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- W2007683103 abstract "The detection limit of a fiber-optic microsensor array was investigated for simultaneous detection of multiple DNA sequences. A random array composed of oligonucleotide-functionalized 3.1-microm-diameter microspheres on the distal face of a 500-microm etched imaging fiber was monitored for binding to fluorescently labeled complementary DNA sequences. Inherent sensor redundancy in the microarray allows the use of multiple microspheres to increase the signal-to-noise ratio, further enhancing the detection capabilities. Specific hybridization was observed for each of three sequences in an array yielding a detection limit of 10(-21) mol (approximately 600 DNA molecules)." @default.
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- W2007683103 date "2002-03-08" @default.
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- W2007683103 title "High-Density Fiber-Optic Genosensor Microsphere Array Capable of Zeptomole Detection Limits" @default.
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- W2007683103 doi "https://doi.org/10.1021/ac0156619" @default.
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