FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007681284> ?p ?o ?g. }

• W2007681284 endingPage "483" @default.
• W2007681284 startingPage "479" @default.
• W2007681284 abstract "Glioblastoma multiforme is a lethal neoplasm refractory to radiochemotherapy. Although glioma cells undergo apoptosis when exposed to the death ligand, CD95 (Fas/APO-1) ligand, the therapeutic use of CD95L is considered impossible because of lethal side effects. Here, we report that the locoregional application of Apo2 ligand (Apo2L) exerts strong antitumor activity on preestablished intracranially growing human U87MG glioma xenografts in athymic mice. Two repetitive intratumoral injections of 2 microg Apo2L resulted in long-term survival of mice (>100 days), whereas the median survival of mock-treated mice was 36 days. The assessment of tumor volumes at 21 and 35 days after inoculation showed complete eradication of glioma xenografts in Apo2L-treated mice. Histology and TUNEL assay confirmed the induction of apoptosis by Apo2L in glioma cells in vivo. Importantly, the intracerebral injection of Apo2L does not result in acute or delayed neurotoxicity. We propose that a phase 1 trial of intralesional Apo2L therapy for human glioblastoma multiforme is warranted." @default.
• W2007681284 created "2016-06-24" @default.
• W2007681284 creator A5016418059 @default.
• W2007681284 creator A5017177249 @default.
• W2007681284 creator A5025661233 @default.
• W2007681284 creator A5028133447 @default.
• W2007681284 creator A5050072898 @default.
• W2007681284 creator A5079350808 @default.
• W2007681284 creator A5080392503 @default.
• W2007681284 creator A5085976946 @default.
• W2007681284 date "1999-11-01" @default.
• W2007681284 modified "2023-09-27" @default.
• W2007681284 title "Locoregional Apo2L/TRAIL Eradicates Intracranial Human Malignant Glioma Xenografts in Athymic Mice in the Absence of Neurotoxicity" @default.
• W2007681284 cites W1484817497 @default.
• W2007681284 cites W1967753443 @default.
• W2007681284 cites W1974733075 @default.
• W2007681284 cites W1982786027 @default.
• W2007681284 cites W2006870031 @default.
• W2007681284 cites W2021286142 @default.
• W2007681284 cites W2025128734 @default.
• W2007681284 cites W2055905844 @default.
• W2007681284 cites W2056217426 @default.
• W2007681284 cites W2067534266 @default.
• W2007681284 cites W2079270800 @default.
• W2007681284 cites W2084505512 @default.
• W2007681284 cites W2088730075 @default.
• W2007681284 cites W2089476060 @default.
• W2007681284 cites W2092196409 @default.
• W2007681284 cites W2101657738 @default.
• W2007681284 cites W2106284224 @default.
• W2007681284 cites W2113505777 @default.
• W2007681284 cites W2124598613 @default.
• W2007681284 cites W2130988210 @default.
• W2007681284 cites W2144219976 @default.
• W2007681284 cites W2166487006 @default.
• W2007681284 doi "https://doi.org/10.1006/bbrc.1999.1693" @default.
• W2007681284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10558893" @default.
• W2007681284 hasPublicationYear "1999" @default.
• W2007681284 type Work @default.
• W2007681284 sameAs 2007681284 @default.
• W2007681284 citedByCount "204" @default.
• W2007681284 countsByYear W20076812842012 @default.
• W2007681284 countsByYear W20076812842013 @default.
• W2007681284 countsByYear W20076812842014 @default.
• W2007681284 countsByYear W20076812842015 @default.
• W2007681284 countsByYear W20076812842016 @default.
• W2007681284 countsByYear W20076812842017 @default.
• W2007681284 countsByYear W20076812842018 @default.
• W2007681284 countsByYear W20076812842019 @default.
• W2007681284 countsByYear W20076812842020 @default.
• W2007681284 countsByYear W20076812842021 @default.
• W2007681284 countsByYear W20076812842022 @default.
• W2007681284 countsByYear W20076812842023 @default.
• W2007681284 crossrefType "journal-article" @default.
• W2007681284 hasAuthorship W2007681284A5016418059 @default.
• W2007681284 hasAuthorship W2007681284A5017177249 @default.
• W2007681284 hasAuthorship W2007681284A5025661233 @default.
• W2007681284 hasAuthorship W2007681284A5028133447 @default.
• W2007681284 hasAuthorship W2007681284A5050072898 @default.
• W2007681284 hasAuthorship W2007681284A5079350808 @default.
• W2007681284 hasAuthorship W2007681284A5080392503 @default.
• W2007681284 hasAuthorship W2007681284A5085976946 @default.
• W2007681284 hasConcept C126322002 @default.
• W2007681284 hasConcept C142724271 @default.
• W2007681284 hasConcept C150903083 @default.
• W2007681284 hasConcept C190283241 @default.
• W2007681284 hasConcept C196795494 @default.
• W2007681284 hasConcept C204232928 @default.
• W2007681284 hasConcept C207001950 @default.
• W2007681284 hasConcept C2778227246 @default.
• W2007681284 hasConcept C2779491297 @default.
• W2007681284 hasConcept C29730261 @default.
• W2007681284 hasConcept C31573885 @default.
• W2007681284 hasConcept C502942594 @default.
• W2007681284 hasConcept C55493867 @default.
• W2007681284 hasConcept C66008609 @default.
• W2007681284 hasConcept C71924100 @default.
• W2007681284 hasConcept C86803240 @default.
• W2007681284 hasConceptScore W2007681284C126322002 @default.
• W2007681284 hasConceptScore W2007681284C142724271 @default.
• W2007681284 hasConceptScore W2007681284C150903083 @default.
• W2007681284 hasConceptScore W2007681284C190283241 @default.
• W2007681284 hasConceptScore W2007681284C196795494 @default.
• W2007681284 hasConceptScore W2007681284C204232928 @default.
• W2007681284 hasConceptScore W2007681284C207001950 @default.
• W2007681284 hasConceptScore W2007681284C2778227246 @default.
• W2007681284 hasConceptScore W2007681284C2779491297 @default.
• W2007681284 hasConceptScore W2007681284C29730261 @default.
• W2007681284 hasConceptScore W2007681284C31573885 @default.
• W2007681284 hasConceptScore W2007681284C502942594 @default.
• W2007681284 hasConceptScore W2007681284C55493867 @default.
• W2007681284 hasConceptScore W2007681284C66008609 @default.
• W2007681284 hasConceptScore W2007681284C71924100 @default.
• W2007681284 hasConceptScore W2007681284C86803240 @default.
• W2007681284 hasIssue "2" @default.
• W2007681284 hasLocation W20076812841 @default.
• W2007681284 hasLocation W20076812842 @default.
• W2007681284 hasOpenAccess W2007681284 @default.

• next