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- W2007690690 abstract "Matrix rigidity sensing regulates a large variety of cellular processes and has important implications for tissue development and disease. However, how cells probe matrix rigidity, and hence respond to it, remains unclear. Here, we show that rigidity sensing and adaptation emerge naturally from actin cytoskeleton remodelling. We report that cells markedly modify their internal rheology and traction forces in response to substrate stiffness. Our in vitro experiments and theoretical modeling demonstrate a bi-phasic behavior of the actin cytoskeleton, which transitions sharply from fluid on soft substrates to solid on stiffer ones. Furthermore, we find that increasing substrate stiffness correlates with the emergence of orientational order in actin stress fibers, which exhibit an isotropic to nematic transition that we characterize quantitatively in the framework of active matter theory6. This finding implicates mechanisms mediated not only by the activation of local adhesion complexes, as it is usually assumed, but also by a large-scale reinforcement of actin structures under stress. As such, this unanticipated rheological response of the cell represents the mechanical driver of cell shape changes and cell polarity as a function of substrate stiffness." @default.
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- W2007690690 date "2015-01-01" @default.
- W2007690690 modified "2023-09-30" @default.
- W2007690690 title "Adaptative Response of Cell Cytoskeleton Rheology and Ordering Governs Matrix Rigidity Sensing" @default.
- W2007690690 doi "https://doi.org/10.1016/j.bpj.2014.11.040" @default.
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