Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007684916> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2007684916 endingPage "48" @default.
- W2007684916 startingPage "41" @default.
- W2007684916 abstract "Low molar ratios of heparin inhibited in vitro assembly of bovine brain microtubule proteins and disassembled preformed microtubules. Addition of purified microtubule-associated proteins counteracted the assembly inhibition by heparin. Our results suggest that the polyanion heparin affects microtubule assembly by binding to the microtubule-associated proteins. This complex can not support nucleation or stabilize the microtubule structure although it still can associate with the tubulin polymer. In the presence of heparin, the critical concentration needed for microtubule assembly was increased. Furthermore, the absolute assembly difference induced by heparin, the delta A350, was only dependent on the concentration and the molecular weight of heparin, not of the total microtubule protein concentration, or the addition of microtubule-associated proteins. Commercial, standard heparin (Mr 6000-25 000) had an I50 of about 0.1/tubulin dimer. The heparin fraction(s) with a high molecular weight had a stronger effect than those with lower molecular weight. Substoichiometric amounts of taxol completely relieved the inhibition of assembly by heparin, although aberrant forms were present. These microtubules had a reduced amount of coassembled microtubule-associated proteins, and furthermore contained heparin." @default.
- W2007684916 created "2016-06-24" @default.
- W2007684916 creator A5006508402 @default.
- W2007684916 creator A5010385613 @default.
- W2007684916 creator A5048872016 @default.
- W2007684916 creator A5077491187 @default.
- W2007684916 date "1984-11-06" @default.
- W2007684916 modified "2023-09-26" @default.
- W2007684916 title "Molecular weight dependency of heparin inhibition of microtubule assembly in vitro" @default.
- W2007684916 cites W1517218704 @default.
- W2007684916 cites W1527756075 @default.
- W2007684916 cites W1606423922 @default.
- W2007684916 cites W1823264052 @default.
- W2007684916 cites W1999929175 @default.
- W2007684916 cites W2016631362 @default.
- W2007684916 cites W2034022561 @default.
- W2007684916 cites W2051947884 @default.
- W2007684916 cites W2059453596 @default.
- W2007684916 cites W2060300831 @default.
- W2007684916 cites W2061596496 @default.
- W2007684916 cites W2063506992 @default.
- W2007684916 cites W2064689605 @default.
- W2007684916 cites W2076038286 @default.
- W2007684916 cites W2076543654 @default.
- W2007684916 cites W2077134367 @default.
- W2007684916 cites W2087188810 @default.
- W2007684916 cites W2091341876 @default.
- W2007684916 cites W2093480892 @default.
- W2007684916 cites W2128635872 @default.
- W2007684916 cites W2145555831 @default.
- W2007684916 cites W2225097484 @default.
- W2007684916 cites W3114713417 @default.
- W2007684916 doi "https://doi.org/10.1016/0304-4165(84)90031-x" @default.
- W2007684916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6148967" @default.
- W2007684916 hasPublicationYear "1984" @default.
- W2007684916 type Work @default.
- W2007684916 sameAs 2007684916 @default.
- W2007684916 citedByCount "14" @default.
- W2007684916 crossrefType "journal-article" @default.
- W2007684916 hasAuthorship W2007684916A5006508402 @default.
- W2007684916 hasAuthorship W2007684916A5010385613 @default.
- W2007684916 hasAuthorship W2007684916A5048872016 @default.
- W2007684916 hasAuthorship W2007684916A5077491187 @default.
- W2007684916 hasConcept C10447061 @default.
- W2007684916 hasConcept C12554922 @default.
- W2007684916 hasConcept C1491633281 @default.
- W2007684916 hasConcept C178790620 @default.
- W2007684916 hasConcept C185592680 @default.
- W2007684916 hasConcept C202751555 @default.
- W2007684916 hasConcept C20418707 @default.
- W2007684916 hasConcept C2777557582 @default.
- W2007684916 hasConcept C2779546866 @default.
- W2007684916 hasConcept C29537977 @default.
- W2007684916 hasConcept C55493867 @default.
- W2007684916 hasConcept C84425145 @default.
- W2007684916 hasConcept C86803240 @default.
- W2007684916 hasConcept C94921385 @default.
- W2007684916 hasConcept C95444343 @default.
- W2007684916 hasConceptScore W2007684916C10447061 @default.
- W2007684916 hasConceptScore W2007684916C12554922 @default.
- W2007684916 hasConceptScore W2007684916C1491633281 @default.
- W2007684916 hasConceptScore W2007684916C178790620 @default.
- W2007684916 hasConceptScore W2007684916C185592680 @default.
- W2007684916 hasConceptScore W2007684916C202751555 @default.
- W2007684916 hasConceptScore W2007684916C20418707 @default.
- W2007684916 hasConceptScore W2007684916C2777557582 @default.
- W2007684916 hasConceptScore W2007684916C2779546866 @default.
- W2007684916 hasConceptScore W2007684916C29537977 @default.
- W2007684916 hasConceptScore W2007684916C55493867 @default.
- W2007684916 hasConceptScore W2007684916C84425145 @default.
- W2007684916 hasConceptScore W2007684916C86803240 @default.
- W2007684916 hasConceptScore W2007684916C94921385 @default.
- W2007684916 hasConceptScore W2007684916C95444343 @default.
- W2007684916 hasIssue "1" @default.
- W2007684916 hasLocation W20076849161 @default.
- W2007684916 hasLocation W20076849162 @default.
- W2007684916 hasOpenAccess W2007684916 @default.
- W2007684916 hasPrimaryLocation W20076849161 @default.
- W2007684916 hasRelatedWork W1970425102 @default.
- W2007684916 hasRelatedWork W1999762336 @default.
- W2007684916 hasRelatedWork W2041142511 @default.
- W2007684916 hasRelatedWork W2060004518 @default.
- W2007684916 hasRelatedWork W2079454179 @default.
- W2007684916 hasRelatedWork W2084823034 @default.
- W2007684916 hasRelatedWork W2414947116 @default.
- W2007684916 hasRelatedWork W2949213253 @default.
- W2007684916 hasRelatedWork W4220756135 @default.
- W2007684916 hasRelatedWork W4295047915 @default.
- W2007684916 hasVolume "802" @default.
- W2007684916 isParatext "false" @default.
- W2007684916 isRetracted "false" @default.
- W2007684916 magId "2007684916" @default.
- W2007684916 workType "article" @default.