FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007676743> ?p ?o ?g. }

• W2007676743 endingPage "75" @default.
• W2007676743 startingPage "68" @default.
• W2007676743 abstract "Extracorporeal photochemotherapy (ECP) is a medical procedure effective in the treatment of several different T-cell mediated diseases such as cutaneous T-cell lymphoma and Graft-versus-Host Disease. During ECP treatment the patient’s blood is processed by means of a cell separator to collect leukocytes (leukapheresis), mostly lymphocytes and monocytes, which are then incubated with the photoactive drug 8-methoxypsoralen (8-MOP), exposed to ultraviolet-A light (UV-A) and reinfused to the patient. It has been suggested that during ECP not only UV-A irradiation but also changes in the environmental condition may be relevant. Although ECP has been shown to have an in-vivo immunomodulatory effect, the mechanisms through which ECP exerts its effect remain elusive. One of the reasons for this incomplete knowledge is the absence of a reliable model for ECP. In order to investigate the effect of ECP on the peripheral immune system, we developed a new device which mimics the complete ECP cycle including blood transit through the cell separator. Peripheral blood samples (50 ml) were obtained from volunteers and processed using a peristaltic pump. Peripheral blood mononuclear cells (PBMC) were then collected and treated with 8-MOP and UV-A under the same conditions used for the patients’ therapy. Using this strategy we investigated 8-MOP, UV-A and their combined effect on the production of the pro-inflammatory cytokines interferon-γ (IFN-γ), interleukine-2 (IL-2) and tumor necrosis factor-α (TNF-α) in PBMC with and without polyclonal stimulation. We firstly demonstrated that our device does not affect total red and white blood cell counts. After 8-MOP and UV-A irradiation a significant decrease was observed in both activated CD4+ and CD8+ T lymphocytes producing IFN-γ, IL-2 and TNF-α. Our findings are in line with those previously obtained in humans after complete ECP treatment, thus suggesting that our newly developed device is suitable for investigating the mechanism of action of ECP ex-vivo." @default.
• W2007676743 created "2016-06-24" @default.
• W2007676743 creator A5007961811 @default.
• W2007676743 creator A5062847026 @default.
• W2007676743 creator A5066180999 @default.
• W2007676743 creator A5066817055 @default.
• W2007676743 creator A5067601421 @default.
• W2007676743 creator A5078228530 @default.
• W2007676743 date "2007-07-01" @default.
• W2007676743 modified "2023-10-17" @default.
• W2007676743 title "A new device to study ex-vivo the effects of extracorporeal photochemotherapy on the immune system" @default.
• W2007676743 cites W1496485913 @default.
• W2007676743 cites W1550483876 @default.
• W2007676743 cites W1973696041 @default.
• W2007676743 cites W1989850302 @default.
• W2007676743 cites W1993422833 @default.
• W2007676743 cites W1995622152 @default.
• W2007676743 cites W2018985011 @default.
• W2007676743 cites W2019072400 @default.
• W2007676743 cites W2039198900 @default.
• W2007676743 cites W2040111293 @default.
• W2007676743 cites W2042106673 @default.
• W2007676743 cites W2044507771 @default.
• W2007676743 cites W2047021387 @default.
• W2007676743 cites W2065244027 @default.
• W2007676743 cites W2077844381 @default.
• W2007676743 cites W2088935309 @default.
• W2007676743 cites W2094795204 @default.
• W2007676743 cites W2097484462 @default.
• W2007676743 cites W2111127937 @default.
• W2007676743 cites W2116616281 @default.
• W2007676743 cites W2116873923 @default.
• W2007676743 cites W2337557724 @default.
• W2007676743 cites W2341292562 @default.
• W2007676743 doi "https://doi.org/10.1016/j.jphotobiol.2007.05.001" @default.
• W2007676743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17583527" @default.
• W2007676743 hasPublicationYear "2007" @default.
• W2007676743 type Work @default.
• W2007676743 sameAs 2007676743 @default.
• W2007676743 citedByCount "3" @default.
• W2007676743 crossrefType "journal-article" @default.
• W2007676743 hasAuthorship W2007676743A5007961811 @default.
• W2007676743 hasAuthorship W2007676743A5062847026 @default.
• W2007676743 hasAuthorship W2007676743A5066180999 @default.
• W2007676743 hasAuthorship W2007676743A5066817055 @default.
• W2007676743 hasAuthorship W2007676743A5067601421 @default.
• W2007676743 hasAuthorship W2007676743A5078228530 @default.
• W2007676743 hasConcept C10205521 @default.
• W2007676743 hasConcept C137061746 @default.
• W2007676743 hasConcept C141071460 @default.
• W2007676743 hasConcept C150903083 @default.
• W2007676743 hasConcept C17991360 @default.
• W2007676743 hasConcept C185592680 @default.
• W2007676743 hasConcept C202751555 @default.
• W2007676743 hasConcept C203014093 @default.
• W2007676743 hasConcept C207001950 @default.
• W2007676743 hasConcept C26291073 @default.
• W2007676743 hasConcept C2776090121 @default.
• W2007676743 hasConcept C2777371436 @default.
• W2007676743 hasConcept C2779053233 @default.
• W2007676743 hasConcept C2779338263 @default.
• W2007676743 hasConcept C2779972918 @default.
• W2007676743 hasConcept C2779979121 @default.
• W2007676743 hasConcept C2781468836 @default.
• W2007676743 hasConcept C28328180 @default.
• W2007676743 hasConcept C2909962264 @default.
• W2007676743 hasConcept C2911091166 @default.
• W2007676743 hasConcept C54355233 @default.
• W2007676743 hasConcept C55493867 @default.
• W2007676743 hasConcept C71924100 @default.
• W2007676743 hasConcept C86803240 @default.
• W2007676743 hasConcept C8891405 @default.
• W2007676743 hasConcept C98274493 @default.
• W2007676743 hasConceptScore W2007676743C10205521 @default.
• W2007676743 hasConceptScore W2007676743C137061746 @default.
• W2007676743 hasConceptScore W2007676743C141071460 @default.
• W2007676743 hasConceptScore W2007676743C150903083 @default.
• W2007676743 hasConceptScore W2007676743C17991360 @default.
• W2007676743 hasConceptScore W2007676743C185592680 @default.
• W2007676743 hasConceptScore W2007676743C202751555 @default.
• W2007676743 hasConceptScore W2007676743C203014093 @default.
• W2007676743 hasConceptScore W2007676743C207001950 @default.
• W2007676743 hasConceptScore W2007676743C26291073 @default.
• W2007676743 hasConceptScore W2007676743C2776090121 @default.
• W2007676743 hasConceptScore W2007676743C2777371436 @default.
• W2007676743 hasConceptScore W2007676743C2779053233 @default.
• W2007676743 hasConceptScore W2007676743C2779338263 @default.
• W2007676743 hasConceptScore W2007676743C2779972918 @default.
• W2007676743 hasConceptScore W2007676743C2779979121 @default.
• W2007676743 hasConceptScore W2007676743C2781468836 @default.
• W2007676743 hasConceptScore W2007676743C28328180 @default.
• W2007676743 hasConceptScore W2007676743C2909962264 @default.
• W2007676743 hasConceptScore W2007676743C2911091166 @default.
• W2007676743 hasConceptScore W2007676743C54355233 @default.
• W2007676743 hasConceptScore W2007676743C55493867 @default.
• W2007676743 hasConceptScore W2007676743C71924100 @default.
• W2007676743 hasConceptScore W2007676743C86803240 @default.
• W2007676743 hasConceptScore W2007676743C8891405 @default.

• next