FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007706148> ?p ?o ?g. }

• W2007706148 endingPage "28" @default.
• W2007706148 startingPage "21" @default.
• W2007706148 abstract "Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that promotes tumorigenesis by epigenetic repression of tumor suppressor genes. Although EZH2 is overexpressed in many malignancies, activating EZH2 mutations have been described predominantly in follicular lymphoma and diffuse large B-cell lymphoma. EZH2 activating mutations in melanoma are not well described. Here, we report a case of cutaneous melanoma that displayed an EZH2 (Y641S) activating mutation detected by transcriptome sequencing as well as BRAF (V600K). The patient had concurrent follicular lymphoma that lacked both the EZH2 (Y641) and BRAF (V600K) mutations present in the patient's melanoma. Further, we screened publicly available sequence data and identified four additional melanoma cases harboring activating EZH2 mutation. Our findings provide additional evidence that activating recurrent EZH2 mutations occur in cutaneous melanoma, to our knowledge the first solid tumor shown to" @default.
• W2007706148 created "2016-06-24" @default.
• W2007706148 creator A5003311852 @default.
• W2007706148 creator A5016216331 @default.
• W2007706148 creator A5035266638 @default.
• W2007706148 creator A5042167871 @default.
• W2007706148 creator A5050235042 @default.
• W2007706148 creator A5051133829 @default.
• W2007706148 creator A5053360118 @default.
• W2007706148 creator A5054784668 @default.
• W2007706148 creator A5058395887 @default.
• W2007706148 creator A5060849370 @default.
• W2007706148 creator A5064487000 @default.
• W2007706148 creator A5083968353 @default.
• W2007706148 date "2014-06-01" @default.
• W2007706148 modified "2023-10-16" @default.
• W2007706148 title "Activating mutations of the oncogene EZH2 in cutaneous melanoma revealed by next generation sequencing" @default.
• W2007706148 cites W1856564249 @default.
• W2007706148 cites W1900973458 @default.
• W2007706148 cites W1973628185 @default.
• W2007706148 cites W1994158976 @default.
• W2007706148 cites W1996487270 @default.
• W2007706148 cites W2004380688 @default.
• W2007706148 cites W2009096660 @default.
• W2007706148 cites W2018308631 @default.
• W2007706148 cites W2019564564 @default.
• W2007706148 cites W2024373518 @default.
• W2007706148 cites W2026196315 @default.
• W2007706148 cites W2035000040 @default.
• W2007706148 cites W2057065967 @default.
• W2007706148 cites W2061587893 @default.
• W2007706148 cites W2061846271 @default.
• W2007706148 cites W2064469303 @default.
• W2007706148 cites W2085864013 @default.
• W2007706148 cites W2100365251 @default.
• W2007706148 cites W2103557568 @default.
• W2007706148 cites W2110567963 @default.
• W2007706148 cites W2125496315 @default.
• W2007706148 cites W2131040858 @default.
• W2007706148 cites W2133040382 @default.
• W2007706148 cites W2134471382 @default.
• W2007706148 cites W2148217229 @default.
• W2007706148 cites W2149793889 @default.
• W2007706148 cites W2150677022 @default.
• W2007706148 cites W2169810552 @default.
• W2007706148 cites W2327772647 @default.
• W2007706148 doi "https://doi.org/10.1016/j.ehpc.2014.07.002" @default.
• W2007706148 hasPublicationYear "2014" @default.
• W2007706148 type Work @default.
• W2007706148 sameAs 2007706148 @default.
• W2007706148 citedByCount "8" @default.
• W2007706148 countsByYear W20077061482016 @default.
• W2007706148 countsByYear W20077061482017 @default.
• W2007706148 countsByYear W20077061482019 @default.
• W2007706148 countsByYear W20077061482020 @default.
• W2007706148 countsByYear W20077061482022 @default.
• W2007706148 crossrefType "journal-article" @default.
• W2007706148 hasAuthorship W2007706148A5003311852 @default.
• W2007706148 hasAuthorship W2007706148A5016216331 @default.
• W2007706148 hasAuthorship W2007706148A5035266638 @default.
• W2007706148 hasAuthorship W2007706148A5042167871 @default.
• W2007706148 hasAuthorship W2007706148A5050235042 @default.
• W2007706148 hasAuthorship W2007706148A5051133829 @default.
• W2007706148 hasAuthorship W2007706148A5053360118 @default.
• W2007706148 hasAuthorship W2007706148A5054784668 @default.
• W2007706148 hasAuthorship W2007706148A5058395887 @default.
• W2007706148 hasAuthorship W2007706148A5060849370 @default.
• W2007706148 hasAuthorship W2007706148A5064487000 @default.
• W2007706148 hasAuthorship W2007706148A5083968353 @default.
• W2007706148 hasBestOaLocation W20077061481 @default.
• W2007706148 hasConcept C104317684 @default.
• W2007706148 hasConcept C2777658100 @default.
• W2007706148 hasConcept C2781018059 @default.
• W2007706148 hasConcept C29537977 @default.
• W2007706148 hasConcept C41091548 @default.
• W2007706148 hasConcept C50171091 @default.
• W2007706148 hasConcept C502942594 @default.
• W2007706148 hasConcept C51679486 @default.
• W2007706148 hasConcept C54355233 @default.
• W2007706148 hasConcept C86803240 @default.
• W2007706148 hasConceptScore W2007706148C104317684 @default.
• W2007706148 hasConceptScore W2007706148C2777658100 @default.
• W2007706148 hasConceptScore W2007706148C2781018059 @default.
• W2007706148 hasConceptScore W2007706148C29537977 @default.
• W2007706148 hasConceptScore W2007706148C41091548 @default.
• W2007706148 hasConceptScore W2007706148C50171091 @default.
• W2007706148 hasConceptScore W2007706148C502942594 @default.
• W2007706148 hasConceptScore W2007706148C51679486 @default.
• W2007706148 hasConceptScore W2007706148C54355233 @default.
• W2007706148 hasConceptScore W2007706148C86803240 @default.
• W2007706148 hasIssue "2" @default.
• W2007706148 hasLocation W20077061481 @default.
• W2007706148 hasOpenAccess W2007706148 @default.
• W2007706148 hasPrimaryLocation W20077061481 @default.
• W2007706148 hasRelatedWork W1969485334 @default.
• W2007706148 hasRelatedWork W2517922855 @default.
• W2007706148 hasRelatedWork W2613842309 @default.
• W2007706148 hasRelatedWork W2652273880 @default.

• next