FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007657789> ?p ?o ?g. }

• W2007657789 endingPage "1242" @default.
• W2007657789 startingPage "1232" @default.
• W2007657789 abstract "The AML1/ETO and PML/RARalpha leukemia fusion proteins induce acute myeloid leukemia by acting as transcriptional repressors. They interact with corepressors, such as N-CoR and SMRT, that recruit a multiprotein complex containing histone deacetylases on crucial myeloid differentiation genes. This leads to gene repression contributing to generate a differentiation block. We expressed in leukemia cells containing PML/RARalpha and AML1/ETO N-CoR protein fragments derived from fusion protein/corepressor interaction surfaces. This blocks N-CoR/SMRT binding by these fusion proteins, and disrupts the repressor protein complex. In consequence, the expression of genes repressed by these fusion proteins increases and differentiation response to vitamin D3 and retinoic acid is restored in previously resistant cells. The alteration of PML/RARalpha-N-CoR/SMRT connections triggers proteasomal degradation of the fusion protein. The N-CoR fragments are biologically effective also when directly transduced by virtue of a protein transduction domain. Our data indicate that fusion protein activity is permanently required to maintain the leukemia phenotype and show the route to developing a novel therapeutic approach for leukemia, based on its molecular pathogenesis." @default.
• W2007657789 created "2016-06-24" @default.
• W2007657789 creator A5016625443 @default.
• W2007657789 creator A5020193909 @default.
• W2007657789 creator A5023617257 @default.
• W2007657789 creator A5025576419 @default.
• W2007657789 creator A5042419118 @default.
• W2007657789 creator A5044691691 @default.
• W2007657789 creator A5069912344 @default.
• W2007657789 creator A5075512296 @default.
• W2007657789 creator A5086145812 @default.
• W2007657789 date "2005-02-24" @default.
• W2007657789 modified "2023-10-15" @default.
• W2007657789 title "Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells" @default.
• W2007657789 cites W1486948598 @default.
• W2007657789 cites W1496672801 @default.
• W2007657789 cites W1516721790 @default.
• W2007657789 cites W1520661990 @default.
• W2007657789 cites W1550565578 @default.
• W2007657789 cites W1553544241 @default.
• W2007657789 cites W1589900156 @default.
• W2007657789 cites W1594364161 @default.
• W2007657789 cites W1603742465 @default.
• W2007657789 cites W1677605583 @default.
• W2007657789 cites W1749479308 @default.
• W2007657789 cites W1752169014 @default.
• W2007657789 cites W1909732837 @default.
• W2007657789 cites W1968479682 @default.
• W2007657789 cites W1973023394 @default.
• W2007657789 cites W1973962332 @default.
• W2007657789 cites W1979895333 @default.
• W2007657789 cites W1982342754 @default.
• W2007657789 cites W1983547790 @default.
• W2007657789 cites W1983719963 @default.
• W2007657789 cites W1985197859 @default.
• W2007657789 cites W1986045651 @default.
• W2007657789 cites W1989444478 @default.
• W2007657789 cites W1996949194 @default.
• W2007657789 cites W2012253608 @default.
• W2007657789 cites W2019291081 @default.
• W2007657789 cites W2039702376 @default.
• W2007657789 cites W2044365745 @default.
• W2007657789 cites W2050249118 @default.
• W2007657789 cites W2050743111 @default.
• W2007657789 cites W2060817283 @default.
• W2007657789 cites W2064056777 @default.
• W2007657789 cites W2066756232 @default.
• W2007657789 cites W2068876833 @default.
• W2007657789 cites W2085411183 @default.
• W2007657789 cites W2096008106 @default.
• W2007657789 cites W2096958727 @default.
• W2007657789 cites W2103728018 @default.
• W2007657789 cites W2103894337 @default.
• W2007657789 cites W2105668301 @default.
• W2007657789 cites W2107367651 @default.
• W2007657789 cites W2125668148 @default.
• W2007657789 cites W2135373289 @default.
• W2007657789 cites W2138492937 @default.
• W2007657789 cites W2139460080 @default.
• W2007657789 cites W2139829399 @default.
• W2007657789 cites W2147505659 @default.
• W2007657789 cites W2147567567 @default.
• W2007657789 cites W2149902033 @default.
• W2007657789 cites W2152961603 @default.
• W2007657789 cites W2156575042 @default.
• W2007657789 cites W2162589082 @default.
• W2007657789 cites W2169677043 @default.
• W2007657789 cites W2301621308 @default.
• W2007657789 cites W2343463909 @default.
• W2007657789 cites W39836022 @default.
• W2007657789 cites W4256485308 @default.
• W2007657789 cites W765620171 @default.
• W2007657789 doi "https://doi.org/10.1038/sj.emboj.7600593" @default.
• W2007657789 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/556397" @default.
• W2007657789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15729358" @default.
• W2007657789 hasPublicationYear "2005" @default.
• W2007657789 type Work @default.
• W2007657789 sameAs 2007657789 @default.
• W2007657789 citedByCount "39" @default.
• W2007657789 countsByYear W20076577892012 @default.
• W2007657789 countsByYear W20076577892013 @default.
• W2007657789 countsByYear W20076577892014 @default.
• W2007657789 countsByYear W20076577892015 @default.
• W2007657789 countsByYear W20076577892018 @default.
• W2007657789 countsByYear W20076577892019 @default.
• W2007657789 countsByYear W20076577892020 @default.
• W2007657789 countsByYear W20076577892022 @default.
• W2007657789 crossrefType "journal-article" @default.
• W2007657789 hasAuthorship W2007657789A5016625443 @default.
• W2007657789 hasAuthorship W2007657789A5020193909 @default.
• W2007657789 hasAuthorship W2007657789A5023617257 @default.
• W2007657789 hasAuthorship W2007657789A5025576419 @default.
• W2007657789 hasAuthorship W2007657789A5042419118 @default.
• W2007657789 hasAuthorship W2007657789A5044691691 @default.
• W2007657789 hasAuthorship W2007657789A5069912344 @default.
• W2007657789 hasAuthorship W2007657789A5075512296 @default.
• W2007657789 hasAuthorship W2007657789A5086145812 @default.
• W2007657789 hasBestOaLocation W20076577892 @default.

• next