Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007672332> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2007672332 endingPage "43" @default.
- W2007672332 startingPage "35" @default.
- W2007672332 abstract "The unilamellar liposomal formulation of amphotericin B, AmBisome, is composed of hydrogenated soy phosphatidylcholine, distearoyl phosphatidylglycerol and cholesterol. Early studies of its efficacy in an open design showed that remissions could be induced in candidosis and aspergillosis and that doses of up to 5 mg/kg could be used. Adverse events were infrequent, with the main abnormality seen being hypokalaemia in about 18% of patients. Subsequent developments have extended this work. AmBisome has been used in two open studies of patients with invasive aspergillosis; in one of these remission was achieved in 77% of 17 patients with confirmed infection who had failed to respond to conventional amphotericin B. In AIDS patients with cryptococcosis AmBisome given for 6 weeks at 3 mg/kg daily produced mycological remission of meningitis in 67%. Other infections treated with the drug include zygomycete (mucormycosis) and Fusarium infections. AmBisome has also been used as preventative therapy in bone marrow transplant recipients and was found to reduce fungal colonisation rates. There were fewer systemic fungal infections in the treated versus placebo groups although this did not achieve statistical significance. Lack of renal and liver toxicity or anaemia has been confirmed in subsequent studies. In addition febrile reactions to the AmBisome are rare. The drug has also been used effectively in children, including infants, with systemic fungal infections. In visceral leishmaniasis patients, including HIV positive individuals, remissions have been obtained using drug regimens of 1-2 mg/kg of 2.1 days and 3 mg/kg for 10 days." @default.
- W2007672332 created "2016-06-24" @default.
- W2007672332 creator A5046756604 @default.
- W2007672332 date "1994-05-01" @default.
- W2007672332 modified "2023-10-16" @default.
- W2007672332 title "Liposomal amphotericin B, AmBisome" @default.
- W2007672332 cites W1532352434 @default.
- W2007672332 cites W1986516709 @default.
- W2007672332 cites W1997032499 @default.
- W2007672332 cites W2005581514 @default.
- W2007672332 cites W2012504003 @default.
- W2007672332 cites W2012667050 @default.
- W2007672332 cites W2020118720 @default.
- W2007672332 cites W2027779850 @default.
- W2007672332 cites W2037064781 @default.
- W2007672332 cites W2037587995 @default.
- W2007672332 cites W2046424277 @default.
- W2007672332 cites W2053261047 @default.
- W2007672332 cites W2065464305 @default.
- W2007672332 cites W2083620969 @default.
- W2007672332 cites W2084068955 @default.
- W2007672332 cites W2091113362 @default.
- W2007672332 cites W2113103505 @default.
- W2007672332 cites W2119390272 @default.
- W2007672332 cites W2120541149 @default.
- W2007672332 cites W2131865591 @default.
- W2007672332 cites W2159312946 @default.
- W2007672332 cites W2330397459 @default.
- W2007672332 doi "https://doi.org/10.1016/s0163-4453(94)95956-0" @default.
- W2007672332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8077689" @default.
- W2007672332 hasPublicationYear "1994" @default.
- W2007672332 type Work @default.
- W2007672332 sameAs 2007672332 @default.
- W2007672332 citedByCount "68" @default.
- W2007672332 countsByYear W20076723322012 @default.
- W2007672332 countsByYear W20076723322014 @default.
- W2007672332 countsByYear W20076723322016 @default.
- W2007672332 countsByYear W20076723322018 @default.
- W2007672332 countsByYear W20076723322020 @default.
- W2007672332 countsByYear W20076723322021 @default.
- W2007672332 countsByYear W20076723322022 @default.
- W2007672332 countsByYear W20076723322023 @default.
- W2007672332 crossrefType "journal-article" @default.
- W2007672332 hasAuthorship W2007672332A5046756604 @default.
- W2007672332 hasConcept C126322002 @default.
- W2007672332 hasConcept C141071460 @default.
- W2007672332 hasConcept C16005928 @default.
- W2007672332 hasConcept C197934379 @default.
- W2007672332 hasConcept C203014093 @default.
- W2007672332 hasConcept C2776391196 @default.
- W2007672332 hasConcept C2776555147 @default.
- W2007672332 hasConcept C2778689377 @default.
- W2007672332 hasConcept C2779548794 @default.
- W2007672332 hasConcept C2779629538 @default.
- W2007672332 hasConcept C2780402444 @default.
- W2007672332 hasConcept C2909039274 @default.
- W2007672332 hasConcept C71924100 @default.
- W2007672332 hasConcept C90924648 @default.
- W2007672332 hasConceptScore W2007672332C126322002 @default.
- W2007672332 hasConceptScore W2007672332C141071460 @default.
- W2007672332 hasConceptScore W2007672332C16005928 @default.
- W2007672332 hasConceptScore W2007672332C197934379 @default.
- W2007672332 hasConceptScore W2007672332C203014093 @default.
- W2007672332 hasConceptScore W2007672332C2776391196 @default.
- W2007672332 hasConceptScore W2007672332C2776555147 @default.
- W2007672332 hasConceptScore W2007672332C2778689377 @default.
- W2007672332 hasConceptScore W2007672332C2779548794 @default.
- W2007672332 hasConceptScore W2007672332C2779629538 @default.
- W2007672332 hasConceptScore W2007672332C2780402444 @default.
- W2007672332 hasConceptScore W2007672332C2909039274 @default.
- W2007672332 hasConceptScore W2007672332C71924100 @default.
- W2007672332 hasConceptScore W2007672332C90924648 @default.
- W2007672332 hasLocation W20076723321 @default.
- W2007672332 hasLocation W20076723322 @default.
- W2007672332 hasOpenAccess W2007672332 @default.
- W2007672332 hasPrimaryLocation W20076723321 @default.
- W2007672332 hasRelatedWork W2072809427 @default.
- W2007672332 hasRelatedWork W2083068805 @default.
- W2007672332 hasRelatedWork W2090614256 @default.
- W2007672332 hasRelatedWork W2093449277 @default.
- W2007672332 hasRelatedWork W2105573037 @default.
- W2007672332 hasRelatedWork W2134294475 @default.
- W2007672332 hasRelatedWork W2138933525 @default.
- W2007672332 hasRelatedWork W2147221460 @default.
- W2007672332 hasRelatedWork W2410657553 @default.
- W2007672332 hasRelatedWork W2906379458 @default.
- W2007672332 hasVolume "28" @default.
- W2007672332 isParatext "false" @default.
- W2007672332 isRetracted "false" @default.
- W2007672332 magId "2007672332" @default.
- W2007672332 workType "article" @default.