FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007662671> ?p ?o ?g. }

• W2007662671 endingPage "780" @default.
• W2007662671 startingPage "775" @default.
• W2007662671 abstract "Hepatic stellate cells (HSCs) have been known to play a key role in the pathogenesis of liver fibrosis. In the course of screening antifibrotic activity of natural products employing HSC-T6, a rat hepatic stellate cell line as an in vitro assay system, the methanolic extract of aerial parts of Eclipta prostrata L. showed significant inhibitory activity on HSCs proliferation. Activity-guided fractionation led to the isolation of five oleanane-type triterpenoids, echinocystic acid (1), eclalbasaponin II (2), eclalbasaponin V (3), eclalbasaponin I (4) and eclalbasaponin III (5), which are all echinocystic acid derivatives. Among the five echinocystic acid derivatives isolated, echinocystic acid (1) and eclalbasaponin II (2) significantly inhibited the proliferation of HSCs in dose- and time-dependent manners. Our present study also suggests the importance of free carboxylic acid at C-28 position in echinocystic acid derivatives for the antifibrotic activity. Taken together, antifibrotic activity of E. prostrata and its triterpenoids might suggest the therapeutic potentials against liver fibrosis." @default.
• W2007662671 created "2016-06-24" @default.
• W2007662671 creator A5023534856 @default.
• W2007662671 creator A5055736461 @default.
• W2007662671 creator A5064866338 @default.
• W2007662671 creator A5072275470 @default.
• W2007662671 creator A5073629644 @default.
• W2007662671 creator A5087561050 @default.
• W2007662671 date "2008-09-01" @default.
• W2007662671 modified "2023-10-17" @default.
• W2007662671 title "Antiproliferative activity of triterpenoids from Eclipta prostrata on hepatic stellate cells" @default.
• W2007662671 cites W1965134586 @default.
• W2007662671 cites W1965660130 @default.
• W2007662671 cites W1967917547 @default.
• W2007662671 cites W1972676329 @default.
• W2007662671 cites W1977695060 @default.
• W2007662671 cites W1991863368 @default.
• W2007662671 cites W1992006494 @default.
• W2007662671 cites W1992979528 @default.
• W2007662671 cites W1995818362 @default.
• W2007662671 cites W2048225676 @default.
• W2007662671 cites W2050767955 @default.
• W2007662671 cites W2054176089 @default.
• W2007662671 cites W2058162754 @default.
• W2007662671 cites W2080371822 @default.
• W2007662671 cites W2128871636 @default.
• W2007662671 cites W2155685353 @default.
• W2007662671 cites W2158129157 @default.
• W2007662671 cites W2188009983 @default.
• W2007662671 cites W2316173260 @default.
• W2007662671 cites W2509099452 @default.
• W2007662671 cites W4255712601 @default.
• W2007662671 cites W955787779 @default.
• W2007662671 doi "https://doi.org/10.1016/j.phymed.2007.10.004" @default.
• W2007662671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18061418" @default.
• W2007662671 hasPublicationYear "2008" @default.
• W2007662671 type Work @default.
• W2007662671 sameAs 2007662671 @default.
• W2007662671 citedByCount "46" @default.
• W2007662671 countsByYear W20076626712012 @default.
• W2007662671 countsByYear W20076626712013 @default.
• W2007662671 countsByYear W20076626712014 @default.
• W2007662671 countsByYear W20076626712015 @default.
• W2007662671 countsByYear W20076626712016 @default.
• W2007662671 countsByYear W20076626712017 @default.
• W2007662671 countsByYear W20076626712018 @default.
• W2007662671 countsByYear W20076626712019 @default.
• W2007662671 countsByYear W20076626712020 @default.
• W2007662671 countsByYear W20076626712021 @default.
• W2007662671 countsByYear W20076626712022 @default.
• W2007662671 countsByYear W20076626712023 @default.
• W2007662671 crossrefType "journal-article" @default.
• W2007662671 hasAuthorship W2007662671A5023534856 @default.
• W2007662671 hasAuthorship W2007662671A5055736461 @default.
• W2007662671 hasAuthorship W2007662671A5064866338 @default.
• W2007662671 hasAuthorship W2007662671A5072275470 @default.
• W2007662671 hasAuthorship W2007662671A5073629644 @default.
• W2007662671 hasAuthorship W2007662671A5087561050 @default.
• W2007662671 hasConcept C107585567 @default.
• W2007662671 hasConcept C134018914 @default.
• W2007662671 hasConcept C142724271 @default.
• W2007662671 hasConcept C176891718 @default.
• W2007662671 hasConcept C185592680 @default.
• W2007662671 hasConcept C202751555 @default.
• W2007662671 hasConcept C2780559512 @default.
• W2007662671 hasConcept C2993667909 @default.
• W2007662671 hasConcept C55493867 @default.
• W2007662671 hasConcept C556039675 @default.
• W2007662671 hasConcept C71240020 @default.
• W2007662671 hasConcept C71924100 @default.
• W2007662671 hasConcept C86803240 @default.
• W2007662671 hasConcept C98274493 @default.
• W2007662671 hasConceptScore W2007662671C107585567 @default.
• W2007662671 hasConceptScore W2007662671C134018914 @default.
• W2007662671 hasConceptScore W2007662671C142724271 @default.
• W2007662671 hasConceptScore W2007662671C176891718 @default.
• W2007662671 hasConceptScore W2007662671C185592680 @default.
• W2007662671 hasConceptScore W2007662671C202751555 @default.
• W2007662671 hasConceptScore W2007662671C2780559512 @default.
• W2007662671 hasConceptScore W2007662671C2993667909 @default.
• W2007662671 hasConceptScore W2007662671C55493867 @default.
• W2007662671 hasConceptScore W2007662671C556039675 @default.
• W2007662671 hasConceptScore W2007662671C71240020 @default.
• W2007662671 hasConceptScore W2007662671C71924100 @default.
• W2007662671 hasConceptScore W2007662671C86803240 @default.
• W2007662671 hasConceptScore W2007662671C98274493 @default.
• W2007662671 hasIssue "9" @default.
• W2007662671 hasLocation W20076626711 @default.
• W2007662671 hasLocation W20076626712 @default.
• W2007662671 hasOpenAccess W2007662671 @default.
• W2007662671 hasPrimaryLocation W20076626711 @default.
• W2007662671 hasRelatedWork W1455485982 @default.
• W2007662671 hasRelatedWork W163630733 @default.
• W2007662671 hasRelatedWork W196211339 @default.
• W2007662671 hasRelatedWork W2091393830 @default.
• W2007662671 hasRelatedWork W2110625531 @default.
• W2007662671 hasRelatedWork W3038928394 @default.
• W2007662671 hasRelatedWork W4234984279 @default.

• next