Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007658911> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2007658911 endingPage "16" @default.
- W2007658911 startingPage "11" @default.
- W2007658911 abstract "In isolated cardiac sarcoplasmic reticulum (SR) vesicles, methyl methacrylate (2.5-100mM) directly inhibited initial rates of Ca2+ uptake as well as the maximal uptake. Inhibition of SR Ca2+ uptake by methyl methacrylate was concentration-dependent, and the highest concentration of methyl methacrylate (100mM) almost completely inhibited the SR Ca2+ uptake. EC(50) of methyl methacrylate in percent inhibition of SR Ca2+ uptake was 16.1, 31.9, and 53.4mM at pCa 7.0, 6.6, and 6.0, respectively. At low Ca2+ concentrations (0.1-1 microM), SR vesicles treated with 20mM methyl methacrylate showed the decreased Ca2+ uptake rates. However, further increase of Ca2+ concentration to pCa 5.5 abolished the inhibitory effect of methyl methacrylate on SR Ca2+ uptake, showing no difference between the control and the methyl methacrylate-treated SR vesicles. From these results we could conclude that methyl methacrylate exerts a direct inhibition of cardiac SR Ca2+ uptake. This mechanism, at least in part, might contribute to the profound hypotension induced by methyl methacrylate. Supplementation of calcium ion appears to reduce the methyl methacrylate-induced cardiovascular disturbances efficiently." @default.
- W2007658911 created "2016-06-24" @default.
- W2007658911 creator A5000379501 @default.
- W2007658911 creator A5006659812 @default.
- W2007658911 creator A5062727569 @default.
- W2007658911 date "2003-01-01" @default.
- W2007658911 modified "2023-09-23" @default.
- W2007658911 title "Effects of methyl methacrylate on Ca2+ uptake of cardiac sarcoplasmic reticulum" @default.
- W2007658911 cites W1572418927 @default.
- W2007658911 cites W1593219092 @default.
- W2007658911 cites W1775749144 @default.
- W2007658911 cites W1966491895 @default.
- W2007658911 cites W1969433796 @default.
- W2007658911 cites W1971120075 @default.
- W2007658911 cites W1972075646 @default.
- W2007658911 cites W1976685033 @default.
- W2007658911 cites W1979379178 @default.
- W2007658911 cites W1980596612 @default.
- W2007658911 cites W1997114199 @default.
- W2007658911 cites W2015801102 @default.
- W2007658911 cites W2020745082 @default.
- W2007658911 cites W2044686379 @default.
- W2007658911 cites W2064457605 @default.
- W2007658911 cites W2085839273 @default.
- W2007658911 cites W2431695208 @default.
- W2007658911 cites W947071345 @default.
- W2007658911 doi "https://doi.org/10.1016/s1043-6618(02)00256-6" @default.
- W2007658911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12526856" @default.
- W2007658911 hasPublicationYear "2003" @default.
- W2007658911 type Work @default.
- W2007658911 sameAs 2007658911 @default.
- W2007658911 citedByCount "4" @default.
- W2007658911 countsByYear W20076589112015 @default.
- W2007658911 crossrefType "journal-article" @default.
- W2007658911 hasAuthorship W2007658911A5000379501 @default.
- W2007658911 hasAuthorship W2007658911A5006659812 @default.
- W2007658911 hasAuthorship W2007658911A5062727569 @default.
- W2007658911 hasConcept C12554922 @default.
- W2007658911 hasConcept C130316041 @default.
- W2007658911 hasConcept C132050475 @default.
- W2007658911 hasConcept C13965031 @default.
- W2007658911 hasConcept C158617107 @default.
- W2007658911 hasConcept C178790620 @default.
- W2007658911 hasConcept C185592680 @default.
- W2007658911 hasConcept C2777935641 @default.
- W2007658911 hasConcept C2780718992 @default.
- W2007658911 hasConcept C41625074 @default.
- W2007658911 hasConcept C44228677 @default.
- W2007658911 hasConcept C519063684 @default.
- W2007658911 hasConcept C521977710 @default.
- W2007658911 hasConcept C55493867 @default.
- W2007658911 hasConcept C86803240 @default.
- W2007658911 hasConceptScore W2007658911C12554922 @default.
- W2007658911 hasConceptScore W2007658911C130316041 @default.
- W2007658911 hasConceptScore W2007658911C132050475 @default.
- W2007658911 hasConceptScore W2007658911C13965031 @default.
- W2007658911 hasConceptScore W2007658911C158617107 @default.
- W2007658911 hasConceptScore W2007658911C178790620 @default.
- W2007658911 hasConceptScore W2007658911C185592680 @default.
- W2007658911 hasConceptScore W2007658911C2777935641 @default.
- W2007658911 hasConceptScore W2007658911C2780718992 @default.
- W2007658911 hasConceptScore W2007658911C41625074 @default.
- W2007658911 hasConceptScore W2007658911C44228677 @default.
- W2007658911 hasConceptScore W2007658911C519063684 @default.
- W2007658911 hasConceptScore W2007658911C521977710 @default.
- W2007658911 hasConceptScore W2007658911C55493867 @default.
- W2007658911 hasConceptScore W2007658911C86803240 @default.
- W2007658911 hasIssue "1" @default.
- W2007658911 hasLocation W20076589111 @default.
- W2007658911 hasLocation W20076589112 @default.
- W2007658911 hasOpenAccess W2007658911 @default.
- W2007658911 hasPrimaryLocation W20076589111 @default.
- W2007658911 hasRelatedWork W1544048330 @default.
- W2007658911 hasRelatedWork W1550734808 @default.
- W2007658911 hasRelatedWork W1566002227 @default.
- W2007658911 hasRelatedWork W1985391996 @default.
- W2007658911 hasRelatedWork W2020345256 @default.
- W2007658911 hasRelatedWork W2062353778 @default.
- W2007658911 hasRelatedWork W2412710947 @default.
- W2007658911 hasRelatedWork W2513634880 @default.
- W2007658911 hasRelatedWork W4239292317 @default.
- W2007658911 hasRelatedWork W2078792694 @default.
- W2007658911 hasVolume "47" @default.
- W2007658911 isParatext "false" @default.
- W2007658911 isRetracted "false" @default.
- W2007658911 magId "2007658911" @default.
- W2007658911 workType "article" @default.