FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007678016> ?p ?o ?g. }

• W2007678016 endingPage "707" @default.
• W2007678016 startingPage "701" @default.
• W2007678016 abstract "Previous studies have shown that mitochondrial DNA (mtDNA) haplogroup J is significantly over-represented in healthy centenarians with respect to younger controls, thus suggesting that this haplogroup predisposes to successful aging and longevity. On the other hand, the same haplogroup is reported to have elevated frequency in some complex diseases. To verify if centenarians clustered in a particular lineage within J we have sequenced the D-loop region from 18 centenarians and 18 younger controls, previously characterized to be J. Then the entire mtDNA molecule was sequenced in a sub-sample of nine centenarians to find possible functional mutations associated with haplogroup J in successful aging. No clustering of the J haplogroup mtDNA from centenarians was observed. In addition, most of the mutations found are known as disease-associated mutations. The general picture that emerges from the study is that the J haplogroup of centenarians is surprisingly similar to that found in complex diseases, as well as in Leber Hereditary Optic Neuropathy. This finding implies that the same mutations could predispose to disease or longevity, probably according to individual-specific genetic backgrounds and stochastic events. This data reveals another paradox of centenarians and confirms the complexity of the longevity trait." @default.
• W2007678016 created "2016-06-24" @default.
• W2007678016 creator A5002433949 @default.
• W2007678016 creator A5021440275 @default.
• W2007678016 creator A5025941399 @default.
• W2007678016 creator A5030785284 @default.
• W2007678016 creator A5043968818 @default.
• W2007678016 creator A5051737410 @default.
• W2007678016 creator A5056841080 @default.
• W2007678016 creator A5078302741 @default.
• W2007678016 creator A5089029390 @default.
• W2007678016 date "2001-09-01" @default.
• W2007678016 modified "2023-10-18" @default.
• W2007678016 title "Paradoxes in longevity: sequence analysis of mtDNA haplogroup J in centenarians" @default.
• W2007678016 cites W1546375972 @default.
• W2007678016 cites W154952985 @default.
• W2007678016 cites W1586907427 @default.
• W2007678016 cites W1834060250 @default.
• W2007678016 cites W1879890282 @default.
• W2007678016 cites W1917926680 @default.
• W2007678016 cites W196029104 @default.
• W2007678016 cites W1971920837 @default.
• W2007678016 cites W1974109692 @default.
• W2007678016 cites W1974472861 @default.
• W2007678016 cites W1978938612 @default.
• W2007678016 cites W1979970299 @default.
• W2007678016 cites W1986314128 @default.
• W2007678016 cites W1986598388 @default.
• W2007678016 cites W1994496497 @default.
• W2007678016 cites W2001702206 @default.
• W2007678016 cites W2005758857 @default.
• W2007678016 cites W2008230512 @default.
• W2007678016 cites W2017035597 @default.
• W2007678016 cites W2017347785 @default.
• W2007678016 cites W2020124142 @default.
• W2007678016 cites W2044494908 @default.
• W2007678016 cites W2058178327 @default.
• W2007678016 cites W2086005166 @default.
• W2007678016 cites W2092170571 @default.
• W2007678016 cites W2093682552 @default.
• W2007678016 cites W2104591129 @default.
• W2007678016 cites W2105532685 @default.
• W2007678016 cites W2109291482 @default.
• W2007678016 cites W2111037990 @default.
• W2007678016 cites W2113350679 @default.
• W2007678016 cites W2128951266 @default.
• W2007678016 cites W2132726974 @default.
• W2007678016 cites W2139699261 @default.
• W2007678016 cites W2157250831 @default.
• W2007678016 cites W2324698254 @default.
• W2007678016 cites W593457592 @default.
• W2007678016 doi "https://doi.org/10.1038/sj.ejhg.5200703" @default.
• W2007678016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11571560" @default.
• W2007678016 hasPublicationYear "2001" @default.
• W2007678016 type Work @default.
• W2007678016 sameAs 2007678016 @default.
• W2007678016 citedByCount "117" @default.
• W2007678016 countsByYear W20076780162012 @default.
• W2007678016 countsByYear W20076780162013 @default.
• W2007678016 countsByYear W20076780162014 @default.
• W2007678016 countsByYear W20076780162015 @default.
• W2007678016 countsByYear W20076780162016 @default.
• W2007678016 countsByYear W20076780162017 @default.
• W2007678016 countsByYear W20076780162018 @default.
• W2007678016 countsByYear W20076780162019 @default.
• W2007678016 countsByYear W20076780162020 @default.
• W2007678016 countsByYear W20076780162021 @default.
• W2007678016 countsByYear W20076780162022 @default.
• W2007678016 crossrefType "journal-article" @default.
• W2007678016 hasAuthorship W2007678016A5002433949 @default.
• W2007678016 hasAuthorship W2007678016A5021440275 @default.
• W2007678016 hasAuthorship W2007678016A5025941399 @default.
• W2007678016 hasAuthorship W2007678016A5030785284 @default.
• W2007678016 hasAuthorship W2007678016A5043968818 @default.
• W2007678016 hasAuthorship W2007678016A5051737410 @default.
• W2007678016 hasAuthorship W2007678016A5056841080 @default.
• W2007678016 hasAuthorship W2007678016A5078302741 @default.
• W2007678016 hasAuthorship W2007678016A5089029390 @default.
• W2007678016 hasBestOaLocation W20076780161 @default.
• W2007678016 hasConcept C104317684 @default.
• W2007678016 hasConcept C180754005 @default.
• W2007678016 hasConcept C197754878 @default.
• W2007678016 hasConcept C201526758 @default.
• W2007678016 hasConcept C24586158 @default.
• W2007678016 hasConcept C2776759703 @default.
• W2007678016 hasConcept C2776817793 @default.
• W2007678016 hasConcept C54355233 @default.
• W2007678016 hasConcept C78450430 @default.
• W2007678016 hasConcept C78458016 @default.
• W2007678016 hasConcept C86803240 @default.
• W2007678016 hasConceptScore W2007678016C104317684 @default.
• W2007678016 hasConceptScore W2007678016C180754005 @default.
• W2007678016 hasConceptScore W2007678016C197754878 @default.
• W2007678016 hasConceptScore W2007678016C201526758 @default.
• W2007678016 hasConceptScore W2007678016C24586158 @default.
• W2007678016 hasConceptScore W2007678016C2776759703 @default.
• W2007678016 hasConceptScore W2007678016C2776817793 @default.
• W2007678016 hasConceptScore W2007678016C54355233 @default.

• next