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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007673642> ?p ?o ?g. }

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• W2007673642 abstract "The mechanism by which tumor necrosis factor-alpha (TNF) differentially modulates type I diabetes mellitus in the nonobese diabetic (NOD) mouse is not well understood. CD4+CD25+ T cells have been implicated as mediators of self-tolerance. We show (i) NOD mice have a relative deficiency of CD4+CD25+ T cells in thymus and spleen; (ii) administration of TNF or anti-TNF to NOD mice can modulate levels of this population consistent with their observed differential age-dependent effects on diabetes in the NOD mouse; (iii) CD4+CD25+ T cells from NOD mice treated neonatally with TNF show compromised effector function in a transfer system, whereas those treated neonatally with anti-TNF show no alteration in ability to prevent diabetes; and (iv) repeated injection of CD4+CD25+ T cells into neonatal NOD mice delays diabetes onset for as long as supplementation occurred. These data suggest that alterations in the number and function of CD4+CD25+ T cells may be one mechanism by which TNF and anti-TNF modulate type I diabetes mellitus in NOD mice." @default.
• W2007673642 created "2016-06-24" @default.
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• W2007673642 date "2002-09-09" @default.
• W2007673642 modified "2023-09-30" @default.
• W2007673642 title "Tumor necrosis factor-α regulation of CD4⁺C25⁺T cell levels in NOD mice" @default.
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• W2007673642 doi "https://doi.org/10.1073/pnas.172382999" @default.
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