FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007688223> ?p ?o ?g. }

• W2007688223 endingPage "156" @default.
• W2007688223 startingPage "143" @default.
• W2007688223 abstract "Mitochondrial inner membrane contains a latent pore (PTP) that when opened uncouples mitochondrial energy transduction and allows rapid equilibration of low-molecular-weight solutes between the matrix and exterior. Based on sensitivity of the PTP to well-known free radical scavenger butylhydroxytoluene (BHT), it has been proposed that increased steady-state level of oxygen radicals, and subsequent radical attack of proteins and lipids, is a central event in activation of this pore (Novgorodovet al., J. Bioenerg. Biomembr.19, 191–202, 1987; Carbonera and Azzone,Biochim. Biophys. Acta943, 245–255, 1988). Present studies revealed that DBT, a derivative of BHT devoid of radical scavenging activity, exerts an analogous effect on the permeability of the inner membrane. Inhibition of the Ca2+-induced PTP opening is essentially complete at dose range of 50–60 nmol/mg protein with IC50values of about 32 and 23 nmol/mg protein for DBT and BHT, respectively. Electron microscopy and osmotic experiments utilizing polyethylene glycols with different Stokes radii showed that the apparent lack of inhibition seen at high concentrations of these compounds results from cyclosporin A- and Ca2+-insensitive pore formation in the inner membrane. Experiments employing antioxidants with similar structure but dissimilar hydrophobicity provided evidence for localization of the antioxidant binding sites within the hydrophobic zone of the inner membrane or in the matrix space. The data obtained do not refute the notion that oxygen radicals modulate the PTP, but rather indicate that BHT operates independently of its free radical scavenging activity. Overall, the sensitivity to BHT and other antioxidants is not always a reliable criterion for the involvement of free radical reactions in the processes under study." @default.
• W2007688223 created "2016-06-24" @default.
• W2007688223 creator A5009637284 @default.
• W2007688223 creator A5024617546 @default.
• W2007688223 creator A5036479060 @default.
• W2007688223 creator A5063058878 @default.
• W2007688223 creator A5085128345 @default.
• W2007688223 date "1997-06-01" @default.
• W2007688223 modified "2023-09-26" @default.
• W2007688223 title "Effect of Butylhydroxytoluene and Related Compounds on Permeability of the Inner Mitochondrial Membrane" @default.
• W2007688223 cites W1480051253 @default.
• W2007688223 cites W1482769266 @default.
• W2007688223 cites W1496281435 @default.
• W2007688223 cites W1505511924 @default.
• W2007688223 cites W1506478670 @default.
• W2007688223 cites W1507410890 @default.
• W2007688223 cites W1526513913 @default.
• W2007688223 cites W1544314658 @default.
• W2007688223 cites W1548077438 @default.
• W2007688223 cites W1553151511 @default.
• W2007688223 cites W1567313097 @default.
• W2007688223 cites W1575793691 @default.
• W2007688223 cites W1578941035 @default.
• W2007688223 cites W1583495578 @default.
• W2007688223 cites W1597814524 @default.
• W2007688223 cites W1599255220 @default.
• W2007688223 cites W1599706474 @default.
• W2007688223 cites W1622285696 @default.
• W2007688223 cites W1742052950 @default.
• W2007688223 cites W1924692271 @default.
• W2007688223 cites W1970178221 @default.
• W2007688223 cites W1971068325 @default.
• W2007688223 cites W1976169837 @default.
• W2007688223 cites W1977299427 @default.
• W2007688223 cites W1983721382 @default.
• W2007688223 cites W1989264681 @default.
• W2007688223 cites W1989911931 @default.
• W2007688223 cites W1991875900 @default.
• W2007688223 cites W1998545626 @default.
• W2007688223 cites W1999129403 @default.
• W2007688223 cites W2005094104 @default.
• W2007688223 cites W2006720733 @default.
• W2007688223 cites W2009461852 @default.
• W2007688223 cites W2011297923 @default.
• W2007688223 cites W2022500726 @default.
• W2007688223 cites W2027055758 @default.
• W2007688223 cites W2027441704 @default.
• W2007688223 cites W2027874650 @default.
• W2007688223 cites W2028118682 @default.
• W2007688223 cites W2033852962 @default.
• W2007688223 cites W2040048187 @default.
• W2007688223 cites W2040798104 @default.
• W2007688223 cites W2045145264 @default.
• W2007688223 cites W2045737719 @default.
• W2007688223 cites W2048290905 @default.
• W2007688223 cites W2049499236 @default.
• W2007688223 cites W2052406949 @default.
• W2007688223 cites W2054989425 @default.
• W2007688223 cites W2063867331 @default.
• W2007688223 cites W2064347675 @default.
• W2007688223 cites W2067779768 @default.
• W2007688223 cites W2069498907 @default.
• W2007688223 cites W2081758047 @default.
• W2007688223 cites W2085030699 @default.
• W2007688223 cites W2091387921 @default.
• W2007688223 cites W2132826785 @default.
• W2007688223 cites W2152311269 @default.
• W2007688223 cites W2155429394 @default.
• W2007688223 cites W2223149090 @default.
• W2007688223 cites W2255476717 @default.
• W2007688223 cites W2308938068 @default.
• W2007688223 doi "https://doi.org/10.1006/abbi.1997.0113" @default.
• W2007688223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9185623" @default.
• W2007688223 hasPublicationYear "1997" @default.
• W2007688223 type Work @default.
• W2007688223 sameAs 2007688223 @default.
• W2007688223 citedByCount "25" @default.
• W2007688223 crossrefType "journal-article" @default.
• W2007688223 hasAuthorship W2007688223A5009637284 @default.
• W2007688223 hasAuthorship W2007688223A5024617546 @default.
• W2007688223 hasAuthorship W2007688223A5036479060 @default.
• W2007688223 hasAuthorship W2007688223A5063058878 @default.
• W2007688223 hasAuthorship W2007688223A5085128345 @default.
• W2007688223 hasConcept C12554922 @default.
• W2007688223 hasConcept C139066938 @default.
• W2007688223 hasConcept C185592680 @default.
• W2007688223 hasConcept C2778004101 @default.
• W2007688223 hasConcept C28859421 @default.
• W2007688223 hasConcept C41625074 @default.
• W2007688223 hasConcept C55493867 @default.
• W2007688223 hasConcept C65871279 @default.
• W2007688223 hasConcept C75385678 @default.
• W2007688223 hasConcept C86803240 @default.
• W2007688223 hasConceptScore W2007688223C12554922 @default.
• W2007688223 hasConceptScore W2007688223C139066938 @default.
• W2007688223 hasConceptScore W2007688223C185592680 @default.
• W2007688223 hasConceptScore W2007688223C2778004101 @default.
• W2007688223 hasConceptScore W2007688223C28859421 @default.

• next