FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007684837> ?p ?o ?g. }

• W2007684837 endingPage "290" @default.
• W2007684837 startingPage "281" @default.
• W2007684837 abstract "Sex-specific differences in pulmonary morbidity in humans are well documented. Hyperoxia contributes to lung injury in experimental animals and humans. The mechanisms responsible for sex differences in the susceptibility towards hyperoxic lung injury remain largely unknown. In this investigation, we tested the hypothesis that mice will display sex-specific differences in hyperoxic lung injury. Eight week-old male and female mice (C57BL/6J) were exposed to 72 h of hyperoxia (FiO2 > 0.95). After exposure to hyperoxia, lung injury, levels of 8-iso-prostaglandin F2 alpha (8-iso-PGF 2α) (LC–MS/MS), apoptosis (TUNEL) and inflammatory markers (suspension bead array) were determined. Cytochrome P450 (CYP)1A expression in the lung was assessed using immunohistochemistry and western blotting. After exposure to hyperoxia, males showed greater lung injury, neutrophil infiltration and apoptosis, compared to air-breathing controls than females. Pulmonary 8-iso-PGF 2α levels were higher in males than females after hyperoxia exposure. Sexually dimorphic increases in levels of IL-6 (F > M) and VEGF (M > F) in the lungs were also observed. CYP1A1 expression in the lung was higher in female mice compared to males under hyperoxic conditions. Overall, our results support the hypothesis that male mice are more susceptible than females to hyperoxic lung injury and that differences in inflammatory and oxidative stress markers contribute to these sex-specific dimorphic effects. In conclusion, this paper describes the establishment of an animal model that shows sex differences in hyperoxic lung injury in a temporal manner and thus has important implications for lung diseases mediated by hyperoxia in humans." @default.
• W2007684837 created "2016-06-24" @default.
• W2007684837 creator A5001364718 @default.
• W2007684837 creator A5006081813 @default.
• W2007684837 creator A5040215906 @default.
• W2007684837 creator A5055200480 @default.
• W2007684837 creator A5063079542 @default.
• W2007684837 creator A5085230748 @default.
• W2007684837 date "2013-10-01" @default.
• W2007684837 modified "2023-09-30" @default.
• W2007684837 title "Sex-specific differences in hyperoxic lung injury in mice: Implications for acute and chronic lung disease in humans" @default.
• W2007684837 cites W1509539524 @default.
• W2007684837 cites W1550989404 @default.
• W2007684837 cites W185109916 @default.
• W2007684837 cites W1940416395 @default.
• W2007684837 cites W1973163523 @default.
• W2007684837 cites W1974861627 @default.
• W2007684837 cites W1978894516 @default.
• W2007684837 cites W1981949220 @default.
• W2007684837 cites W1988736324 @default.
• W2007684837 cites W1990819855 @default.
• W2007684837 cites W1991640279 @default.
• W2007684837 cites W1994885986 @default.
• W2007684837 cites W1995274086 @default.
• W2007684837 cites W1996621660 @default.
• W2007684837 cites W1998180871 @default.
• W2007684837 cites W2006290704 @default.
• W2007684837 cites W2008254631 @default.
• W2007684837 cites W2011603673 @default.
• W2007684837 cites W2015068829 @default.
• W2007684837 cites W2025685262 @default.
• W2007684837 cites W2031027623 @default.
• W2007684837 cites W2037633953 @default.
• W2007684837 cites W2042701594 @default.
• W2007684837 cites W2048741717 @default.
• W2007684837 cites W2050717509 @default.
• W2007684837 cites W2054112283 @default.
• W2007684837 cites W2061244987 @default.
• W2007684837 cites W2090797106 @default.
• W2007684837 cites W2094559890 @default.
• W2007684837 cites W2096372666 @default.
• W2007684837 cites W2115144902 @default.
• W2007684837 cites W2119615201 @default.
• W2007684837 cites W2127045955 @default.
• W2007684837 cites W2136172209 @default.
• W2007684837 cites W2147257512 @default.
• W2007684837 cites W2159396934 @default.
• W2007684837 cites W2164872331 @default.
• W2007684837 cites W2169296425 @default.
• W2007684837 cites W2409369869 @default.
• W2007684837 cites W4247849359 @default.
• W2007684837 doi "https://doi.org/10.1016/j.taap.2013.06.007" @default.
• W2007684837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4201582" @default.
• W2007684837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23792423" @default.
• W2007684837 hasPublicationYear "2013" @default.
• W2007684837 type Work @default.
• W2007684837 sameAs 2007684837 @default.
• W2007684837 citedByCount "40" @default.
• W2007684837 countsByYear W20076848372013 @default.
• W2007684837 countsByYear W20076848372014 @default.
• W2007684837 countsByYear W20076848372015 @default.
• W2007684837 countsByYear W20076848372016 @default.
• W2007684837 countsByYear W20076848372017 @default.
• W2007684837 countsByYear W20076848372018 @default.
• W2007684837 countsByYear W20076848372020 @default.
• W2007684837 countsByYear W20076848372021 @default.
• W2007684837 countsByYear W20076848372022 @default.
• W2007684837 countsByYear W20076848372023 @default.
• W2007684837 crossrefType "journal-article" @default.
• W2007684837 hasAuthorship W2007684837A5001364718 @default.
• W2007684837 hasAuthorship W2007684837A5006081813 @default.
• W2007684837 hasAuthorship W2007684837A5040215906 @default.
• W2007684837 hasAuthorship W2007684837A5055200480 @default.
• W2007684837 hasAuthorship W2007684837A5063079542 @default.
• W2007684837 hasAuthorship W2007684837A5085230748 @default.
• W2007684837 hasBestOaLocation W20076848372 @default.
• W2007684837 hasConcept C105083479 @default.
• W2007684837 hasConcept C126322002 @default.
• W2007684837 hasConcept C134018914 @default.
• W2007684837 hasConcept C142724271 @default.
• W2007684837 hasConcept C16685009 @default.
• W2007684837 hasConcept C196795494 @default.
• W2007684837 hasConcept C204232928 @default.
• W2007684837 hasConcept C2776151105 @default.
• W2007684837 hasConcept C2776178081 @default.
• W2007684837 hasConcept C2777714996 @default.
• W2007684837 hasConcept C2780672939 @default.
• W2007684837 hasConcept C42407357 @default.
• W2007684837 hasConcept C71924100 @default.
• W2007684837 hasConcept C86803240 @default.
• W2007684837 hasConceptScore W2007684837C105083479 @default.
• W2007684837 hasConceptScore W2007684837C126322002 @default.
• W2007684837 hasConceptScore W2007684837C134018914 @default.
• W2007684837 hasConceptScore W2007684837C142724271 @default.
• W2007684837 hasConceptScore W2007684837C16685009 @default.
• W2007684837 hasConceptScore W2007684837C196795494 @default.
• W2007684837 hasConceptScore W2007684837C204232928 @default.
• W2007684837 hasConceptScore W2007684837C2776151105 @default.

• next