Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007691849> ?p ?o ?g. }
- W2007691849 endingPage "841" @default.
- W2007691849 startingPage "831" @default.
- W2007691849 abstract "The mechanisms of induction and the site of expression of long-term depression (LTD) at the hippocampal mossy fiber-CA3 synapses are not clear. Here, we show that a brief bath application of insulin induces a novel form of mossy fiber LTD. This insulin-LTD is (1) induced and expressed postsynaptically, (2) entirely independent of synaptic stimulation during insulin application, (3) involving a rise in postsynaptic [Ca(2+)](i) and L-type voltage-activated Ca(2+) channel activation, (4) mechanistically distinct from low-frequency stimulation-induced LTD, (5) dependent on phosphatidylinositol 3-kinase signaling, and (6) associated with a clathrin-mediated endocytotic removal of surface 3-hydroxy-5-methylisoxazole-4-propionic acid receptors from the postsynaptic neurons. Moreover, insulin-LTD is specific to mossy fibers to CA3 pyramidal cell synapses, and is not present at associational commissural synapses. These findings not only support a postsynaptic locus of mossy fiber LTD, but also provide a further link between the AMPA receptor trafficking and the bidirectional expression of long-term synaptic plasticity." @default.
- W2007691849 created "2016-06-24" @default.
- W2007691849 creator A5018506745 @default.
- W2007691849 creator A5031754749 @default.
- W2007691849 creator A5043847188 @default.
- W2007691849 creator A5052365004 @default.
- W2007691849 date "2003-11-01" @default.
- W2007691849 modified "2023-10-10" @default.
- W2007691849 title "Insulin induces a novel form of postsynaptic mossy fiber long-term depression in the hippocampus" @default.
- W2007691849 cites W1507515137 @default.
- W2007691849 cites W1513561540 @default.
- W2007691849 cites W1515214283 @default.
- W2007691849 cites W1573292604 @default.
- W2007691849 cites W1590528461 @default.
- W2007691849 cites W1602481930 @default.
- W2007691849 cites W1627446849 @default.
- W2007691849 cites W1678188980 @default.
- W2007691849 cites W1819107323 @default.
- W2007691849 cites W1821491276 @default.
- W2007691849 cites W1929828037 @default.
- W2007691849 cites W1946004772 @default.
- W2007691849 cites W1970053578 @default.
- W2007691849 cites W1972057413 @default.
- W2007691849 cites W1978002465 @default.
- W2007691849 cites W1979586675 @default.
- W2007691849 cites W1995357799 @default.
- W2007691849 cites W1998311031 @default.
- W2007691849 cites W2003729768 @default.
- W2007691849 cites W2006851823 @default.
- W2007691849 cites W2009423149 @default.
- W2007691849 cites W2018784755 @default.
- W2007691849 cites W2028160379 @default.
- W2007691849 cites W2031472414 @default.
- W2007691849 cites W2039959072 @default.
- W2007691849 cites W2046140532 @default.
- W2007691849 cites W2049871798 @default.
- W2007691849 cites W2051221009 @default.
- W2007691849 cites W2062989356 @default.
- W2007691849 cites W2065034289 @default.
- W2007691849 cites W2073008966 @default.
- W2007691849 cites W2079557858 @default.
- W2007691849 cites W2081831423 @default.
- W2007691849 cites W2087444289 @default.
- W2007691849 cites W2092376456 @default.
- W2007691849 cites W2101048381 @default.
- W2007691849 cites W2107406042 @default.
- W2007691849 cites W2109208582 @default.
- W2007691849 cites W2110691844 @default.
- W2007691849 cites W2114911095 @default.
- W2007691849 cites W2123067258 @default.
- W2007691849 cites W2127619125 @default.
- W2007691849 cites W2132971431 @default.
- W2007691849 cites W2164840188 @default.
- W2007691849 cites W2171784351 @default.
- W2007691849 cites W2194566372 @default.
- W2007691849 cites W2419136986 @default.
- W2007691849 cites W3021526609 @default.
- W2007691849 doi "https://doi.org/10.1016/s1044-7431(03)00238-0" @default.
- W2007691849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14664829" @default.
- W2007691849 hasPublicationYear "2003" @default.
- W2007691849 type Work @default.
- W2007691849 sameAs 2007691849 @default.
- W2007691849 citedByCount "35" @default.
- W2007691849 countsByYear W20076918492012 @default.
- W2007691849 countsByYear W20076918492013 @default.
- W2007691849 countsByYear W20076918492014 @default.
- W2007691849 countsByYear W20076918492016 @default.
- W2007691849 countsByYear W20076918492017 @default.
- W2007691849 countsByYear W20076918492019 @default.
- W2007691849 countsByYear W20076918492020 @default.
- W2007691849 crossrefType "journal-article" @default.
- W2007691849 hasAuthorship W2007691849A5018506745 @default.
- W2007691849 hasAuthorship W2007691849A5031754749 @default.
- W2007691849 hasAuthorship W2007691849A5043847188 @default.
- W2007691849 hasAuthorship W2007691849A5052365004 @default.
- W2007691849 hasConcept C160268369 @default.
- W2007691849 hasConcept C169760540 @default.
- W2007691849 hasConcept C170493617 @default.
- W2007691849 hasConcept C197341189 @default.
- W2007691849 hasConcept C55493867 @default.
- W2007691849 hasConcept C67018056 @default.
- W2007691849 hasConcept C73009533 @default.
- W2007691849 hasConcept C86803240 @default.
- W2007691849 hasConcept C95444343 @default.
- W2007691849 hasConcept C98229152 @default.
- W2007691849 hasConceptScore W2007691849C160268369 @default.
- W2007691849 hasConceptScore W2007691849C169760540 @default.
- W2007691849 hasConceptScore W2007691849C170493617 @default.
- W2007691849 hasConceptScore W2007691849C197341189 @default.
- W2007691849 hasConceptScore W2007691849C55493867 @default.
- W2007691849 hasConceptScore W2007691849C67018056 @default.
- W2007691849 hasConceptScore W2007691849C73009533 @default.
- W2007691849 hasConceptScore W2007691849C86803240 @default.
- W2007691849 hasConceptScore W2007691849C95444343 @default.
- W2007691849 hasConceptScore W2007691849C98229152 @default.
- W2007691849 hasFunder F4320321408 @default.
- W2007691849 hasFunder F4320322845 @default.
- W2007691849 hasIssue "3" @default.