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- W2007654892 endingPage "250" @default.
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- W2007654892 abstract "DJ-1 is a cancer- and Parkinson's disease-associated protein that participates in different intracellular signaling pathways to protect cells from toxic stresses. DJ-1 expression, oxidation, localization, and phosphorylation are often altered in human tumors, and DJ-1 has been implicated in various aspects of transformation, including uncontrolled proliferation, invasion, metastasis, and resistance to chemotherapy and apoptosis. Despite the strong relationship between DJ-1 and cancer, which made it a particularly attractive therapeutic target for cancer treatment, the detailed mechanisms of how this oncogene coordinates altered signaling with cell survival remains elusive. In this commentary, we discuss the role of DJ-1 in transformation, highlight some of the significant aspects of and prospects for therapeutically targeting the DJ-1 signaling in cancer, and describe what the future may hold." @default.
- W2007654892 created "2016-06-24" @default.
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- W2007654892 creator A5048115276 @default.
- W2007654892 creator A5065297872 @default.
- W2007654892 creator A5075316702 @default.
- W2007654892 date "2015-02-01" @default.
- W2007654892 modified "2023-09-29" @default.
- W2007654892 title "DJ-1 as a human oncogene and potential therapeutic target" @default.
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