Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007672028> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2007672028 endingPage "171" @default.
- W2007672028 startingPage "161" @default.
- W2007672028 abstract "2-Mercaptobenzimidazole (2-MBI), used in rubber processing, is a suspect carcinogen structurally related to ethylene thiourea. The inhalation toxicity of 2-MBI was evaluated in male and female F344/N rats exposed 6 hr/day, 5 days/week to respirable aerosols generated by spray atomization of aqueous suspensions of the 2-MBI powder and subsequent drying of the resulting aerosols. Twelve exposures at target concentrations of 0, 6.3, 12.5, 25.0, 50.0, or 100 mg/m3 of 2-MBI produced a dose-related reduction in body weight gains, thyroid follicular cell hyperplasia, adrenal cortex fatty change, and pituitary atrophy. Sub-chronic exposures were conducted at target concentrations of 0, 3.1, 6.2, 12.5, 25.0, and 50.0 mg/m3 of 2-MBI. Rats at greater than or equal to 25 mg/m3 displayed hunched posture, hypoactivity, and reduced body weight gain, with compound related mortality at the highest exposure level. Anemia; increased SGPT, SGOT, alkaline phosphatase, sorbitol dehydrogenase, BUN, and cholesterol; and reduced free fatty acid were seen in rats at greater than or equal to 25 mg/m3. Increased thyroid weight and thyroid follicular cell hyperplasia were noted in both sexes at greater than or equal to 6.2 mg/m3, with reduced triiodothyronine and thyroxine levels in both sexes at greater than or equal to 12.5 mg/m3. Thyroid follicular cell hyperplasia was also seen in rats at 3.1 mg/m3. Thymus weights were significantly reduced in both sexes at all exposure levels with liver weight increases at greater than or equal to 6.2 mg/m3. Exposure-related histopathologic changes included pituitary cytoplasmic vacuolization, adrenal cortex necrosis, lymphoid depletion, thymic atrophy, liver cell hypertrophy, renal mineralization and tubular atrophy, and hypocellularity of the bone marrow." @default.
- W2007672028 created "2016-06-24" @default.
- W2007672028 creator A5008200814 @default.
- W2007672028 creator A5010665011 @default.
- W2007672028 creator A5028163989 @default.
- W2007672028 creator A5043393394 @default.
- W2007672028 creator A5068206788 @default.
- W2007672028 creator A5075051394 @default.
- W2007672028 creator A5079741334 @default.
- W2007672028 date "1991-01-01" @default.
- W2007672028 modified "2023-09-27" @default.
- W2007672028 title "Prechronic inhalation toxicity studies of 2-mercaptobenzimidazole (2-MBI) in F344/N rats*1" @default.
- W2007672028 cites W132590113 @default.
- W2007672028 cites W1865924587 @default.
- W2007672028 cites W1973713220 @default.
- W2007672028 cites W2045873882 @default.
- W2007672028 cites W2069709516 @default.
- W2007672028 cites W2086627938 @default.
- W2007672028 cites W2111621105 @default.
- W2007672028 cites W2288219624 @default.
- W2007672028 cites W2328056838 @default.
- W2007672028 cites W939259490 @default.
- W2007672028 doi "https://doi.org/10.1016/0272-0590(91)90144-s" @default.
- W2007672028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2019341" @default.
- W2007672028 hasPublicationYear "1991" @default.
- W2007672028 type Work @default.
- W2007672028 sameAs 2007672028 @default.
- W2007672028 citedByCount "9" @default.
- W2007672028 countsByYear W20076720282014 @default.
- W2007672028 countsByYear W20076720282015 @default.
- W2007672028 countsByYear W20076720282018 @default.
- W2007672028 countsByYear W20076720282021 @default.
- W2007672028 crossrefType "journal-article" @default.
- W2007672028 hasAuthorship W2007672028A5008200814 @default.
- W2007672028 hasAuthorship W2007672028A5010665011 @default.
- W2007672028 hasAuthorship W2007672028A5028163989 @default.
- W2007672028 hasAuthorship W2007672028A5043393394 @default.
- W2007672028 hasAuthorship W2007672028A5068206788 @default.
- W2007672028 hasAuthorship W2007672028A5075051394 @default.
- W2007672028 hasAuthorship W2007672028A5079741334 @default.
- W2007672028 hasConcept C105702510 @default.
- W2007672028 hasConcept C126322002 @default.
- W2007672028 hasConcept C134018914 @default.
- W2007672028 hasConcept C160160445 @default.
- W2007672028 hasConcept C181199279 @default.
- W2007672028 hasConcept C185592680 @default.
- W2007672028 hasConcept C187785154 @default.
- W2007672028 hasConcept C2776779347 @default.
- W2007672028 hasConcept C2776954882 @default.
- W2007672028 hasConcept C2777562237 @default.
- W2007672028 hasConcept C2777905771 @default.
- W2007672028 hasConcept C29730261 @default.
- W2007672028 hasConcept C526584372 @default.
- W2007672028 hasConcept C55493867 @default.
- W2007672028 hasConcept C71924100 @default.
- W2007672028 hasConceptScore W2007672028C105702510 @default.
- W2007672028 hasConceptScore W2007672028C126322002 @default.
- W2007672028 hasConceptScore W2007672028C134018914 @default.
- W2007672028 hasConceptScore W2007672028C160160445 @default.
- W2007672028 hasConceptScore W2007672028C181199279 @default.
- W2007672028 hasConceptScore W2007672028C185592680 @default.
- W2007672028 hasConceptScore W2007672028C187785154 @default.
- W2007672028 hasConceptScore W2007672028C2776779347 @default.
- W2007672028 hasConceptScore W2007672028C2776954882 @default.
- W2007672028 hasConceptScore W2007672028C2777562237 @default.
- W2007672028 hasConceptScore W2007672028C2777905771 @default.
- W2007672028 hasConceptScore W2007672028C29730261 @default.
- W2007672028 hasConceptScore W2007672028C526584372 @default.
- W2007672028 hasConceptScore W2007672028C55493867 @default.
- W2007672028 hasConceptScore W2007672028C71924100 @default.
- W2007672028 hasIssue "1" @default.
- W2007672028 hasLocation W20076720281 @default.
- W2007672028 hasLocation W20076720282 @default.
- W2007672028 hasOpenAccess W2007672028 @default.
- W2007672028 hasPrimaryLocation W20076720281 @default.
- W2007672028 hasRelatedWork W1981968121 @default.
- W2007672028 hasRelatedWork W2010645160 @default.
- W2007672028 hasRelatedWork W2011960454 @default.
- W2007672028 hasRelatedWork W2043899786 @default.
- W2007672028 hasRelatedWork W2060603500 @default.
- W2007672028 hasRelatedWork W2072870574 @default.
- W2007672028 hasRelatedWork W2155312245 @default.
- W2007672028 hasRelatedWork W2163236351 @default.
- W2007672028 hasRelatedWork W2411536504 @default.
- W2007672028 hasRelatedWork W2748952813 @default.
- W2007672028 hasVolume "16" @default.
- W2007672028 isParatext "false" @default.
- W2007672028 isRetracted "false" @default.
- W2007672028 magId "2007672028" @default.
- W2007672028 workType "article" @default.