FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007686912> ?p ?o ?g. }

• W2007686912 abstract "Previous investigations indicate that diminished functional expression of voltage-dependent K+ (KV) channels impairs control of coronary blood flow in obesity/metabolic syndrome. The goal of this investigation was to test the hypothesis that KV channels are electromechanically coupled to CaV1.2 channels and that coronary microvascular dysfunction in obesity is related to subsequent increases in CaV1.2 channel activity. Initial studies revealed that inhibition of KV channels with 4-aminopyridine (4AP, 0.3 mM) increased intracellular [Ca2+], contracted isolated coronary arterioles and decreased coronary reactive hyperemia. These effects were reversed by blockade of CaV1.2 channels. Further studies in chronically instrumented Ossabaw swine showed that inhibition of CaV1.2 channels with nifedipine (10 μg/kg, iv) had no effect on coronary blood flow at rest or during exercise in lean swine. However, inhibition of CaV1.2 channels significantly increased coronary blood flow, conductance, and the balance between coronary flow and metabolism in obese swine (P < 0.05). These changes were associated with a ~50 % increase in inward CaV1.2 current and elevations in expression of the pore-forming subunit (α1c) of CaV1.2 channels in coronary smooth muscle cells from obese swine. Taken together, these findings indicate that electromechanical coupling between KV and CaV1.2 channels is involved in the regulation of coronary vasomotor tone and that increases in CaV1.2 channel activity contribute to coronary microvascular dysfunction in the setting of obesity." @default.
• W2007686912 created "2016-06-24" @default.
• W2007686912 creator A5008999021 @default.
• W2007686912 creator A5013891757 @default.
• W2007686912 creator A5038570981 @default.
• W2007686912 creator A5042540373 @default.
• W2007686912 creator A5049983178 @default.
• W2007686912 creator A5059753019 @default.
• W2007686912 creator A5083744223 @default.
• W2007686912 creator A5086320275 @default.
• W2007686912 creator A5089665704 @default.
• W2007686912 creator A5091880798 @default.
• W2007686912 date "2013-07-16" @default.
• W2007686912 modified "2023-09-26" @default.
• W2007686912 title "Contribution of electromechanical coupling between KV and CaV1.2 channels to coronary dysfunction in obesity" @default.
• W2007686912 cites W134363133 @default.
• W2007686912 cites W1664326609 @default.
• W2007686912 cites W1884656506 @default.
• W2007686912 cites W1971256871 @default.
• W2007686912 cites W1982278691 @default.
• W2007686912 cites W1987284716 @default.
• W2007686912 cites W1989287742 @default.
• W2007686912 cites W1992822412 @default.
• W2007686912 cites W1993200959 @default.
• W2007686912 cites W1996484675 @default.
• W2007686912 cites W2015281632 @default.
• W2007686912 cites W2018682013 @default.
• W2007686912 cites W2022120529 @default.
• W2007686912 cites W2023385878 @default.
• W2007686912 cites W2026991049 @default.
• W2007686912 cites W2046328525 @default.
• W2007686912 cites W2047306983 @default.
• W2007686912 cites W2051574006 @default.
• W2007686912 cites W2054041922 @default.
• W2007686912 cites W2059143419 @default.
• W2007686912 cites W2060282271 @default.
• W2007686912 cites W2064853201 @default.
• W2007686912 cites W2067140471 @default.
• W2007686912 cites W2075182946 @default.
• W2007686912 cites W2075748538 @default.
• W2007686912 cites W2087029192 @default.
• W2007686912 cites W2087328197 @default.
• W2007686912 cites W2091965408 @default.
• W2007686912 cites W2097185673 @default.
• W2007686912 cites W2112696231 @default.
• W2007686912 cites W2114333917 @default.
• W2007686912 cites W2117119810 @default.
• W2007686912 cites W2117220835 @default.
• W2007686912 cites W2121000859 @default.
• W2007686912 cites W2122789412 @default.
• W2007686912 cites W2128700274 @default.
• W2007686912 cites W2137884233 @default.
• W2007686912 cites W2138001030 @default.
• W2007686912 cites W2141207242 @default.
• W2007686912 cites W2157385446 @default.
• W2007686912 cites W2158282742 @default.
• W2007686912 cites W2160358510 @default.
• W2007686912 cites W2160931357 @default.
• W2007686912 cites W2161295912 @default.
• W2007686912 cites W2168530906 @default.
• W2007686912 doi "https://doi.org/10.1007/s00395-013-0370-0" @default.
• W2007686912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3818702" @default.
• W2007686912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23856709" @default.
• W2007686912 hasPublicationYear "2013" @default.
• W2007686912 type Work @default.
• W2007686912 sameAs 2007686912 @default.
• W2007686912 citedByCount "20" @default.
• W2007686912 countsByYear W20076869122014 @default.
• W2007686912 countsByYear W20076869122016 @default.
• W2007686912 countsByYear W20076869122017 @default.
• W2007686912 countsByYear W20076869122019 @default.
• W2007686912 countsByYear W20076869122020 @default.
• W2007686912 countsByYear W20076869122021 @default.
• W2007686912 countsByYear W20076869122022 @default.
• W2007686912 crossrefType "journal-article" @default.
• W2007686912 hasAuthorship W2007686912A5008999021 @default.
• W2007686912 hasAuthorship W2007686912A5013891757 @default.
• W2007686912 hasAuthorship W2007686912A5038570981 @default.
• W2007686912 hasAuthorship W2007686912A5042540373 @default.
• W2007686912 hasAuthorship W2007686912A5049983178 @default.
• W2007686912 hasAuthorship W2007686912A5059753019 @default.
• W2007686912 hasAuthorship W2007686912A5083744223 @default.
• W2007686912 hasAuthorship W2007686912A5086320275 @default.
• W2007686912 hasAuthorship W2007686912A5089665704 @default.
• W2007686912 hasAuthorship W2007686912A5091880798 @default.
• W2007686912 hasBestOaLocation W20076869122 @default.
• W2007686912 hasConcept C126322002 @default.
• W2007686912 hasConcept C134018914 @default.
• W2007686912 hasConcept C158846371 @default.
• W2007686912 hasConcept C164705383 @default.
• W2007686912 hasConcept C18699975 @default.
• W2007686912 hasConcept C2776157398 @default.
• W2007686912 hasConcept C2776972302 @default.
• W2007686912 hasConcept C2779066535 @default.
• W2007686912 hasConcept C3019128504 @default.
• W2007686912 hasConcept C519063684 @default.
• W2007686912 hasConcept C71924100 @default.
• W2007686912 hasConceptScore W2007686912C126322002 @default.
• W2007686912 hasConceptScore W2007686912C134018914 @default.
• W2007686912 hasConceptScore W2007686912C158846371 @default.

• next