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- W2007662493 abstract "Although some mathematical models for estimating basic population parameters by means of lethal allelism analysis are already available, all of them require a knowledge of the values of p∞, (rate of allelism of independently - arisen lethal genes), n (number of loci in the chromosome subject to lethal mutation) and μ (rate of lethal mutation per generation per chromosome). The experimental estimate of these values poses a serious problem. The present study aims to quantify the extent to which variation in the experimentally obtained estimates of p∞, n and μ can influence the estimated values of certain important population parameters such as Ne (effective population size), s+F (mean selective disadvantage of heterozygotes plus the inbreeding coefficient of the type FID) and h (average reduction in fitness or heterozygotes carrying a lethal chromosome), in a colonizing (Gilroy, California) and a Palearctic (Bordils, Spain) population of Drosophila subosbscura. It can be concluded that although the mathematical models are necessarily an oversimplification of the biological reality they aim to describe, they are still useful tools for the comparison of the genetic structure of different populations.ZusammenfassungDie Allelierate von Letalfaktoren bei Drosophila subobscura und die Schwierigkeiten, daraus wicbtige Populations-Parameter zu ermittelnAus der Analyse von Haufigkeit und Allelierate von Letalfaktoren, konnen eine Reihe von wich-tigen Populations-Parametern abgeleitet werden. Dafur gibt es bereits einige gute mathematische Modelle. Zur Berechnung mus man jedoch folgende Werte kennen: Wahrscheinlichkeit fur Alle-lie bei Neumutationen (p∞), Anzahl der Gene, die zu Letalallelen mutieren konnen in dem gerade analysierten Chromosomenabschnitt (n), und die Letalmutationsrate pro Chromosom pro Generation (μ).Die experimentelle Ermittlung dieser Werte wirft einige Probleme auf. Die hier vorgelegte Arbeit untersucht inwieweit Unterschiede in den Schatzwerten fur p∞, n und μ die aus den Mo-dellen resultierenden Bevolkerungsdaten, wie z. B. die effektive Populationsgrose (Ne), der durchschnittliche Heterozygotennachteil bei gegebenem Inzuchtkoeffizienten FID{S+F) und die durchschnittliche Fitness-Reduktion von Letal-Heterozygoten (h), verandern. Als Beispiel werden Werte aus zwei Populationen von Drosophila subobscura vorgestellt; eine der Populatio-nen (Gilroy/Californien) ist eine neu in den USA kolonisierende Population, die andere (Bordils/Spanien) aus dem palaearktischen Zentrum des Artbereichs. Die Modelle sind sicher eine Vereinfachung der biologischen Realitat, aber die eefundenen Werte gestatten es doch, die geneti-sche Struktur der beiden Populationen zu vergleichen." @default.
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- W2007662493 title "Lethal allelism in Drosophila subobscura: difficulties in the estimation of certain population parameters" @default.
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