FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007700265> ?p ?o ?g. }

• W2007700265 endingPage "119a" @default.
• W2007700265 startingPage "119a" @default.
• W2007700265 abstract "Small conductance calcium-activated potassium (SK) channels are upregulated in ventricular myocytes from human patients and animal models of heart failure (HF). However, their activation mechanism and function in ventricular myocytes remain elusive. We overexpressed SK2 channels in adult rat ventricular myocytes using adenovirus gene transfer to test the hypotheses that activation of SK channels in ventricular myocytes requires calcium release from sarcoplasmic reticulum (SR), and that upregulation of SK currents contributes to reducing triggered activity. Simultaneous voltage clamp and confocal calcium imaging experiments in SK2-overexpressing cells demonstrated that depolarizing voltage steps resulted in transient outward currents sensitive to the specific SK channel inhibitor apamin. SR calcium release induced by rapid application of 10 mM caffeine evoked repolarizing SK currents, whereas complete exhaustion of SR calcium stores eliminated SK currents in response to depolarizing voltage steps, despite intact calcium influx through L-type calcium channels. Furthermore, apamin-sensitive SK currents were activated by pro-arrhythmic global spontaneous SR calcium release events (calcium waves, SCWs). Current-clamp experiments demonstrated that SK overexpression reduced the amplitude of delayed afterdepolarizations (DADs) resulting from SCWs and shortened action potential duration (APD). Immuno-localization studies revealed that overexpressed SK channels were distributed both at external sarcolemmal membranes and along the Z-lines, resembling the distribution of endogenous SK channels. In summary, SR calcium release is both necessary and sufficient for the activation of SK channels in rat ventricular myocytes. SK currents contribute to repolarization during action potentials and attenuate DADs driven by SCWs. Thus, SK upregulation in HF may have an anti-arrhythmic effect by shortening APD and reducing triggered activity." @default.
• W2007700265 created "2016-06-24" @default.
• W2007700265 creator A5009871577 @default.
• W2007700265 creator A5011616550 @default.
• W2007700265 creator A5011626611 @default.
• W2007700265 creator A5074613232 @default.
• W2007700265 creator A5075692221 @default.
• W2007700265 creator A5083671106 @default.
• W2007700265 date "2014-01-01" @default.
• W2007700265 modified "2023-09-27" @default.
• W2007700265 title "Activation of Small Conductance Calcium-Activated Potassium Channels by Sarcoplasmic Reticulum Calcium Release Attenuates Delayed Afterdepolarizations in Ventricular Myocytes" @default.
• W2007700265 doi "https://doi.org/10.1016/j.bpj.2013.11.715" @default.
• W2007700265 hasPublicationYear "2014" @default.
• W2007700265 type Work @default.
• W2007700265 sameAs 2007700265 @default.
• W2007700265 citedByCount "0" @default.
• W2007700265 crossrefType "journal-article" @default.
• W2007700265 hasAuthorship W2007700265A5009871577 @default.
• W2007700265 hasAuthorship W2007700265A5011616550 @default.
• W2007700265 hasAuthorship W2007700265A5011626611 @default.
• W2007700265 hasAuthorship W2007700265A5074613232 @default.
• W2007700265 hasAuthorship W2007700265A5075692221 @default.
• W2007700265 hasAuthorship W2007700265A5083671106 @default.
• W2007700265 hasBestOaLocation W20077002651 @default.
• W2007700265 hasConcept C12554922 @default.
• W2007700265 hasConcept C126322002 @default.
• W2007700265 hasConcept C134018914 @default.
• W2007700265 hasConcept C146403970 @default.
• W2007700265 hasConcept C147944092 @default.
• W2007700265 hasConcept C149614440 @default.
• W2007700265 hasConcept C149786707 @default.
• W2007700265 hasConcept C155730078 @default.
• W2007700265 hasConcept C170493617 @default.
• W2007700265 hasConcept C178790620 @default.
• W2007700265 hasConcept C185263204 @default.
• W2007700265 hasConcept C185592680 @default.
• W2007700265 hasConcept C18699975 @default.
• W2007700265 hasConcept C207200792 @default.
• W2007700265 hasConcept C2776919887 @default.
• W2007700265 hasConcept C30979828 @default.
• W2007700265 hasConcept C4141045 @default.
• W2007700265 hasConcept C50254741 @default.
• W2007700265 hasConcept C519063684 @default.
• W2007700265 hasConcept C55493867 @default.
• W2007700265 hasConcept C71924100 @default.
• W2007700265 hasConcept C83743174 @default.
• W2007700265 hasConcept C86803240 @default.
• W2007700265 hasConceptScore W2007700265C12554922 @default.
• W2007700265 hasConceptScore W2007700265C126322002 @default.
• W2007700265 hasConceptScore W2007700265C134018914 @default.
• W2007700265 hasConceptScore W2007700265C146403970 @default.
• W2007700265 hasConceptScore W2007700265C147944092 @default.
• W2007700265 hasConceptScore W2007700265C149614440 @default.
• W2007700265 hasConceptScore W2007700265C149786707 @default.
• W2007700265 hasConceptScore W2007700265C155730078 @default.
• W2007700265 hasConceptScore W2007700265C170493617 @default.
• W2007700265 hasConceptScore W2007700265C178790620 @default.
• W2007700265 hasConceptScore W2007700265C185263204 @default.
• W2007700265 hasConceptScore W2007700265C185592680 @default.
• W2007700265 hasConceptScore W2007700265C18699975 @default.
• W2007700265 hasConceptScore W2007700265C207200792 @default.
• W2007700265 hasConceptScore W2007700265C2776919887 @default.
• W2007700265 hasConceptScore W2007700265C30979828 @default.
• W2007700265 hasConceptScore W2007700265C4141045 @default.
• W2007700265 hasConceptScore W2007700265C50254741 @default.
• W2007700265 hasConceptScore W2007700265C519063684 @default.
• W2007700265 hasConceptScore W2007700265C55493867 @default.
• W2007700265 hasConceptScore W2007700265C71924100 @default.
• W2007700265 hasConceptScore W2007700265C83743174 @default.
• W2007700265 hasConceptScore W2007700265C86803240 @default.
• W2007700265 hasIssue "2" @default.
• W2007700265 hasLocation W20077002651 @default.
• W2007700265 hasOpenAccess W2007700265 @default.
• W2007700265 hasPrimaryLocation W20077002651 @default.
• W2007700265 hasRelatedWork W1845756101 @default.
• W2007700265 hasRelatedWork W1855846814 @default.
• W2007700265 hasRelatedWork W1976296201 @default.
• W2007700265 hasRelatedWork W1978554794 @default.
• W2007700265 hasRelatedWork W2029620282 @default.
• W2007700265 hasRelatedWork W2074274080 @default.
• W2007700265 hasRelatedWork W2079698443 @default.
• W2007700265 hasRelatedWork W2079788818 @default.
• W2007700265 hasRelatedWork W2090702022 @default.
• W2007700265 hasRelatedWork W2093680892 @default.
• W2007700265 hasRelatedWork W2124236528 @default.
• W2007700265 hasRelatedWork W2148750197 @default.
• W2007700265 hasRelatedWork W2301435893 @default.
• W2007700265 hasRelatedWork W2334337166 @default.
• W2007700265 hasRelatedWork W2338264348 @default.
• W2007700265 hasRelatedWork W2585793758 @default.
• W2007700265 hasRelatedWork W2625653080 @default.
• W2007700265 hasRelatedWork W2885720536 @default.
• W2007700265 hasRelatedWork W2914762618 @default.
• W2007700265 hasRelatedWork W2998709048 @default.
• W2007700265 hasVolume "106" @default.
• W2007700265 isParatext "false" @default.
• W2007700265 isRetracted "false" @default.
• W2007700265 magId "2007700265" @default.

• next