FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007660474> ?p ?o ?g. }

• W2007660474 endingPage "1543" @default.
• W2007660474 startingPage "1534" @default.
• W2007660474 abstract "Application of histone deacetylase inhibitors (HDACi) to cells epigenetically alters their chromatin structure and induces transcriptional and cellular reparative events. This study investigated the application of two HDACi, valproic acid (VPA) and trichostatin A (TSA) on the induction of repair-associated responses in primary dental pulp cell (DPC) cultures. Flow cytometry demonstrated that TSA (100 nM, 400 nM) significantly increased cell viability. Neither HDACi was cytotoxic, although cell growth analysis revealed significant anti-proliferative effects at higher concentrations for VPA (>0.5 mM) and TSA (>50 nM). While high-content-analysis demonstrated that HDACi did not significantly induce caspase-3 or p21 activity, p53-expression was increased by VPA (3 mM, 5 mM) at 48 h. HDACi-exposure induced mineralization per cell dose-dependently to a plateau level (VPA-0.125 mM and TSA-25 nM) with accompanying increases in mineralization/dentinogenic-associated gene expression at 5 days (DMP-1, BMP-2/-4, Nestin) and 10 days (DSPP, BMP-2/-4). Both HDACis, at a range of concentrations, significantly stimulated osteopontin and BMP-2 protein expression at 10 and 14 days further supporting the ability of HDACi to promote differentiation. HDACi exert different effects on primary compared with transformed DPCs and promote mineralization and differentiation events without cytotoxic effects. These novel data now highlight the potential in restorative dentistry for applying low concentrations of HDACi in vital pulp treatment." @default.
• W2007660474 created "2016-06-24" @default.
• W2007660474 creator A5014984356 @default.
• W2007660474 creator A5023804132 @default.
• W2007660474 creator A5028880412 @default.
• W2007660474 creator A5088299148 @default.
• W2007660474 date "2013-06-01" @default.
• W2007660474 modified "2023-10-17" @default.
• W2007660474 title "Histone deacetylase inhibitors epigenetically promote reparative events in primary dental pulp cells" @default.
• W2007660474 cites W137915467 @default.
• W2007660474 cites W1967018540 @default.
• W2007660474 cites W1974080203 @default.
• W2007660474 cites W1974090542 @default.
• W2007660474 cites W1976662121 @default.
• W2007660474 cites W1978664410 @default.
• W2007660474 cites W1979214289 @default.
• W2007660474 cites W1990801507 @default.
• W2007660474 cites W2001704880 @default.
• W2007660474 cites W2016946551 @default.
• W2007660474 cites W2024941123 @default.
• W2007660474 cites W2027619236 @default.
• W2007660474 cites W2031251066 @default.
• W2007660474 cites W2033542197 @default.
• W2007660474 cites W2035406121 @default.
• W2007660474 cites W2044780819 @default.
• W2007660474 cites W2047067007 @default.
• W2007660474 cites W2049876547 @default.
• W2007660474 cites W2050628283 @default.
• W2007660474 cites W2052816497 @default.
• W2007660474 cites W2057561198 @default.
• W2007660474 cites W2058013778 @default.
• W2007660474 cites W2074033312 @default.
• W2007660474 cites W2088553641 @default.
• W2007660474 cites W2088797295 @default.
• W2007660474 cites W2090381051 @default.
• W2007660474 cites W2094953245 @default.
• W2007660474 cites W2121039238 @default.
• W2007660474 cites W2125483185 @default.
• W2007660474 cites W2139135727 @default.
• W2007660474 cites W2146320180 @default.
• W2007660474 cites W2153936519 @default.
• W2007660474 cites W2160569622 @default.
• W2007660474 cites W2167118090 @default.
• W2007660474 cites W31775548 @default.
• W2007660474 doi "https://doi.org/10.1016/j.yexcr.2013.02.022" @default.
• W2007660474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23562654" @default.
• W2007660474 hasPublicationYear "2013" @default.
• W2007660474 type Work @default.
• W2007660474 sameAs 2007660474 @default.
• W2007660474 citedByCount "47" @default.
• W2007660474 countsByYear W20076604742014 @default.
• W2007660474 countsByYear W20076604742015 @default.
• W2007660474 countsByYear W20076604742016 @default.
• W2007660474 countsByYear W20076604742017 @default.
• W2007660474 countsByYear W20076604742018 @default.
• W2007660474 countsByYear W20076604742019 @default.
• W2007660474 countsByYear W20076604742020 @default.
• W2007660474 countsByYear W20076604742021 @default.
• W2007660474 countsByYear W20076604742022 @default.
• W2007660474 countsByYear W20076604742023 @default.
• W2007660474 crossrefType "journal-article" @default.
• W2007660474 hasAuthorship W2007660474A5014984356 @default.
• W2007660474 hasAuthorship W2007660474A5023804132 @default.
• W2007660474 hasAuthorship W2007660474A5028880412 @default.
• W2007660474 hasAuthorship W2007660474A5088299148 @default.
• W2007660474 hasConcept C104317684 @default.
• W2007660474 hasConcept C1491633281 @default.
• W2007660474 hasConcept C153911025 @default.
• W2007660474 hasConcept C203014093 @default.
• W2007660474 hasConcept C2776202225 @default.
• W2007660474 hasConcept C2777865847 @default.
• W2007660474 hasConcept C2778305200 @default.
• W2007660474 hasConcept C2780804394 @default.
• W2007660474 hasConcept C502942594 @default.
• W2007660474 hasConcept C53227056 @default.
• W2007660474 hasConcept C55493867 @default.
• W2007660474 hasConcept C62112901 @default.
• W2007660474 hasConcept C64927066 @default.
• W2007660474 hasConcept C86803240 @default.
• W2007660474 hasConcept C95444343 @default.
• W2007660474 hasConceptScore W2007660474C104317684 @default.
• W2007660474 hasConceptScore W2007660474C1491633281 @default.
• W2007660474 hasConceptScore W2007660474C153911025 @default.
• W2007660474 hasConceptScore W2007660474C203014093 @default.
• W2007660474 hasConceptScore W2007660474C2776202225 @default.
• W2007660474 hasConceptScore W2007660474C2777865847 @default.
• W2007660474 hasConceptScore W2007660474C2778305200 @default.
• W2007660474 hasConceptScore W2007660474C2780804394 @default.
• W2007660474 hasConceptScore W2007660474C502942594 @default.
• W2007660474 hasConceptScore W2007660474C53227056 @default.
• W2007660474 hasConceptScore W2007660474C55493867 @default.
• W2007660474 hasConceptScore W2007660474C62112901 @default.
• W2007660474 hasConceptScore W2007660474C64927066 @default.
• W2007660474 hasConceptScore W2007660474C86803240 @default.
• W2007660474 hasConceptScore W2007660474C95444343 @default.
• W2007660474 hasIssue "10" @default.
• W2007660474 hasLocation W20076604741 @default.
• W2007660474 hasLocation W20076604742 @default.

• next