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- W2007689936 abstract "Abstract Low Density Lipoprotein is a potential drug carrier system in cancer chemotherapy; however, the isolation and handling of the native particle is difficult. In this paper we discuss the incorporation of lipid-soluble antineoplastic agents into microemulsions which act as readily obtainable synthetic protein-free analogues of Low Density Lipoprotein. The addition of the cytotoxic drug to the dried lipids before treatment to form the microemulsion results in the partial incorporation of the drug into the microemulsion particles. Drug incorporation is related to the properties of the cytotoxic used as etoposide would not incorporate whereas approximately 60% of added methotrexate-α-benzyl-γ-cholesteryl diester was incorporated into the microemulsions. The particles formed appear to be stable with only a slight increase in size over the time period studied, and with no leakage of the entrapped drug. The activity of the microemulsion against L1210 murine leukaemia cells has been tested in vitro. In normal media or in media containing lipoprotcin-dcficient serum the partiel s were inactive at the concentrations used. However, in serum-free media the microemulsion exhibited growth inhibitory effects that were approximately 500 times less active than free mcthotrcxatc; this difference in activity would appear to be due to a differential interaction of the cell with the particles which occurs in serum-free media." @default.
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- W2007689936 title "The incorporation of lipid-soluble antineoplastic agents into microemulsions—protein-free analogues of Low Density Lipoprotein" @default.
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- W2007689936 doi "https://doi.org/10.1016/0378-5173(84)90096-6" @default.
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