Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007667022> ?p ?o ?g. }
- W2007667022 endingPage "88" @default.
- W2007667022 startingPage "82" @default.
- W2007667022 abstract "Cholesterol is essential for the growth and function of all mammalian cells, but abnormally increased blood cholesterol is a major risk factor for atherosclerotic cardiovascular disease. ATP-binding cassette (ABC) transporters G5 (ABCG5) and G8 (ABCG8) form an obligate heterodimer that limits intestinal absorption and facilitates biliary secretion of cholesterol and phytosterols. Consistent with their function, ABCG5 and ABCG8 are located on the apical membrane of enterocytes and hepatocytes. Liver X receptor is the major positive regulator of ABCG5 and ABCG8 expression. Mutations in either of the two genes cause sitosterolemia, a condition in which cholesterol and plant sterols accumulate in the circulation leading to premature cardiovascular disease. Overexpression of ABCG5 and ABCG8 in mice retards diet-induced atherosclerosis because of reduced circulating and hepatic cholesterol. In the current review, we summarize recent developments and propose a future framework that provides new perspectives on the regulation of cholesterol metabolism and treatment of atherosclerotic cardiovascular disease." @default.
- W2007667022 created "2016-06-24" @default.
- W2007667022 creator A5002893951 @default.
- W2007667022 creator A5034300226 @default.
- W2007667022 creator A5039493947 @default.
- W2007667022 creator A5056942753 @default.
- W2007667022 creator A5058966019 @default.
- W2007667022 creator A5067798062 @default.
- W2007667022 date "2014-01-01" @default.
- W2007667022 modified "2023-10-16" @default.
- W2007667022 title "ABCG5/ABCG8 in cholesterol excretion and atherosclerosis" @default.
- W2007667022 cites W1501370853 @default.
- W2007667022 cites W1719644483 @default.
- W2007667022 cites W1848109599 @default.
- W2007667022 cites W1966974462 @default.
- W2007667022 cites W1977300136 @default.
- W2007667022 cites W1978639613 @default.
- W2007667022 cites W1982971013 @default.
- W2007667022 cites W1991264861 @default.
- W2007667022 cites W1992177227 @default.
- W2007667022 cites W1994200743 @default.
- W2007667022 cites W1995388923 @default.
- W2007667022 cites W1995905776 @default.
- W2007667022 cites W1996534604 @default.
- W2007667022 cites W1997981911 @default.
- W2007667022 cites W2000744235 @default.
- W2007667022 cites W2002427254 @default.
- W2007667022 cites W2012070467 @default.
- W2007667022 cites W2012522540 @default.
- W2007667022 cites W2018515385 @default.
- W2007667022 cites W2019372029 @default.
- W2007667022 cites W2022019083 @default.
- W2007667022 cites W2022856300 @default.
- W2007667022 cites W2023964045 @default.
- W2007667022 cites W2027663543 @default.
- W2007667022 cites W2034398538 @default.
- W2007667022 cites W2047148112 @default.
- W2007667022 cites W2048971924 @default.
- W2007667022 cites W2049469987 @default.
- W2007667022 cites W2063801481 @default.
- W2007667022 cites W2064876311 @default.
- W2007667022 cites W2066342412 @default.
- W2007667022 cites W2069302647 @default.
- W2007667022 cites W2069551187 @default.
- W2007667022 cites W2071897221 @default.
- W2007667022 cites W2080441316 @default.
- W2007667022 cites W2095059518 @default.
- W2007667022 cites W2098984119 @default.
- W2007667022 cites W2099378835 @default.
- W2007667022 cites W2099865679 @default.
- W2007667022 cites W2108227278 @default.
- W2007667022 cites W2109717763 @default.
- W2007667022 cites W2110448941 @default.
- W2007667022 cites W2121829887 @default.
- W2007667022 cites W2122812989 @default.
- W2007667022 cites W2125377218 @default.
- W2007667022 cites W2127039457 @default.
- W2007667022 cites W2127187069 @default.
- W2007667022 cites W2132029416 @default.
- W2007667022 cites W2133889486 @default.
- W2007667022 cites W2134606187 @default.
- W2007667022 cites W2140125287 @default.
- W2007667022 cites W2143812366 @default.
- W2007667022 cites W2144050182 @default.
- W2007667022 cites W2153218268 @default.
- W2007667022 cites W2157496533 @default.
- W2007667022 cites W2159518879 @default.
- W2007667022 cites W2168450753 @default.
- W2007667022 cites W2168569267 @default.
- W2007667022 cites W3191094111 @default.
- W2007667022 cites W4247935329 @default.
- W2007667022 cites W4251360714 @default.
- W2007667022 cites W69033956 @default.
- W2007667022 cites W1967537209 @default.
- W2007667022 cites W2089105116 @default.
- W2007667022 doi "https://doi.org/10.1016/j.cca.2013.11.010" @default.
- W2007667022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24252657" @default.
- W2007667022 hasPublicationYear "2014" @default.
- W2007667022 type Work @default.
- W2007667022 sameAs 2007667022 @default.
- W2007667022 citedByCount "128" @default.
- W2007667022 countsByYear W20076670222014 @default.
- W2007667022 countsByYear W20076670222015 @default.
- W2007667022 countsByYear W20076670222016 @default.
- W2007667022 countsByYear W20076670222017 @default.
- W2007667022 countsByYear W20076670222018 @default.
- W2007667022 countsByYear W20076670222019 @default.
- W2007667022 countsByYear W20076670222020 @default.
- W2007667022 countsByYear W20076670222021 @default.
- W2007667022 countsByYear W20076670222022 @default.
- W2007667022 countsByYear W20076670222023 @default.
- W2007667022 crossrefType "journal-article" @default.
- W2007667022 hasAuthorship W2007667022A5002893951 @default.
- W2007667022 hasAuthorship W2007667022A5034300226 @default.
- W2007667022 hasAuthorship W2007667022A5039493947 @default.
- W2007667022 hasAuthorship W2007667022A5056942753 @default.
- W2007667022 hasAuthorship W2007667022A5058966019 @default.
- W2007667022 hasAuthorship W2007667022A5067798062 @default.