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• W2007715507 abstract "The loading and relase of ibuprofen, Ketoprofen and mefenamic acid from a range of strong anionic exchange resins, including cholestyramine, is decribed. Release rates into simulated gastric fluid increase with stirring speed up to 300 rpm and decrease as either the particle size of the resin beads of the degree of cross-linking increase. An increase in the temperature of loading enhances the capacity of the resin towards the drug and reduce its relase rate. Coating of the resing also enables suppression of drug release to be achieved. The samll particle size of cholestyramine enables a rapid relese of drug from the resin to be achieved. This rate is significantly greater than that obtained by monitoring dissolution from a drug-lactose dispersion and may indicate that ion-exchange technology may provide and opportunity to overcome poor dissolution characteristicsf for weekly ionic compounds." @default.
• W2007715507 created "2016-06-24" @default.
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• W2007715507 date "1990-01-01" @default.
• W2007715507 modified "2023-09-26" @default.
• W2007715507 title "Drug-Delivery By Ion-Exchnage. Part VII: Release of Acidic Drugs from Anionic Exchange Resinate Complexes" @default.
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• W2007715507 doi "https://doi.org/10.3109/03639049009114916" @default.
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