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- W2007682888 abstract "The production of anti-tetanus toxoid (TT) antibody and anti-anti-TT (auto-anti-Id) antibody has been measured in three young and three old persons. Both antibodies were measured using ELISA. We found that: (i) the anti-TT response of old subjects was lower than that of young subjects, (ii) serum auto-anti-Id antibody concentration was higher in old compared with young humans before boosting with TT, and (iii) anti-TT antibodies from different humans shared Id cross-reactivity when tested with a rabbit anti-Id antibody. Thus, the serum anti-TT antibody response to boosting was inversely correlated with the serum level of auto-anti-Id. This conclusion is consistent with the view that the higher level of auto-anti-antibody in older subjects contributes to their impaired antibody response to TT." @default.
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- W2007682888 date "1993-04-01" @default.
- W2007682888 modified "2023-10-13" @default.
- W2007682888 title "Lower antibody response to tetanus toxoid associated with higher auto-anti-idiotypic antibody in old compared with young humans" @default.
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- W2007682888 doi "https://doi.org/10.1111/j.1365-2249.1993.tb05965.x" @default.
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