Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007683258> ?p ?o ?g. }
- W2007683258 endingPage "57" @default.
- W2007683258 startingPage "51" @default.
- W2007683258 abstract "Summary. Interferon‐α and nucleoside analogues are available for the treatment of chronic hepatitis B virus (HBV) infection but do not lead to a satisfactory result. New findings about the immunological control of HBV during acute infection suggest the pivotal role of T‐cell mediated immune responses. Several preclinical and clinical trials were undertaken to explore the possibility of stimulating specific immune responses in chronically infected animals and patients by vaccination. However, vaccination with commercially available HBV vaccines in patients and immunization in woodchucks with core or surface proteins of woodchuck hepatitis virus (WHV) did not result in effective control of HBV and WHV infection, suggesting that new formulations of therapeutic vaccines are needed. Some new approaches combining antiviral treatments with nucleoside analogues, DNA vaccines and protein vaccines were tested in the woodchuck model. It could be shown that therapeutic vaccinations are able to stimulate specific B‐ and T‐cell responses and to achieve transient suppression of viral replication. These results suggest the great potential of therapeutic vaccination in combination with antivirals to reach an effective and sustained control of HBV infection." @default.
- W2007683258 created "2016-06-24" @default.
- W2007683258 creator A5003377806 @default.
- W2007683258 creator A5063783789 @default.
- W2007683258 creator A5077983312 @default.
- W2007683258 creator A5082162455 @default.
- W2007683258 date "2007-10-22" @default.
- W2007683258 modified "2023-09-27" @default.
- W2007683258 title "Therapeutic vaccination in chronic hepatitis B: preclinical studies in the woodchuck model" @default.
- W2007683258 cites W123332178 @default.
- W2007683258 cites W147819812 @default.
- W2007683258 cites W1498637003 @default.
- W2007683258 cites W1907707905 @default.
- W2007683258 cites W1964520444 @default.
- W2007683258 cites W1967684158 @default.
- W2007683258 cites W1976725250 @default.
- W2007683258 cites W1977236527 @default.
- W2007683258 cites W1997047331 @default.
- W2007683258 cites W2004375393 @default.
- W2007683258 cites W2006814219 @default.
- W2007683258 cites W2008517556 @default.
- W2007683258 cites W2010912163 @default.
- W2007683258 cites W2011361976 @default.
- W2007683258 cites W2017312443 @default.
- W2007683258 cites W2021990934 @default.
- W2007683258 cites W2022337477 @default.
- W2007683258 cites W2042653258 @default.
- W2007683258 cites W2044261391 @default.
- W2007683258 cites W2050227969 @default.
- W2007683258 cites W2054881297 @default.
- W2007683258 cites W2061505027 @default.
- W2007683258 cites W2068005505 @default.
- W2007683258 cites W2069030584 @default.
- W2007683258 cites W2071267501 @default.
- W2007683258 cites W2079096953 @default.
- W2007683258 cites W2090711530 @default.
- W2007683258 cites W2091054183 @default.
- W2007683258 cites W2091603777 @default.
- W2007683258 cites W2093181596 @default.
- W2007683258 cites W2096094255 @default.
- W2007683258 cites W2097363365 @default.
- W2007683258 cites W2098459535 @default.
- W2007683258 cites W2099864608 @default.
- W2007683258 cites W2101032357 @default.
- W2007683258 cites W2111629931 @default.
- W2007683258 cites W2115150071 @default.
- W2007683258 cites W2116118057 @default.
- W2007683258 cites W2117835382 @default.
- W2007683258 cites W2120402476 @default.
- W2007683258 cites W2123520051 @default.
- W2007683258 cites W2127889847 @default.
- W2007683258 cites W2133908848 @default.
- W2007683258 cites W2149101045 @default.
- W2007683258 cites W2157098396 @default.
- W2007683258 cites W2164439917 @default.
- W2007683258 cites W2170958001 @default.
- W2007683258 cites W2171278872 @default.
- W2007683258 cites W2401112309 @default.
- W2007683258 cites W1590309550 @default.
- W2007683258 doi "https://doi.org/10.1111/j.1365-2893.2007.00914.x" @default.
- W2007683258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17958643" @default.
- W2007683258 hasPublicationYear "2007" @default.
- W2007683258 type Work @default.
- W2007683258 sameAs 2007683258 @default.
- W2007683258 citedByCount "16" @default.
- W2007683258 countsByYear W20076832582013 @default.
- W2007683258 countsByYear W20076832582015 @default.
- W2007683258 countsByYear W20076832582016 @default.
- W2007683258 countsByYear W20076832582018 @default.
- W2007683258 countsByYear W20076832582019 @default.
- W2007683258 countsByYear W20076832582020 @default.
- W2007683258 countsByYear W20076832582021 @default.
- W2007683258 crossrefType "journal-article" @default.
- W2007683258 hasAuthorship W2007683258A5003377806 @default.
- W2007683258 hasAuthorship W2007683258A5063783789 @default.
- W2007683258 hasAuthorship W2007683258A5077983312 @default.
- W2007683258 hasAuthorship W2007683258A5082162455 @default.
- W2007683258 hasConcept C159047783 @default.
- W2007683258 hasConcept C167508917 @default.
- W2007683258 hasConcept C203014093 @default.
- W2007683258 hasConcept C22070199 @default.
- W2007683258 hasConcept C2522874641 @default.
- W2007683258 hasConcept C2776543447 @default.
- W2007683258 hasConcept C2777333352 @default.
- W2007683258 hasConcept C2777382497 @default.
- W2007683258 hasConcept C2780593183 @default.
- W2007683258 hasConcept C2780617729 @default.
- W2007683258 hasConcept C2780801004 @default.
- W2007683258 hasConcept C2781079990 @default.
- W2007683258 hasConcept C55493867 @default.
- W2007683258 hasConcept C71924100 @default.
- W2007683258 hasConcept C86803240 @default.
- W2007683258 hasConcept C8891405 @default.
- W2007683258 hasConceptScore W2007683258C159047783 @default.
- W2007683258 hasConceptScore W2007683258C167508917 @default.
- W2007683258 hasConceptScore W2007683258C203014093 @default.
- W2007683258 hasConceptScore W2007683258C22070199 @default.
- W2007683258 hasConceptScore W2007683258C2522874641 @default.