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• W2007693488 abstract "•We describe cutting-edge single-cell epigenetics technologies. •We propose novel approaches to study dynamic epigenetic changes in individual cells. •We highlight microfluidics as a central tool for single-cell isolation and analysis. Mechanistically, how epigenetic states are inherited through cellular divisions remains an important open question in the chromatin field and beyond. Defining the heritability of epigenetic states and the underlying chromatin-based mechanisms within a population of cells is complicated due to cell heterogeneity combined with varying levels of stability of these states; thus, efforts must be focused toward single-cell analyses. The approaches presented here constitute the forefront of epigenetics research at the single-cell level using classic and innovative methods to dissect epigenetics mechanisms from the limited material available in a single cell. This review further outlines exciting future avenues of research to address the significance of epigenetic heterogeneity and the contributions of microfluidics technologies to single-cell isolation and analysis. Mechanistically, how epigenetic states are inherited through cellular divisions remains an important open question in the chromatin field and beyond. Defining the heritability of epigenetic states and the underlying chromatin-based mechanisms within a population of cells is complicated due to cell heterogeneity combined with varying levels of stability of these states; thus, efforts must be focused toward single-cell analyses. The approaches presented here constitute the forefront of epigenetics research at the single-cell level using classic and innovative methods to dissect epigenetics mechanisms from the limited material available in a single cell. This review further outlines exciting future avenues of research to address the significance of epigenetic heterogeneity and the contributions of microfluidics technologies to single-cell isolation and analysis." @default.
• W2007693488 created "2016-06-24" @default.
• W2007693488 creator A5002100865 @default.
• W2007693488 creator A5024044392 @default.
• W2007693488 date "2014-11-01" @default.
• W2007693488 modified "2023-09-25" @default.
• W2007693488 title "Epigenetics reloaded: the single-cell revolution" @default.
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• W2007693488 doi "https://doi.org/10.1016/j.tcb.2014.08.010" @default.
• W2007693488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25283892" @default.
• W2007693488 hasPublicationYear "2014" @default.
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