XPG-related family of endo/exonucleases. Ast1 promotes checkpoint activation caused by the absence of the other XPG-related nucleases, Exo1 and Rad2, the homologue of Fen1. Each nuclease is recruited to DSBs, and promotes the formation of ssDNA for checkpoint activation and recombinational repair. For Rad2 and Exo1, this is independent of their S-phase role in Okazaki fragment processing. This XPG-related pathway is distinct from MRN-dependent responses, and each enzyme is critical for damage resistance in MRN mutants. Thus, multiple nucleases collaborate to initiate DNA damage responses, highlighting the importance of these responses to cellular fitness." @default.
- W2007647006 created "2016-06-24" @default.
- W2007647006 creator A5013107841 @default.
- W2007647006 creator A5079168094 @default.
- W2007647006 date "2012-12-04" @default.
- W2007647006 modified "2023-09-27" @default.
- W2007647006 title "Initiation of DNA damage responses through XPG-related nucleases" @default.
- W2007647006 cites W1600623344 @default.
- W2007647006 cites W1851871403 @default.
- W2007647006 cites W1875299626 @default.
- W2007647006 cites W1966509436 @default.
- W2007647006 cites W1969431807 @default.
- W2007647006 cites W1975532840 @default.
- W2007647006 cites W1979385111 @default.
- W2007647006 cites W1979587131 @default.
- W2007647006 cites W1982253988 @default.
- W2007647006 cites W1992875057 @default.
- W2007647006 cites W1993026474 @default.
- W2007647006 cites W1994909028 @default.
- W2007647006 cites W1995275643 @default.
- W2007647006 cites W2003577370 @default.
- W2007647006 cites W2004008931 @default.
- W2007647006 cites W2017928245 @default.
- W2007647006 cites W2023860520 @default.
- W2007647006 cites W2024172421 @default.
- W2007647006 cites W2027867451 @default.
- W2007647006 cites W2029452303 @default.
- W2007647006 cites W2034033535 @default.
- W2007647006 cites W2037728125 @default.
- W2007647006 cites W2040392790 @default.
- W2007647006 cites W2042645637 @default.
- W2007647006 cites W2042772109 @default.
- W2007647006 cites W2044472248 @default.
- W2007647006 cites W2046535007 @default.
- W2007647006 cites W2052547134 @default.
- W2007647006 cites W2055206436 @default.
- W2007647006 cites W2058582467 @default.
- W2007647006 cites W2058963557 @default.
- W2007647006 cites W2064477710 @default.
- W2007647006 cites W2066730622 @default.
- W2007647006 cites W2081995373 @default.
- W2007647006 cites W2082570233 @default.
- W2007647006 cites W2083231946 @default.
- W2007647006 cites W2090929835 @default.
- W2007647006 cites W2092202372 @default.
- W2007647006 cites W2094020226 @default.
- W2007647006 cites W2094785950 @default.
- W2007647006 cites W2098094078 @default.
- W2007647006 cites W2102466315 @default.
- W2007647006 cites W2110555186 @default.
- W2007647006 cites W2112348939 @default.
- W2007647006 cites W2117929916 @default.
- W2007647006 cites W2119312192 @default.
- W2007647006 cites W2119460775 @default.
- W2007647006 cites W2120126307 @default.
- W2007647006 cites W2122078632 @default.
- W2007647006 cites W2123458244 @default.
- W2007647006 cites W2123955384 @default.
- W2007647006 cites W2124583038 @default.
- W2007647006 cites W2124876195 @default.
- W2007647006 cites W2126492332 @default.
- W2007647006 cites W2128322002 @default.
- W2007647006 cites W2129308592 @default.
- W2007647006 cites W2131571249 @default.
- W2007647006 cites W2131978108 @default.
- W2007647006 cites W2132803630 @default.
- W2007647006 cites W2133231925 @default.
- W2007647006 cites W2137544621 @default.
- W2007647006 cites W2142348153 @default.
- W2007647006 cites W2144095509 @default.
- W2007647006 cites W2149199049 @default.
- W2007647006 cites W2158491954 @default.
- W2007647006 cites W2163787826 @default.
- W2007647006 cites W2165529795 @default.
- W2007647006 cites W2169437718 @default.
- W2007647006 cites W2171041530 @default.
- W2007647006 cites W2171598906 @default.
- W2007647006 cites W2194986544 @default.
- W2007647006 cites W2888511473 @default.
- W2007647006 cites W54191497 @default.
- W2007647006 doi "https://doi.org/10.1038/emboj.2012.322" @default.
- W2007647006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3553381" @default.
- W2007647006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23211746" @default.
- W2007647006 hasPublicationYear "2012" @default.
- W2007647006 type Work @default.
- W2007647006 sameAs 2007647006 @default.
- W2007647006 citedByCount "8" @default.
- W2007647006 countsByYear W20076470062013 @default.
- W2007647006 countsByYear W20076470062015 @default.
- W2007647006 countsByYear W20076470062017 @default.
- W2007647006 countsByYear W20076470062019 @default.
- W2007647006 countsByYear W20076470062020 @default.
- W2007647006 countsByYear W20076470062021 @default.
- W2007647006 countsByYear W20076470062023 @default.
- W2007647006 crossrefType "journal-article" @default.
- W2007647006 hasAuthorship W2007647006A5013107841 @default.
- W2007647006 hasAuthorship W2007647006A5079168094 @default.
- W2007647006 hasBestOaLocation W20076470062 @default.