FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007697118> ?p ?o ?g. }

• W2007697118 endingPage "1484" @default.
• W2007697118 startingPage "1473" @default.
• W2007697118 abstract "PBCC211, an aroA aroD derivative of S. typhi strain CDC10-80, was tested in phase I trials as a single dose typhoid fever vaccine. Three different vaccine preparations, reconstituted lyophilized bacteria, freshly grown bacteria or lyophilized bacteria reconstituted from sachets, were orally administered to a total of 86 adult volunteers. An aroA aroD htrA strain, PBCC222, was also tested in 38 volunteers. Formulation impacted on the determination of a safe and immunogenic dose; reconstituted lyophilized cultures required higher doses than the broth cultures to stimulate seroconversion. In general, doses which seroconverted the majority of group members produced undesirable symptoms regardless of attenuation or formulation. The inability to separate the presence of symptoms from achieving significant immunogenicity in these aroA aroD or aroA aroD htrA strains precludes their use as single dose typhoid vaccines in the formulations tested. Multiple doses of these strains at a lower, safe level may be effective as vectors for foreign antigens." @default.
• W2007697118 created "2016-06-24" @default.
• W2007697118 creator A5008535155 @default.
• W2007697118 creator A5010103437 @default.
• W2007697118 creator A5016729430 @default.
• W2007697118 creator A5020680319 @default.
• W2007697118 creator A5029072015 @default.
• W2007697118 creator A5040313094 @default.
• W2007697118 creator A5050427349 @default.
• W2007697118 creator A5054698964 @default.
• W2007697118 creator A5072989432 @default.
• W2007697118 creator A5076497468 @default.
• W2007697118 creator A5082518551 @default.
• W2007697118 creator A5087861993 @default.
• W2007697118 creator A5088105178 @default.
• W2007697118 creator A5088976020 @default.
• W2007697118 date "2000-02-01" @default.
• W2007697118 modified "2023-10-01" @default.
• W2007697118 title "Phase I clinical trials of aroA aroD and aroA aroD htrA attenuated S. typhi vaccines; effect of formulation on safety and immunogenicity" @default.
• W2007697118 cites W1550583850 @default.
• W2007697118 cites W1706101476 @default.
• W2007697118 cites W1822798900 @default.
• W2007697118 cites W1964683475 @default.
• W2007697118 cites W1974202212 @default.
• W2007697118 cites W1985942985 @default.
• W2007697118 cites W2009009845 @default.
• W2007697118 cites W2010969919 @default.
• W2007697118 cites W2011683499 @default.
• W2007697118 cites W2023206510 @default.
• W2007697118 cites W2041505579 @default.
• W2007697118 cites W2042343008 @default.
• W2007697118 cites W2049191425 @default.
• W2007697118 cites W2051690171 @default.
• W2007697118 cites W2086302454 @default.
• W2007697118 cites W2094614302 @default.
• W2007697118 cites W2099000249 @default.
• W2007697118 cites W2104487243 @default.
• W2007697118 cites W2110176907 @default.
• W2007697118 cites W2119460480 @default.
• W2007697118 cites W2123269578 @default.
• W2007697118 cites W2323053493 @default.
• W2007697118 cites W51038676 @default.
• W2007697118 doi "https://doi.org/10.1016/s0264-410x(99)00424-7" @default.
• W2007697118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10618545" @default.
• W2007697118 hasPublicationYear "2000" @default.
• W2007697118 type Work @default.
• W2007697118 sameAs 2007697118 @default.
• W2007697118 citedByCount "48" @default.
• W2007697118 countsByYear W20076971182012 @default.
• W2007697118 countsByYear W20076971182013 @default.
• W2007697118 countsByYear W20076971182014 @default.
• W2007697118 countsByYear W20076971182015 @default.
• W2007697118 countsByYear W20076971182018 @default.
• W2007697118 countsByYear W20076971182019 @default.
• W2007697118 countsByYear W20076971182023 @default.
• W2007697118 crossrefType "journal-article" @default.
• W2007697118 hasAuthorship W2007697118A5008535155 @default.
• W2007697118 hasAuthorship W2007697118A5010103437 @default.
• W2007697118 hasAuthorship W2007697118A5016729430 @default.
• W2007697118 hasAuthorship W2007697118A5020680319 @default.
• W2007697118 hasAuthorship W2007697118A5029072015 @default.
• W2007697118 hasAuthorship W2007697118A5040313094 @default.
• W2007697118 hasAuthorship W2007697118A5050427349 @default.
• W2007697118 hasAuthorship W2007697118A5054698964 @default.
• W2007697118 hasAuthorship W2007697118A5072989432 @default.
• W2007697118 hasAuthorship W2007697118A5076497468 @default.
• W2007697118 hasAuthorship W2007697118A5082518551 @default.
• W2007697118 hasAuthorship W2007697118A5087861993 @default.
• W2007697118 hasAuthorship W2007697118A5088105178 @default.
• W2007697118 hasAuthorship W2007697118A5088976020 @default.
• W2007697118 hasConcept C104317684 @default.
• W2007697118 hasConcept C147483822 @default.
• W2007697118 hasConcept C159047783 @default.
• W2007697118 hasConcept C203014093 @default.
• W2007697118 hasConcept C2522874641 @default.
• W2007697118 hasConcept C2776714567 @default.
• W2007697118 hasConcept C2777451964 @default.
• W2007697118 hasConcept C2778663903 @default.
• W2007697118 hasConcept C2778910516 @default.
• W2007697118 hasConcept C2779574690 @default.
• W2007697118 hasConcept C2780868878 @default.
• W2007697118 hasConcept C501593827 @default.
• W2007697118 hasConcept C520601542 @default.
• W2007697118 hasConcept C523546767 @default.
• W2007697118 hasConcept C54355233 @default.
• W2007697118 hasConcept C547475151 @default.
• W2007697118 hasConcept C55493867 @default.
• W2007697118 hasConcept C71924100 @default.
• W2007697118 hasConcept C86803240 @default.
• W2007697118 hasConcept C89423630 @default.
• W2007697118 hasConceptScore W2007697118C104317684 @default.
• W2007697118 hasConceptScore W2007697118C147483822 @default.
• W2007697118 hasConceptScore W2007697118C159047783 @default.
• W2007697118 hasConceptScore W2007697118C203014093 @default.
• W2007697118 hasConceptScore W2007697118C2522874641 @default.
• W2007697118 hasConceptScore W2007697118C2776714567 @default.
• W2007697118 hasConceptScore W2007697118C2777451964 @default.
• W2007697118 hasConceptScore W2007697118C2778663903 @default.

• next